Parvoviral Enteritisli Köpeklerde Parvulyte Jelin® Etkinliğinin Araştırılması

Year 2024, Volume: 19 Issue: 3, 132 - 139, 29.12.2024

Derya Kamçici , Sercan Hüseyin Bayendur , Abuzer Acar

https://doi.org/10.17094/vetsci.1508361

Abstract

Bu çalışma Parvulyte®'nin parvoviral enteritisli köpeklerdeki etkinliğini göstermeyi amaçlamıştır. Çalışmanın hayvan materyalini, XX Üniversitesi Veteriner Sağlık Uygulama ve Araştırma Merkezi İç Hastalıkları Kliniği ve İzmir'deki özel veteriner kliniklerine getirilen, klinik muayene ve immunokromatografik hızlı test kitleri ile parvoviral enteritis tanısı konulan 14 köpek oluşturdu. Parvoviral enteritis tanısı konulduktan sonra birinci gruptaki köpeklere sıvı tedavisi ile birlikte vitamin-mineral-elektrolit-amino asit takviyesi, pantoprazol, sefazolin sodyum ve maropitant sitrat verildi (Grup I, n=7). İkinci gruptaki köpekler aynı tedavi protokolüne ek olarak Parvulyte® almıştır (Grup II, n=7). Her iki grup da 7 gün boyunca tedavi edilmiştir. Grup II'deki köpeklerin lenfosit sayısında artış, antikor titrelerinde daha hızlı bir artış ve oluşturulan dışkı skorlama tablosuna kıyasla daha hızlı bir klinik iyileşme olduğu gözlemlenmiştir. Sonuç olarak, Parvulyte® parvoviral enteritisli köpeklerde klinik iyileşmeyi hızlandırmış ve hastanede kalış süresini kısaltmıştır.

Keywords

CPV, köpek, parvoviral enterit, parvulyte

Supporting Institution

Afyon Kocatepe Üniversitesi Bilimsel Proje Araştırmaları Koordinasyon Birimi (BAPK)

Project Number

20.Sağ.Bİl.16

The Research of Effectiveness of Parvulyte Gel® in Dogs with Parvoviral Enteritis

Abstract

This study aimed to demonstrate the efficacy of Parvulyte® in dogs with parvoviral enteritis. The animal material of the study consisted of 14 dogs diagnosed with parvoviral enteritis due to clinical examination and immunochromatographic rapid test kits brought to XX University Veterinary Health Application and Research Center Internal Diseases Clinic and private veterinary clinics in Izmir. After the diagnosis of parvoviral enteritis, the dogs in the first group received fluid therapy along with vitamin-mineral-electrolyte-amino acid supplements, pantoprazole, cefazolin sodium and maropitant citrate (Group I, n=7). The dogs in the second group received Parvulyte® in addition to the same treatment protocol (Group II, n=7). Both groups were treated for 7 days. It was observed that the dogs in Group II had an increase in the lymphocyte count, a faster increase in antibody titers, and a faster clinical recovery compared to the stool scoring table created. As a result, Parvulyte® accelerated the clinical recovery and shortened the hospitalization time in dogs with parvoviral enteritis.

Keywords

Parvoviral enteritis, CPV, Dog, Parvulyte

Project Number

20.Sağ.Bİl.16

References

• 1.Tuteja D, Banu K, Mondal B. Canine parvovirology – A brief updated review on structural biology, occurrence, pathogenesis, clinical diagnosis, treatment and prevention. Comp Immunol Microbiol Infect Dis. 2022;101765.
• 2.Capozza P, Buonavoglia A, Pratelli A, Martella V, Decaro N. Old and Novel Enteric Parvoviruses of Dogs. Pathogens. 2023;12(5):722.
• 3.Jyothi VP, Bhaskaran MS, Gundi VA. Epidemiology, molecular prevalence and prevention on canine parvovirus in India: A review. Bioinformation. 2024;20(5):536-546.
• 4.Adeyemo AA, Aiki-Raji CO, Akinniyi OO, Fagbohun OA. Molecular epidemiology of Canine Parvovirus in Nigeria. Afr J Biomed Res. 2024;27:217-224.
• 5.Sykes JE. Canine Parvovirus Infectiıns and Other Viral Enteritides In: Sykes JE, eds. Canine and Feline Infectious Diseases. 1st ed. Elsevier, St Louis, 2014:141-151.
• 6.Mazzaferro EM. Update on Canine Parvoviral Enteritis. Vet Clin North Am Small Anim Pract. 2020;50(6):1307-1325.
• 7.Brady S, Norris JM, Kelman M, Ward MP. Canine parvovirus in Australia: The role of socio-economic factors in disease clusters. Vet J. 2012;193(2):522-528.
• 8.Zourkas E, Ward MP, Kelman M. Canine parvovirus in Australia: a comparative study of reported rural and urban cases. Vet Microbiol. 2015;181(3-4):198-203.
• 9.Kelman M, Ward MP, Barrs VR, Norris JM. The geographic distribution and financial impact of canine parvovirus in Australia. Transbound Emerg Dis. 2019;66(1):299-311.
• 10.Warr GW, Magor KE, Higgins DA. IgY: clues to the origin of modern antibodies. Immunol Today. 1995;16(8):392-398.
• 11.Narat M. Production of antibodies in chickens. Food Technol Biotechnol. 2003;41(3):259-267.
• 12.Michael A, Meenatchisundaram S, Parameswari G, Subbraj T, Selvakumaran R, Ramalingam S. Chicken egg yolk antibodies (IgY) as an alternative to mammalian antibodies. Indian J Sci Technol. 2010;3(4):468-474.
• 13.Pereira EPV, van Tilburg MF, Florean EOPT, Guedes MIF. Egg yolk antibodies (IgY) and their applications in human and veterinary health: A review. Int Immunopharmacol. 2019;73:293-303.
• 14.Lee DH, Jeon Y, Park C, Kim S, Lee DS, Lee C. Immunoprophylactic effect of chicken egg yolk antibody (IgY) against a recombinant S1 domain of the porcine epidemic diarrhea virus spike protein in piglets. Arch Virol. 2015;160(9):3197-2207.
• 15.Vega C, Bok M, Chacana P, Saif L, Fernandez F, Parreno V. Egg yolk IgY antibodies: a therapeutic intervention against group a rotavirus in calves. Res Vet Sci. 2015;103:1-10.
• 16.Fink AL, Williams KL, Harris E, Alvine TD, Henderson T, Schiltz J, et al. Dengue virus specific IgY provides protection following lethal dengue virus challenge and is neutralizing in the absence of inducing antibody dependent enhancement. PLoS Negl Trop Dis. 2017;11(7):1-17.
• 17.Nguyen HH, Tumpey TM, Park HJ, Byun YH, Tran LD, Nguyen V, et al. Prophylactic and Therapeutic Efficacy of Avian Antibodies Against Influenza Virus H5N1 and H1N1 in Mice. PLoS One. 2010;5(4):1-11.
• 18.Takeuchi S, Motohashi J, Kimori H, Nakagawa Y, Tsurumoto A. Effects of oral moisturising gel containing egg yolk antibodies against Candida albicans in older people. Gerodontology. 2015; 33(1):128-134.
• 19.Sampaio LCL, Baldissera MD, Grando TH, Gressler LT, Capeleto DM, de Sa MF, et al. Production, purification and therapeutic potential of egg yolk antibodies for treating Trypanosoma evansi infection. Vet Parasitol. 2014;204(3-4):96-103.
• 20.Miranda C, Thompson G. Canine parvovirus in vaccinated dogs: a field study. Vet Rec. 2016;178(16):397-402.
• 21.Cavalli A, Marinaro M, Desario C, Corrente M, Camero M, Buonavoglia C. In vitro virucidal activity of sodium hypochlorite against canine parvovirus type 2. Epidemiol Infect. 2018;146(15):2010-2013.
• 22.Terzungwe TM. Hematological parameters of dogs infected with Canine Parvovirus Enteritis in Sumy Ukraine. WJIR. 2018;5(3):1-5.
• 23.Goddard A, Leisewitz AL, Christopher MM, Duncan NM, Becker PJ. Prognostic usefulness of blood leukocyte changes in canine parvoviral enteritis. J Vet Intern Med. 2008;22:309-316.
• 24.Castro TX, De Cubel Garcia RCN, Gonçalves LRS, Costa EM, Marcello GCG, Labarthe NV, et al. Clinical, hematological, and biochemical findings in puppies with coronavirus and parvovirus enteritis. Can Vet J. 2013;54(9):885-888.
• 25.Liu S, Zhu X, Qiu Y, Wang L, Shang X, Gao K, et al. Effect of Niacin on Growth Performance, Intestinal Morphology, Mucosal Immunity and Microbiota Composition in Weaned Piglets. Animals (Basel). 2021;11(8):2186.
• 26.Skupsky J, Sabui S, Hwang M, Nakasaki M, Cahalan MD, Said HM. Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-κB Activation. Cell Mol Gastroenterol Hepatol. 2020;9(4):557-567.
• 27.Goudez R, Weber M, Biourge V, Nguyen P. Influence of different levels and sources of resistant starch on faecal quality of dogs of various body sizes. Br J Nutr. 2011;106 (Suppl 1): S211-215.
• 28.Karthikeyan M, Indhuprakash ST, Gopal G, Ambi SV, Krishnan UM, Diraviyam T. Passive immunotherapy using chicken egg yolk antibody (IgY) against diarrheagenic E. coli: A systematic review and meta-analysis. Int Immunopharmacol. 2022;102:108381.
• 29.Suartini GAA, Suprayogi A, Wibawan WT, Sendow I, Mahardika GN. Intravenous administration of chicken immunoglobulin has a curative effect in experimental infection of Canine Parvovirus. Glob Vet. 2014;13(5):801-808.