Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler

Tuğçe Küçükali; Hande Erensoy; Serap Ayaz Seyhan; Dilek Bilgiç Alkaya

EN TR

Hydroxyapatite–Glucosamine–Chondroitin Sulfate Composites: Current Trends in Bone Regeneration

Öz

Bone regeneration remains a significant clinical challenge in orthopedics, particularly in the treatment of critical-sized defects where the bone's natural healing capacity is insufficient. Hydroxyapatite (HAp), a calcium phosphate ceramic that closely mimics the mineral phase of natural bone, is widely used due to its excellent biocompatibility and osteoconductive properties. However, its brittleness and limited mechanical strength restrict its application. To overcome these limitations, biologically active glycosaminoglycans such as glucosamine (GS) and chondroitin sulfate (CS) have emerged as a promising strategy. These biomolecules not only play a crucial role in extracellular matrix organization but also actively regulate cellular processes such as osteoblast proliferation and inflammation. This review evaluates recent advances in HA–GS–CS-based composite systems, focusing on their design, structure, and biological performance.

Anahtar Kelimeler

Hydroxyapatite, Glucosamine, Chondroitin sulfate, Nanocomposite

Destekleyen Kurum

Marmara University Scientific Research Project Directorate

Proje Numarası

TYL-2024- 11290

Etik Beyan

No ethical approval is required.

Teşekkür

This study was financially supported by the Marmara University Scientific Research Committee under project number TYL-2024-11290.

Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler

Öz

Kemik rejenerasyonu, özellikle kemiğin doğal iyileşme kapasitesinin yetersiz olduğu kritik büyüklükteki defektlerin tedavisinde, ortopedi de önemli bir klinik zorluk olmaya devam etmektedir. Doğal kemiğin mineral fazını yakından taklit eden bir kalsiyum fosfat seramiği olan hidroksiapatit (HAp), mükemmel biyo-uyumluluğu ve osteokondüktif özellikleri nedeniyle yaygın olarak kullanılmaktadır. Bununla birlikte, kırılganlığı ve sınırlı mekanik dayanıklılığı uygulamasını kısıtlamaktadır. Bu sınırlamaların üstesinden gelmek için, glukozamin (GS) ve kondroitin sülfat (CS) gibi biyolojik olarak aktif glikozaminoglikanların ile umut vadeden bir strateji olarak ortaya çıkmıştır. Bu biyomoleküller sadece hücre dışı matris organizasyonunda önemli bir rol oynamakla kalmaz, aynı zamanda osteoblast proliferasyonu, ve inflamasyon gibi hücresel süreçleri aktif olarak düzenlemektedir

Anahtar Kelimeler

Hidroksiapatit, Glukozamin, Kondroitin sülfat, Nanokompozit

Destekleyen Kurum

Marmara Üniversitesi Bilimsel Araştırma Proje Başkanlığı

Proje Numarası

TYL-2024- 11290

Etik Beyan

Etik izne gerek yoktur.

Teşekkür

Çalışma, Marmara Üniversitesi Bilimsel Araştırma Komitesi tarafından TYL-2024- 11290 numaralı proje kapsamında mali olarak desteklenmiştir

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Yardımcı Sağlık ve Rehabilitasyon Bilimi (Diğer)

Bölüm

Derleme

Yazarlar

Tuğçe Küçükali
0009-0000-6348-5031
Türkiye

Hande Erensoy
0000-0003-0643-9199
Türkiye

Serap Ayaz Seyhan
0000-0001-5908-2766
Türkiye

Dilek Bilgiç Alkaya ^*
0000-0002-7837-0250
Türkiye

Yayımlanma Tarihi

29 Temmuz 2026

Gönderilme Tarihi

30 Nisan 2026

Kabul Tarihi

17 Haziran 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 7 Sayı: 3

IZ

https://izlik.org/JA64SH73XZ

APA

Küçükali, T., Erensoy, H., Ayaz Seyhan, S., & Bilgiç Alkaya, D. (2026). Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler. Yeni Yüzyıl Journal of Medical Sciences, 7(3), 93-105. https://izlik.org/JA64SH73XZ

AMA

1.Küçükali T, Erensoy H, Ayaz Seyhan S, Bilgiç Alkaya D. Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler. JMS. 2026;7(3):93-105. https://izlik.org/JA64SH73XZ

Chicago

Küçükali, Tuğçe, Hande Erensoy, Serap Ayaz Seyhan, ve Dilek Bilgiç Alkaya. 2026. “Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler”. Yeni Yüzyıl Journal of Medical Sciences 7 (3): 93-105. https://izlik.org/JA64SH73XZ.

EndNote

Küçükali T, Erensoy H, Ayaz Seyhan S, Bilgiç Alkaya D (01 Temmuz 2026) Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler. Yeni Yüzyıl Journal of Medical Sciences 7 3 93–105.

IEEE

[1]T. Küçükali, H. Erensoy, S. Ayaz Seyhan, ve D. Bilgiç Alkaya, “Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler”, JMS, c. 7, sy 3, ss. 93–105, Tem. 2026, [çevrimiçi]. Erişim adresi: https://izlik.org/JA64SH73XZ

ISNAD

Küçükali, Tuğçe - Erensoy, Hande - Ayaz Seyhan, Serap - Bilgiç Alkaya, Dilek. “Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler”. Yeni Yüzyıl Journal of Medical Sciences 7/3 (01 Temmuz 2026): 93-105. https://izlik.org/JA64SH73XZ.

JAMA

1.Küçükali T, Erensoy H, Ayaz Seyhan S, Bilgiç Alkaya D. Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler. JMS. 2026;7:93–105.

MLA

Küçükali, Tuğçe, vd. “Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler”. Yeni Yüzyıl Journal of Medical Sciences, c. 7, sy 3, Temmuz 2026, ss. 93-105, https://izlik.org/JA64SH73XZ.

Vancouver

1.Tuğçe Küçükali, Hande Erensoy, Serap Ayaz Seyhan, Dilek Bilgiç Alkaya. Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler. JMS [Internet]. 01 Temmuz 2026;7(3):93-105. Erişim adresi: https://izlik.org/JA64SH73XZ

Hydroxyapatite–Glucosamine–Chondroitin Sulfate Composites: Current Trends in Bone Regeneration

Öz

Anahtar Kelimeler

Destekleyen Kurum

Proje Numarası

Etik Beyan

Teşekkür

Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler

Öz

Anahtar Kelimeler

Destekleyen Kurum

Proje Numarası

Etik Beyan

Teşekkür

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

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