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Sarcoptes canis’le Doğal Enfeste Köpeklerde Serum Neopterin ve Prokalsitonin Seviyeleri

Year 2023, Volume: 18 Issue: 1, 31 - 34, 26.04.2023

Abstract

Bu çalışmada Sarcoptes canis’le doğal enfeste köpeklerde serum neopterin ve prokalsitonin seviyelerinin belirlenmesi amaçlanmıştır. Çalışmanın hayvan materyalini farklı yaş ve cinsiyette 15
Sarcoptes canis’li ve sağlıklı 10 köpek oluşturdu. Hem Sarcoptes canis’li hemde sağlıklı köpeklerden bir kez kan alınarak 3000 devirde 10 dakika santrifüj edilerek serumları ayrıştırıldı. Elde edilen serumlar ölçümler yapılana kadar −20 ºC’de muhafaza edildi. Yapılan ölçümler sonucunda hasta köpeklerin neopterin (5,48 nmol/L ± 0,37 nmol/L) ve prokalsitonin (59,71 ng/L ± 2,45 ng/L)
değerleri sağlıklı köpeklerin neopterin (4,27 nmol/L ± 0,30 nmol/L) ve prokalsitonin (47,63 ng/L ±3,16 ng/L) değerlerine göre anlamlı derecede P < ,05 yüksek bulundu. Sonuç olarak Sarcoptes
canis’li köpeklerde deride şiddetli bir yangı gelişmektedir. Deride şekillenen bu yangı sonucu ortaya çıkan hücresel immun yanıt ve akut faz yanıtın belirleyicisi olarak neopterin ve prokalsitonin
biyobelirteçlerinin yükseldiği tespit edilmiştir.

References

  • 1. Meletis G, Oustas E, Kemanetzi C, Botziori C. Is the simple saline mount technique more effective than potassium hydroxide for the microscopic detection of Sarcoptes scabiei? J Parasitol. 2018;104(1):109-109. [CrossRef]
  • 2. Yipel Altınok F. Kedilerde Kulak Uyuzu (Otodectes Cynotis) Sağaltımında Ozonlanmış Zeytinyağı ve Bazı Esansiyel Yağların (allium sativum l, Origanum majorana l.) [Etkileri. Doktora Tezi]. Afyon; 2014.
  • 3. Curtis CF. Current trends in the treatment of Sarcoptes, cheylitiella and otodectes mite infestations in dogs and cats. Vet Dermatol. 2004;15(2):108-114. [CrossRef]
  • 4. Arslan A, Kırmızıgül A. Serum amyloid-a, haptoglobin and ceruloplasmin levels in dogs ınfected with Sarcoptes canis. Atatürk Üniv Vet Bilim Derg. 2020;15(1):1-6.
  • 5. Değer TB. Köpeklerde Sarkoptik Uyuzun Sağaltımında Topikal Eprinomektin Ile Permetrinin Etkinliklerinin Karşılaştırılması [Yüksek Lisans Tezi]. Aydın; 2012.
  • 6. Baydar T, Palabıyık S, Neopterin ŞG. Günümüzün popüler biyogöstergesi mi? Turk Klin J Med Sci. 2009;29(5):1280-1291.
  • 7. Berdowska A, Zwirska-Korczala K. Neopterin measurement in clinical diagnosis. J Clin Pharm Ther. 2001;26(5):319-329. [CrossRef]
  • 8. Cesur S, Aslan T, Hoca NT, et al. Clinical importance of serum neopterin level in patients with pulmonary tuberculosis. Int J Mycobacteriol. 2014;3(1):5-8. [CrossRef]
  • 9. Basbug O, Aydogdu U, Agaoglu ZT. Neopterin and soluble urokinase type plasminogen activator receptor as biomarkers in dogs with systemic ınflammatory response syndrome. J Hellenic Vet Med Soc. 2020;71(1). [CrossRef]
  • 10. Akyüz E, Gökce GG. Neopterin, procalcitonin, clinical biochemistry, and hematology in calves with neonatal sepsis. Trop Anim Health Prod. 2021;53(3):354. [CrossRef]
  • 11. Akyüz E, Merhan O, Aydın U, et al. Neopterin, procalcitonin, total sialic acid, paraoxonase-1 and selected haematological indices in calves with aspiration pneumonia. Acta Vet Brno. 2022;91(2):115-124. [CrossRef]
  • 12. Yıldırım Y, Gunel N, Coskun U, Pasaoglu H, Aslan S, Cetin A. Serum neopterin levels in patients with breast cancer. Med Oncol. 2008;25(4):403-407. [CrossRef]
  • 13. Tascene N, Kısmalı G, Vural S, Karagul H, Sel T. Serum neopterin, sialic acid and nitric oxide levels in dogs with malignant mammary tumours. Vet Comp Oncol. 2012;10(2):155-159. [CrossRef]
  • 14. Becker KL, Snider R, Nylen ES. Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit Care Med. 2008;36(3):941-952. [CrossRef]
  • 15. Matur E, Dokuzeylül B, Mukaddes Ö, et al. Can procalcitonin be used as a clinical biomarker during bacterial, viral and parasitic infections in dogs? Jpn J Vet Res. 2021;69(1):5-17.
  • 16. Christ-Crain M, Müller B. Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators. Eur Respir J. 2007;30(3):556-573. [CrossRef]
  • 17. Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13(5):426-435. [CrossRef]
  • 18. Troia R, Giunti M, Goggs R. Plasma procalcitonin concentrations predict organ dysfunction and outcome in dogs with sepsis. BMC Vet Res. 2018;14(1):111. [CrossRef]
  • 19. Brkljacic M, Brkljacic I, Torti M, et al. The concentrations of the inflammatory markers the amino-terminal portion of C-type pronatriuretic peptide and procalcitonin in canine babesiosis caused by Babesia canis. Vet Arh. 2014;84:575-589.
  • 20. Sharma S, Pokharel. Diagnosis and Therapeutic Management of Mixed Demodex and Sarcoptes Mite Infestation in Dog. ASAG2019;3:6.

Serum Neopterin and Procalcitonin Levels in Dogs Naturally Infested with Sarcoptes canis

Year 2023, Volume: 18 Issue: 1, 31 - 34, 26.04.2023

Abstract

This study aimed to determine serum neopterin and procalcitonin levels in dogs naturally infested with Sarcoptes canis. The animal material of the study consisted of 15 dogs with S. canis and 10
healthy dogs of different ages and genders. Blood was taken once from both S. canis infested dogs and healthy dogs, and their serums were separated by centrifugation at 3000 rpm for 10 minutes.
The obtained sera were stored at −20 ºC until the analyses. As a result of the analyses, neopterin (5,48 nmol/L ± 0,37 nmol/L) and procalcitonin (59,71 ng/L ± 2,45 ng/L) levels of the sick dogs were
found to be significantly higher (P < ,05) than the neopterin (4,27 nmol/L ± 0,30 nmol/L) and procalcitonin (47,63 ng/L ± 3,16 ng/L) levels of the healthy dogs. As a result, dogs with S. canis develop a severe skin inflammation. It has been determined that neopterin and procalcitonin biomarkers increased as the cells that emerged as a result of this fire formed in the skin, as the speech of the
immune response and acute phase response.

References

  • 1. Meletis G, Oustas E, Kemanetzi C, Botziori C. Is the simple saline mount technique more effective than potassium hydroxide for the microscopic detection of Sarcoptes scabiei? J Parasitol. 2018;104(1):109-109. [CrossRef]
  • 2. Yipel Altınok F. Kedilerde Kulak Uyuzu (Otodectes Cynotis) Sağaltımında Ozonlanmış Zeytinyağı ve Bazı Esansiyel Yağların (allium sativum l, Origanum majorana l.) [Etkileri. Doktora Tezi]. Afyon; 2014.
  • 3. Curtis CF. Current trends in the treatment of Sarcoptes, cheylitiella and otodectes mite infestations in dogs and cats. Vet Dermatol. 2004;15(2):108-114. [CrossRef]
  • 4. Arslan A, Kırmızıgül A. Serum amyloid-a, haptoglobin and ceruloplasmin levels in dogs ınfected with Sarcoptes canis. Atatürk Üniv Vet Bilim Derg. 2020;15(1):1-6.
  • 5. Değer TB. Köpeklerde Sarkoptik Uyuzun Sağaltımında Topikal Eprinomektin Ile Permetrinin Etkinliklerinin Karşılaştırılması [Yüksek Lisans Tezi]. Aydın; 2012.
  • 6. Baydar T, Palabıyık S, Neopterin ŞG. Günümüzün popüler biyogöstergesi mi? Turk Klin J Med Sci. 2009;29(5):1280-1291.
  • 7. Berdowska A, Zwirska-Korczala K. Neopterin measurement in clinical diagnosis. J Clin Pharm Ther. 2001;26(5):319-329. [CrossRef]
  • 8. Cesur S, Aslan T, Hoca NT, et al. Clinical importance of serum neopterin level in patients with pulmonary tuberculosis. Int J Mycobacteriol. 2014;3(1):5-8. [CrossRef]
  • 9. Basbug O, Aydogdu U, Agaoglu ZT. Neopterin and soluble urokinase type plasminogen activator receptor as biomarkers in dogs with systemic ınflammatory response syndrome. J Hellenic Vet Med Soc. 2020;71(1). [CrossRef]
  • 10. Akyüz E, Gökce GG. Neopterin, procalcitonin, clinical biochemistry, and hematology in calves with neonatal sepsis. Trop Anim Health Prod. 2021;53(3):354. [CrossRef]
  • 11. Akyüz E, Merhan O, Aydın U, et al. Neopterin, procalcitonin, total sialic acid, paraoxonase-1 and selected haematological indices in calves with aspiration pneumonia. Acta Vet Brno. 2022;91(2):115-124. [CrossRef]
  • 12. Yıldırım Y, Gunel N, Coskun U, Pasaoglu H, Aslan S, Cetin A. Serum neopterin levels in patients with breast cancer. Med Oncol. 2008;25(4):403-407. [CrossRef]
  • 13. Tascene N, Kısmalı G, Vural S, Karagul H, Sel T. Serum neopterin, sialic acid and nitric oxide levels in dogs with malignant mammary tumours. Vet Comp Oncol. 2012;10(2):155-159. [CrossRef]
  • 14. Becker KL, Snider R, Nylen ES. Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit Care Med. 2008;36(3):941-952. [CrossRef]
  • 15. Matur E, Dokuzeylül B, Mukaddes Ö, et al. Can procalcitonin be used as a clinical biomarker during bacterial, viral and parasitic infections in dogs? Jpn J Vet Res. 2021;69(1):5-17.
  • 16. Christ-Crain M, Müller B. Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators. Eur Respir J. 2007;30(3):556-573. [CrossRef]
  • 17. Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13(5):426-435. [CrossRef]
  • 18. Troia R, Giunti M, Goggs R. Plasma procalcitonin concentrations predict organ dysfunction and outcome in dogs with sepsis. BMC Vet Res. 2018;14(1):111. [CrossRef]
  • 19. Brkljacic M, Brkljacic I, Torti M, et al. The concentrations of the inflammatory markers the amino-terminal portion of C-type pronatriuretic peptide and procalcitonin in canine babesiosis caused by Babesia canis. Vet Arh. 2014;84:575-589.
  • 20. Sharma S, Pokharel. Diagnosis and Therapeutic Management of Mixed Demodex and Sarcoptes Mite Infestation in Dog. ASAG2019;3:6.
There are 20 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Sciences (Other)
Journal Section Research Articles
Authors

Yusuf Umut Batı This is me 0000-0001-7528-4376

Publication Date April 26, 2023
Published in Issue Year 2023 Volume: 18 Issue: 1

Cite

APA Batı, Y. U. (2023). Sarcoptes canis’le Doğal Enfeste Köpeklerde Serum Neopterin ve Prokalsitonin Seviyeleri. Veterinary Sciences and Practices, 18(1), 31-34.
AMA Batı YU. Sarcoptes canis’le Doğal Enfeste Köpeklerde Serum Neopterin ve Prokalsitonin Seviyeleri. Veterinary Sciences and Practices. April 2023;18(1):31-34.
Chicago Batı, Yusuf Umut. “Sarcoptes canis’le Doğal Enfeste Köpeklerde Serum Neopterin Ve Prokalsitonin Seviyeleri”. Veterinary Sciences and Practices 18, no. 1 (April 2023): 31-34.
EndNote Batı YU (April 1, 2023) Sarcoptes canis’le Doğal Enfeste Köpeklerde Serum Neopterin ve Prokalsitonin Seviyeleri. Veterinary Sciences and Practices 18 1 31–34.
IEEE Y. U. Batı, “Sarcoptes canis’le Doğal Enfeste Köpeklerde Serum Neopterin ve Prokalsitonin Seviyeleri”, Veterinary Sciences and Practices, vol. 18, no. 1, pp. 31–34, 2023.
ISNAD Batı, Yusuf Umut. “Sarcoptes canis’le Doğal Enfeste Köpeklerde Serum Neopterin Ve Prokalsitonin Seviyeleri”. Veterinary Sciences and Practices 18/1 (April 2023), 31-34.
JAMA Batı YU. Sarcoptes canis’le Doğal Enfeste Köpeklerde Serum Neopterin ve Prokalsitonin Seviyeleri. Veterinary Sciences and Practices. 2023;18:31–34.
MLA Batı, Yusuf Umut. “Sarcoptes canis’le Doğal Enfeste Köpeklerde Serum Neopterin Ve Prokalsitonin Seviyeleri”. Veterinary Sciences and Practices, vol. 18, no. 1, 2023, pp. 31-34.
Vancouver Batı YU. Sarcoptes canis’le Doğal Enfeste Köpeklerde Serum Neopterin ve Prokalsitonin Seviyeleri. Veterinary Sciences and Practices. 2023;18(1):31-4.

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