The effect of patient’s age on oncologic and survival results in patients undergoing radical cystectomy due to muscle invasive bladder cancer

Year 2018, Volume: 13 Issue: 2, 48 - 52, 01.06.2018

Ertuğrul Şefik , Serdar Çelik İsmail Basmacı Bülent Günlüsoy Serkan Yarımoğlu Tarık Yonguç İbrahim Halil Bozkurt Çetin Dinçel

Abstract

Purpose: To investigate the effect of age on oncologic and survival results in patients undergoing radical cystectomy due to muscle invasive bladder cancer. 

Material and Method: We reviewed the data of 178 patients who underwent radical cystectomy between January 2006 and November 2016 due to bladder cancer in our clinic. Finally 147 patients who underwent radical cystectomy due to muscle-invasive bladder cancer were included in the study. Patients were divided into two groups as; patient age ≤ 70 years (Group 1) and > 70 years (Group 2). Then we compared the groups in terms of preoperative data, oncological outcomes and survival findings. 

Results: There were 101 and 46 patients in group 1 and group 2 respectively. There was no statistically significant difference between the two groups in terms of gender, preoperative T stage, tumor grade, preoperative hydronephrosis and precence of carcinoma in situ (CIS). Preoperative ASA score was higher in the elderly group (Group 2) (p = 0.007). Postoperative data showed that the presence of variant histology, T stage, upstaging, tumor grade, lymph node metastasis, positive surgical margins were similar between the two groups. There was no statistically significant difference between the two groups in terms of overall survival and cancer-specific survival. 

Conclusion : There was no statistically significant difference between oncologic and survival findings between ≤ 70 years and > 70 years old patients who underwent radical cystectomy due to muscle invasive bladder cancer. 

Keywords

bladder cancer , age , radical cystectomy

Kas invaziv mesane kanseri nedeniyle radikal sistektomi yapılan hastalarda hasta yaşının onkolojik ve sağkalım sonuçları üzerine etkisi

Abstract

Amaç : Kas invaziv mesane kanseri nedeniyle radikal sistektomi yapılan hastalarda hasta yaşının onkolojik ve sağkalım verileri üzerine etkisini araştırmak 

Gereç ve Yöntemler : Kliniğimizde mesane kanseri nedeniyle Ocak 2006-Kasım 2016 tarihleri arasında radikal sistektomi operasyonu yapılan 178 hastaya ait veriler incelendi. Çalışmaya kas invaziv mesane kanseri nedeniyle radikal sistektomi yapılan 147 hasta dahil edildi. Hastalar ≤ 70 yaş(Grup 1) ve >70 yaş (Grup 2) olmak üzere iki gruba ayrıldı. Bu iki grup preoperatif veriler, onkolojik sonuçlar ve sağkalım verileri açısından karşılaştırıldı. 

Bulgular : Grup 1 de 101 hasta, grup 2 de ise 46 hasta vardı. İki grup arasında cinsiyet, preoperatif T evresi, tümör grade i, preoperatif hidronefroz ve karsinoma in situ (CIS) varlığı açısından istatistiksel anlamlı fark yoktu. Preoperatif ASA skoru yaşlı grupta(Grup 2) daha yüksekti(p=0.007). Postoperatif verilerde varyant histoloji varlığı, T evresi, upstaging, tümör grade i, lenf nodu metastazı ve pozitif cerrahi sınır varlığı iki grup arasında benzer olarak bulundu. İki grup arasında genel sağkalım ve kanser spesifik sağkalım açısından istatistiksel anlamlı fark izlenmedi. 

Sonuç: Kas invaziv mesane tümörü nedeniyle radikal sistektomi yapılan ≤ 70 yaş ve >70 yaş hasta grupları arasında onkolojik ve sağkalım verileri açısından istatistiksel anlamlı fark izlenmedi. 

Keywords

mesane kanseri; , yaş , radikal sistektomi

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