CLINICAL MANIFESTATION OF A CAT WITH ACUTE ACETAMINOPHEN TOXICITY

Year 2024, Volume: 3 Issue: 2, 39 - 46, 31.12.2024

Esma Kısmet , Halid Recep , Fatma Akdağ , Erdem Gülersoy

https://doi.org/10.61262/vetjku.1566128

Abstract

This case report presents diagnostic methods used for a 2.5 kg, 1-year-old female British Shorthair cat admitted to a veterinary hospital with non-specific symptoms, including anorexia, lethargy, jaundice, and dehydration. After a comprehensive evaluation of the anamnesis, clinical findings, laboratory results, imaging, and the exclusion of similar diseases, a diagnosis of iatrogenic acetaminophen toxicity was established. While numerous case reports and studies address acetaminophen toxicity, this report emphasizes how the employed diagnostic methods contribute to accurate diagnosis. Ultimately, thorough evaluation of anamnesis data, combined with these examination techniques, can facilitate precise disease identification and enhance awareness of its characteristics. Moreover, case reports like this one can increase awareness and help reduce fatalities associated with acetaminophen intoxication.

Keywords

Acetaminophen, Cat, Toxicity

Ethical Statement

This study does not present any ethical concerns.

Supporting Institution

This study did not receive a support by any financial institution/sector.

Thanks

The authors would like to thank their faculties.

References

• Allen, A. L. (2003). The diagnosis of acetaminophen toxicosis in a cat. The Canadian Veterinary Journal, 44(6), 509-510.
• Aronson, L. R., & Drobatz, K. (1996). Acetaminophen toxicosis in 17 cats. Journal of Veterinary Emergency and Critical Care, 6(2), 65-69. https://doi.org/10.1111/j.14764431.1996.tb00034.x
• Bates, N. (2013). Paracetamol poisoning in cats. Veterinary Medicine, 263-267.
• Denzoin Vulcano, L. A., Confalonieri, O., Franci, R., Tapia, M. O., & Soraci, A.L. (2013). Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminopheninduced hepatotoxicity in cats. Open Veterinary Journal, 3(1), 56-63.
• El Brihi, J., & Pathak, S. (2024). Normal and Abnormal Complete Blood Count With Differential. In StatPearls. StatPearls Publishing.
• Ettinger, S. J. & Feldman, E. C. (2010). Textbook of veterinary internal medicine vol 2. Philadelphia, US: W.B. Saunders.
• Gülersoy, E., Balıkçı, C., & Sevinç, M. (2021). Veteriner Hekimlikte OTC İlaçlar. Harran Üniversitesi Veteriner Fakültesi Dergisi, 10(2), 203-210. https://doi.org/10.31196/huvfd.907363
• Juma, K. K., Joseph, N. J. N., David, M. N. (2015). A Review of the Biochemical, Hematological and Histological Modulations in Acetaminophen Induced Hepatoxicity and the Potential of Urtica Dioica in the Regeneration of the Liver. Journal of Drug Metabolism & Toxicology, 6(3), 1-7. https://doi.org/10.4172/2157-7609.1000182
• Klaassen, J. K. (1999). Reference values in veterinary medicine. Laboratory medicine, 30(3), 194-197. https://doi.org/10.1093/labmed/30.3.194
• Özkan, B. (2017). Acetaminophen toxicosis in a cat. Journal of Istanbul Veterinary Sciences, 1(1), 1-4. http://dx.doi.org/10.30704/http-www-jivs-net.295062
• Richardson, J. A. (2000). Management of acetaminophen and ibufrofen toxicoses in dogs and cats. Journal of Veterinary Emergency and Critical Care, 10(4), 285-291.https://doi.org/10.1111/j.1476-4431.2000.tb00013.x
• Sidhu, S., Randhir, S., & Neetu, S. (2021). Acetaminophen toxicity in a cat and its treatment. Indian Journal of Veterinary Medicine, 41(1), 75-77.
• Singh, A., Bhat, T. K., & Sharma, O. P. (2011). Clinical biochemistry of hepatotoxicity. J Clinic Toxicol S, 4, 2161-0495. http://dx.doi.org/10.4172/2161-0495.S4-001
• Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019). Hypoalbuminemia: Pathogenesis and Clinical Significance. JPEN. Journal of parenteral and enteral nutrition, 43(2), 181–193. https://doi.org/10.1002/jpen.1451
• Suciu, M., Gruia, A. T., Nica, D. V., Azghadi, S. M., Mic, A. A., & Mic, F. A. (2015). Acetaminophen-induced liver injury: Implications for temporal homeostasis of lipid metabolism and eicosanoid signaling pathway. Chemico-biological interactions, 242, 335–344. https://doi.org/10.1016/j.cbi.2015.10.019
• Tanaka H. (2020). Current role of ultrasound in the diagnosis of hepatocellular carcinoma. Journal of medical ultrasonics, 47(2), 239–255. https://doi.org/10.1007/s10396-020-01012-y