Descriptive analysis of the burden of Mpox in Nigeria 2022-2024

Year 2025, Volume: 4 Issue: 1, 5 - 13, 30.06.2025

Okoli Chieloka , Abdulkereem Durosinlorun Ogugua Akwoba Joseph

https://doi.org/10.61262/vetjku.1652110

Abstract

Aim to study: Nigeria has continued reporting outbreaks of Mpox since 2017 despite control measures instituted by the one health tripartite sector. This study aimed to assess the burden of Mpox in Nigeria between 2022 and 2024 by identifying geographical hotspots and calculating epidemic thresholds based on reported cases.
Material and methods: Mpox outbreak reports from the Nigeria Centre for Disease Control and Prevention (NCDC) for 2022–2024 were reviewed to identify affected states and determine confirmed case counts. Geospatial analysis was conducted using ArcGIS software to identify Mpox outbreak hotspots.
Results: A total of 984 confirmed Mpox cases were reported across 36 states and the Federal Capital Territory (FCT), resulting in 9 fatalities. Lagos State emerged as a major hotspot, accounting for 24.7% of cases (188 cases) in 2022, while Cross River and Plateau States became prominent in 2024. The epidemic thresholds were 115 in 2022, 43 in 2023, and 15 in 2024. Young adults aged 21-40 years were the most affected, and children under 10 years represented an emerging at-risk group in 2024, comprising 30% of reported cases. Geospatial analysis revealed shifting hotspots, contrary to earlier studies that identified Rivers and Bayelsa as major clusters.
Conclusion: These findings underscore the need for enhanced surveillance, targeted public health interventions, and improved healthcare access to mitigate Mpox transmission in Nigeria.

Keywords

Epidemic threshold , Arc Geographical information system , MPOX

Ethical Statement

The project was approved by the ethics committee of the College of Veterinary Surgeons(5.04.2025.CVSN/VPMF/23/22)

Supporting Institution

Collage of Veterinary surgeon of Nigeria

Thanks

5/3/2025

References

• Abafi, D. S. O., Adewunmi, M. O., Michael, O. O., Kia, G. S. N., Adeyemo, O. K., Alarape, S. A., Meseko, C. A., Oyetunde, J. S., Mkpuma, N., Shorunke, F. O., & Aiki-Raji, C. O. (2024). Molecular detection of monkeypox virus in wild rodents and humans in Ibadan, Nigeria—A cross-sectional study. PAMJ - One Health, 13. https://doi.org/10.11604/pamj- oh.2024.13.16.42143
• Beer, E. M., & Rao, V. B. (2019). A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. PLOS Neglected Tropical Diseases, 13(10), e0007791. https://doi.org/10.1371/journal.pntd.0007791
• Center for Disease Control. (2024). Mpox in Animals and Pets. https://www.cdc.gov/poxvirus/mpox/veterinarian/ mpox-in- animals.html#:~:text=Monkeypox%20virus%20c an%20infect%20a,to%20animals%20through%20 close%20contact.
• Chieloka, O. S., Amao, L. K., Akinrogbe, J. T., Iniobong, J.-I., & Burga, J. (2020). Outbreak Investigation of Monkeypox in Akwa Ibom State: A Matched Case Control Study 14th - 24th October 2019. East African Journal of Health and Science, 1(1), 37– 44. https://doi.org/10.37284/eajhs.1.1.57
• Chieloka, O. S., Bammani, I. M., & Amao, L. K. (2022a). Descriptive epidemiology of the burden of human monkeypox in Nigeria: A retrospective review 2017-2021. PAMJ - One Health, 8. https://doi.org/10.11604/pamj- oh.2022.8.12.36024
• Durski, K. N., McCollum, A. M., Nakazawa, Y., Petersen, B. W., Reynolds, M. G., Briand, S., Djingarey, M. H., Olson, V., Damon, I. K., & Khalakdina, A. (2018). Emergence of Monkeypox—West and Central Africa, 1970–2017. MMWR. Morbidity and Mortality Weekly Report, 67(10), 306–310. https://doi.org/10.15585/mmwr.mm6710a5
• Heymann, D. L., Szczeniowski, M., & Esteves, K. (1998). Re-emergence of monkeypox in Africa: A review of the past six years. British Medical Bulletin, 54(3), 693–702. https://doi.org/10.1093/oxfordjournals.bmb.a0117 20
• Kaler, J., Hussain, A., Flores, G., Kheiri, S., & Desrosiers, D. (2022). Monkeypox: A Comprehensive Review of Transmission, Pathogenesis, and Manifestation. Cureus. https://doi.org/10.7759/cureus.26531
• Mauldin, M. R., McCollum, A. M., Nakazawa, Y. J., Mandra, A., Whitehouse, E. R., Davidson, W., Zhao, H., Gao, J., Li, Y., Doty, J., Yinka- Ogunleye, A., Akinpelu, A., Aruna, O., Naidoo, D., Lewandowski, K., Afrough, B., Graham, V., Aarons, E., Hewson, R., … Reynolds, M. G. (2022). Exportation of Monkeypox Virus From the African Continent. The Journal of Infectious Diseases, 225(8), 1367–1376. https://doi.org/10.1093/infdis/jiaa559
• Nolen, L. D., Osadebe, L., Katomba, J., Likofata, J., Mukadi, D., Monroe, B., Doty, J., Hughes, C. M., Kabamba, J., Malekani, J., Bomponda, P. L., Lokota, J. I., Balilo, M. P., Likafi, T., Lushima, R. S., Ilunga, B. K., Nkawa, F., Pukuta, E., Karhemere, S., … Reynolds, M. G. (2016). Extended Human-to-Human Transmission during a Monkeypox Outbreak in the Democratic Republic of the Congo. Emerging Infectious Diseases, 22(6), 1014–1021. https://doi.org/10.3201/eid2206.150579
• Owoicho, S. (2019, April 10). Socio-demographic and exposure factors associated with confirmed cases of monkeypox infection in Bayelsa State, Nigeria, 2017. 3rd International Conference on Influenza Research and Emerging Infectious Diseases. https://www.longdom.org/proceedings/sociodemo graphic-and-exposure-factors-associated-with-confirmed-cases-of-monkeypox-infection-in- bayelsa-state-nigeria-2017-58519.html
• Sejvar, J. J., Chowdary, Y., Schomogyi, M., Stevens, J., Patel, J., Karem, K., Fischer, M., Kuehnert, M. J., Zaki, S. R., Paddock, C. D., Guarner, J., Shieh, W., Patton, J. L., Bernard, N., Li, Y., Olson, V. A., Kline, R. L., Loparev, V. N., Schmid, D. S., … Damon, I. K. (2004). Human Monkeypox Infection: A Family Cluster in the Midwestern United States. The Journal of Infectious Diseases, 190(10), 1833–1840. https://doi.org/10.1086/425039
• The Guardian uk. (2022.). Monkeypox outbreak was waiting to happen, say scientists. Retrieved May 10, 2024, from https://www.theguardian.com/world/2022/may/24 /monkeypox-outbreak-was-waiting-to-happen- say-scientists
• Vaughan, A., Aarons, E., Astbury, J., Balasegaram, S., Beadsworth, M., Beck, C. R., Chand, M., O’Connor, C., Dunning, J., Ghebrehewet, S., Harper, N., Howlett-Shipley, R., Ihekweazu, C., Jacobs, M., Kaindama, L., Katwa, P., Khoo, S., Lamb, L., Mawdsley, S., Wilburn, J. (2018). Two cases of monkeypox imported to the United Kingdom, September 2018. Eurosurveillance, 23(38). https://doi.org/10.2807/1560- 7917.ES.2018.23.38.1800509
• Weinstein, R. A., Nalca, A., Rimoin, A. W., Bavari, S., & Whitehouse, C. A. (2005). Reemergence of Monkeypox: Prevalence, Diagnostics, and Countermeasures. Clinical Infectious Diseases, 41(12), 1765–1771. https://doi.org/10.1086/498155
• World Organization for Animal Health. (2024). Mpox:Is there a vaccine against mpox? Retrieved May 10, 2024, from https://www.who.int/news- room/questions-and-answers/item/monkeypox
• World Organisation for Animal Health, (2024a). Mpox (monkeypox). https://www.who.int/news- room/fact-sheets/detail/monkeypox
• World Organisation for Animal Health, (2024b). Mpox:Are gay, bisexual, or other men who have sex with men at higher risk of contracting mpox? https://www.who.int/news-room/questions-and- answers/item/monkeypox
• Worldometers. (2024). Nigeria Population. Retrieved May 15, 2024, from https://www.worldometers.info/world- population/nigeria-population/
• Yale Medicine. (2025). Mpox (Formerly Monkeypox): What are the symptoms of mpox? Retrieved May 10, 2024, from https://www.yalemedicine.org/conditions/monkey pox-mpox