Research Article
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The Mathematical Outcome of The IVF, Including Early Cleavage

Year 2023, Volume: 4 Issue: 3, 110 - 116, 08.08.2023

Abstract

Aim: In this manuscript, the examination of independent factors for the success of IVF (In Vitro Fertilization) was aimed
to be conducted.
Material and Methods: Hormones, including Anti-Mullerian
Hormone (AMH), Follicle Stimulating Hormone(FSH), the
growth stages of the oocyte that turns into an embryo (total
fertilized oocyte, early cleavage, etc.), the medical adjustments
were included. Our dependent factor, the success of fertilization, was categorized into two groups; in other words, binary
logistic regression for pregnancy success was examined.
Results: For the statistical significance of our study, Omnibus
Tests of Model Coefficients (p-value=0,008) and Hosmer and
Lemeshow tests (p-value=0,462) were conducted. Our model
was successful through statistical meaningfulness. With a ChiSquare test with a p-value of close to zero, women’s age groups
were proven different for groups below and over the age of 35
for InVitro Fertilization (IVF)
Discussion and conclusion: Study shows Early Segmentation
increases the chances of pregnancy; In contrast, the woman's
age and FSH reduce the likelihood of pregnancy.

References

  • 1. Zhang J, Wang C, Zhang H, Zhou Y. Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review. Reprod Biol Endocrinol. 2021 Sep 14;19(1):142. doi: 10.1186/s12958-021-00824-y. PMID: 34521412; PMCID: PMC8439041.
  • 2. Lundin K, Bergh C, & Hardarson T. Early embryo cleavage is a strong indicator of embryo quality in human IVF. Hum Reprod. 2001 Dec; 16(12):2652-7. doi: 10.1093/ humrep/16.12.2652. PMID: 11726590.
  • 3. Van Marion ES, Baart EB, Santos M, van Duijn L, van Santbrink EJP, Steegers-Theunissen RPM, Laven JSE, & Eijkemans MJC. Using the embryo-uterus statistical model to predict pregnancy chances by using cleavage stage morphokinetics and female age: two centre-specific prediction models and mutual validation. Reprod Biol Endocrinol. 2023 Mar 27; 21(1):31. doi: 10.1186/s12958-023-01076-8. PMID: 36973721; PMCID: PMC10041771.
  • 4. FISHER, R. A. “STUDENT”.1939, Annals of Eugenics, 9: 1–9. doi:10.1111/j.1469- 1809.1939.tb02192.x
  • 5. Guyatt G., Jaeschke R., Heddle N., et al. Basic statistics for clinicians: 1. hypothesis testing. CMAJ. 1995;152(1):27–32.
  • 6. Dodson W. C., Whitesides D. B., Hughes C. L., Easley H. A., Haney A. F. Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilization. Fertility and sterility, 1987; 48(3):441-445.
  • 7. Duran, E. H., Gürgan, T., Günalp, S., Enginsu, M. E., Yarali, H., & Ayhan, A. A logistic regression model including DNA status and morphology of spermatozoa for prediction of fertilization in vitro. Human reproduction (Oxford, England). 1998; 13(5): 1235-1239.
  • 8. Cai S, Natarajan P, Chan JKY, Wong PC, Tan KH, Godfrey KM, Gluckman PD, Shek LPC, Yap F, Kramer MS, Chan SY, Chong YS. Maternal hyperglycemia in singleton pregnancies conceived by IVF may be modified by first-trimester BMI. Hum Reprod. 2017 Sep 1;32(9):1941-1947. doi: 10.1093/humrep/dex243. PMID: 28854717; PMCID: PMC5638004.
  • 9. Lekamge D. N., Barry M., Kolo M., Lane M., Gilchrist R. B., Tremellen K. P. Anti-Mül-lerian hormone as a predictor of IVF outcome. Reproductive Biomedicine Online; 2007; 14(5): 602-610.
  • 10. Bos-Mikich A., Mattos A. L. G., Ferrari A. N. Early cleavage of human embryos: an effective method for predicting successful IVF/ICSI outcome. Human Reproduction. 2001; 16(12): 2658-2661.
  • 11. Nagakawa S., Schielzeth H. Repeatability for Gaussian and non‐Gaussian data: a practical guide for biologists. Biological Reviews, 2010; 85(4): 935-956.
  • 12. Peng, C. Y. J., Lee, K. L., & Ingersoll, G. M. (2002). An introduction to logistic regression analysis and reporting. The journal of educational research. 2002; 96(1): 3-14.
  • 13. Palomba, S., Daolio, J., & La Sala, G. B. Oocyte competence in women with polycystic ovary syndrome. Trends in Endocrinology & Metabolism. 2016; 28(3): 186 - 198
  • 14. Levin, D., Jun S. H., Dahan, M. H. Predicting pregnancy in women undergoing in-vitro fertilization with basal serum follicle stimulating hormone levels between 10.0 and 11.9 IU/L. Journal of the Turkish German Gynecological Association, 2015; 16(1): 5-10
  • 15. Klein N. A., Illingworth P. J., Groome N. P., McNeilly A. S., Battaglia D. E., Soules, M. R. Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. The Journal of Clinical Endocrinology & Metabolism, 1996; 81(7): 2742-2745.
  • 16. Ebbiary N. A., Lenton, E.A., Cooke I. D. Hypothalamic‐pituitary ageing: progressive increase in FSH and LH concentrations throughout the reproductive life in regularly menstruating women. Clinical endocrinology, 1994; 41(2): 199-206.
  • 17. Scott R. T., Toner, J. P., Muasher S. J., Oehninger S., Robinson S., & Rosenwaks Z. Follicle- stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome. Fertility and sterility, 1989; 51(4): 651-654.
  • 18. Yao L., Zhang W., Li, H., & Lin W. The role of serum AMH and FF AMH in predicting pregnancy outcome in the fresh cycle of IVF/ICSI: a meta-analysis. International Journal of Clinical and Experimental Medicine. 2015; 8(2): 1755-1767.
  • 19. Gardner D. K., Surrey E., Minjarez D., Leitz, A., Stevens J., Schoolcraft W. B. Single blastocyst transfer: a prospective randomized trial. Fertility and sterility. 2004; 81(3):551-555.
  • 20. Fenwick J., Platteau P., Murdoch A. P., Herbert M. Time from insemination to first cleavage predicts developmental competence of human preimplantation embryos in vitro. Human Reproduction, 2002; 17(2):407-412..
  • 21. Gardner D. K., Schoolcraft W. B., Wagley L., Schlenker T., Stevens J., & Hesla, J. A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization. Human reproduction (Oxford, England), 1998; 13(12): 3434-3440.
  • 22. Lee M.J., Lee R. K.K., Lin M.H., Hwu Y.M. Cleavage speed and implantation potential of early-cleavage embryos in IVF or ICSI cycles”. Journal of Assisted Reproduction and Genetics, 2012; 29(8): 745–750.
Year 2023, Volume: 4 Issue: 3, 110 - 116, 08.08.2023

Abstract

References

  • 1. Zhang J, Wang C, Zhang H, Zhou Y. Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review. Reprod Biol Endocrinol. 2021 Sep 14;19(1):142. doi: 10.1186/s12958-021-00824-y. PMID: 34521412; PMCID: PMC8439041.
  • 2. Lundin K, Bergh C, & Hardarson T. Early embryo cleavage is a strong indicator of embryo quality in human IVF. Hum Reprod. 2001 Dec; 16(12):2652-7. doi: 10.1093/ humrep/16.12.2652. PMID: 11726590.
  • 3. Van Marion ES, Baart EB, Santos M, van Duijn L, van Santbrink EJP, Steegers-Theunissen RPM, Laven JSE, & Eijkemans MJC. Using the embryo-uterus statistical model to predict pregnancy chances by using cleavage stage morphokinetics and female age: two centre-specific prediction models and mutual validation. Reprod Biol Endocrinol. 2023 Mar 27; 21(1):31. doi: 10.1186/s12958-023-01076-8. PMID: 36973721; PMCID: PMC10041771.
  • 4. FISHER, R. A. “STUDENT”.1939, Annals of Eugenics, 9: 1–9. doi:10.1111/j.1469- 1809.1939.tb02192.x
  • 5. Guyatt G., Jaeschke R., Heddle N., et al. Basic statistics for clinicians: 1. hypothesis testing. CMAJ. 1995;152(1):27–32.
  • 6. Dodson W. C., Whitesides D. B., Hughes C. L., Easley H. A., Haney A. F. Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilization. Fertility and sterility, 1987; 48(3):441-445.
  • 7. Duran, E. H., Gürgan, T., Günalp, S., Enginsu, M. E., Yarali, H., & Ayhan, A. A logistic regression model including DNA status and morphology of spermatozoa for prediction of fertilization in vitro. Human reproduction (Oxford, England). 1998; 13(5): 1235-1239.
  • 8. Cai S, Natarajan P, Chan JKY, Wong PC, Tan KH, Godfrey KM, Gluckman PD, Shek LPC, Yap F, Kramer MS, Chan SY, Chong YS. Maternal hyperglycemia in singleton pregnancies conceived by IVF may be modified by first-trimester BMI. Hum Reprod. 2017 Sep 1;32(9):1941-1947. doi: 10.1093/humrep/dex243. PMID: 28854717; PMCID: PMC5638004.
  • 9. Lekamge D. N., Barry M., Kolo M., Lane M., Gilchrist R. B., Tremellen K. P. Anti-Mül-lerian hormone as a predictor of IVF outcome. Reproductive Biomedicine Online; 2007; 14(5): 602-610.
  • 10. Bos-Mikich A., Mattos A. L. G., Ferrari A. N. Early cleavage of human embryos: an effective method for predicting successful IVF/ICSI outcome. Human Reproduction. 2001; 16(12): 2658-2661.
  • 11. Nagakawa S., Schielzeth H. Repeatability for Gaussian and non‐Gaussian data: a practical guide for biologists. Biological Reviews, 2010; 85(4): 935-956.
  • 12. Peng, C. Y. J., Lee, K. L., & Ingersoll, G. M. (2002). An introduction to logistic regression analysis and reporting. The journal of educational research. 2002; 96(1): 3-14.
  • 13. Palomba, S., Daolio, J., & La Sala, G. B. Oocyte competence in women with polycystic ovary syndrome. Trends in Endocrinology & Metabolism. 2016; 28(3): 186 - 198
  • 14. Levin, D., Jun S. H., Dahan, M. H. Predicting pregnancy in women undergoing in-vitro fertilization with basal serum follicle stimulating hormone levels between 10.0 and 11.9 IU/L. Journal of the Turkish German Gynecological Association, 2015; 16(1): 5-10
  • 15. Klein N. A., Illingworth P. J., Groome N. P., McNeilly A. S., Battaglia D. E., Soules, M. R. Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. The Journal of Clinical Endocrinology & Metabolism, 1996; 81(7): 2742-2745.
  • 16. Ebbiary N. A., Lenton, E.A., Cooke I. D. Hypothalamic‐pituitary ageing: progressive increase in FSH and LH concentrations throughout the reproductive life in regularly menstruating women. Clinical endocrinology, 1994; 41(2): 199-206.
  • 17. Scott R. T., Toner, J. P., Muasher S. J., Oehninger S., Robinson S., & Rosenwaks Z. Follicle- stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome. Fertility and sterility, 1989; 51(4): 651-654.
  • 18. Yao L., Zhang W., Li, H., & Lin W. The role of serum AMH and FF AMH in predicting pregnancy outcome in the fresh cycle of IVF/ICSI: a meta-analysis. International Journal of Clinical and Experimental Medicine. 2015; 8(2): 1755-1767.
  • 19. Gardner D. K., Surrey E., Minjarez D., Leitz, A., Stevens J., Schoolcraft W. B. Single blastocyst transfer: a prospective randomized trial. Fertility and sterility. 2004; 81(3):551-555.
  • 20. Fenwick J., Platteau P., Murdoch A. P., Herbert M. Time from insemination to first cleavage predicts developmental competence of human preimplantation embryos in vitro. Human Reproduction, 2002; 17(2):407-412..
  • 21. Gardner D. K., Schoolcraft W. B., Wagley L., Schlenker T., Stevens J., & Hesla, J. A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization. Human reproduction (Oxford, England), 1998; 13(12): 3434-3440.
  • 22. Lee M.J., Lee R. K.K., Lin M.H., Hwu Y.M. Cleavage speed and implantation potential of early-cleavage embryos in IVF or ICSI cycles”. Journal of Assisted Reproduction and Genetics, 2012; 29(8): 745–750.
There are 22 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences (Other)
Journal Section Research Articles
Authors

Simge Or This is me 0000-0002-4607-7199

Pelin Öçal This is me 0000-0002-7531-5942

Nurten Dayıoglu This is me 0000-0002-4598-4678

Tülay İrez This is me

Publication Date August 8, 2023
Submission Date April 7, 2023
Published in Issue Year 2023 Volume: 4 Issue: 3

Cite

AMA Or S, Öçal P, Dayıoglu N, İrez T. The Mathematical Outcome of The IVF, Including Early Cleavage. JMS. August 2023;4(3):110-116.