Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü

Nurettin Onur Kutlu; İlhan Yaylım

Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü

Öz

Hypoxia-Inducible Factor-1 alpha, oksijen seviyelerine karşı hücresel yanıtta merkezi bir rol oynayan kritik bir transkripsiyon faktörüdür. HIF-1α, ökaryotlar ve tüm omurgalı/ omurgasız canlıların tümünde oksijensiz ortamda hücresel düzeyde adaptasyon sağlanmasında görevlidir. On beş kromozomda yüzden fazla gene bağlanma noktaları olduğu belirlenmiştir. Metabolizma, anjiyogenez, hematopoez, epitel hücrelerinin çoğalması ve göçü, eritropoez, bağışıklık, inflamasyon, kanser, epigenetik düzenlenme, apoptosis ve otofajide kritik bir rol oynar. Bu derlemede, HIF-1α'nın yapısı, düzenlenmesi ile hipoksi, yangı, yaralanma, iskemi ve kanser gibi patolojik süreçlerle olan etkileşimlerini son bilimsel gelişmeler ışığında sunmayı amaçlıyoruz.

Anahtar Kelimeler

HIF-1 alfa, hipoksi, anjiogenez, metabolizma, yangı, kanser, iskemi

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Yardımcı Sağlık ve Rehabilitasyon Bilimi (Diğer)

Bölüm

Derleme

Yazarlar

Nurettin Onur Kutlu ^*
Türkiye

İlhan Yaylım
Türkiye

Yayımlanma Tarihi

30 Nisan 2024

Gönderilme Tarihi

17 Ekim 2023

Kabul Tarihi

18 Nisan 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 5 Sayı: 2

IZ

https://izlik.org/JA82SR95UF

APA

Kutlu, N. O., & Yaylım, İ. (2024). Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü. Yeni Yüzyıl Journal of Medical Sciences, 5(2), 48-55. https://izlik.org/JA82SR95UF

AMA

1.Kutlu NO, Yaylım İ. Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü. JMS. 2024;5(2):48-55. https://izlik.org/JA82SR95UF

Chicago

Kutlu, Nurettin Onur, ve İlhan Yaylım. 2024. “Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü”. Yeni Yüzyıl Journal of Medical Sciences 5 (2): 48-55. https://izlik.org/JA82SR95UF.

EndNote

Kutlu NO, Yaylım İ (01 Nisan 2024) Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü. Yeni Yüzyıl Journal of Medical Sciences 5 2 48–55.

IEEE

[1]N. O. Kutlu ve İ. Yaylım, “Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü”, JMS, c. 5, sy 2, ss. 48–55, Nis. 2024, [çevrimiçi]. Erişim adresi: https://izlik.org/JA82SR95UF

ISNAD

Kutlu, Nurettin Onur - Yaylım, İlhan. “Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü”. Yeni Yüzyıl Journal of Medical Sciences 5/2 (01 Nisan 2024): 48-55. https://izlik.org/JA82SR95UF.

JAMA

1.Kutlu NO, Yaylım İ. Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü. JMS. 2024;5:48–55.

MLA

Kutlu, Nurettin Onur, ve İlhan Yaylım. “Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü”. Yeni Yüzyıl Journal of Medical Sciences, c. 5, sy 2, Nisan 2024, ss. 48-55, https://izlik.org/JA82SR95UF.

Vancouver

1.Nurettin Onur Kutlu, İlhan Yaylım. Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü. JMS [Internet]. 01 Nisan 2024;5(2):48-55. Erişim adresi: https://izlik.org/JA82SR95UF