Our mid-term follow-up results in bladder tumors below 40 years of age
Abstract
Purpose: Urothelial tumors are rarely seen in young patients. Therefore in these types of patients, information related to natural course of the disease are not clear-cut and patients who will be evaluated in the young age category have not been defined yet. In our study, based on our small series, we aimed to predict the natural course of the bladder tumor seen in young patients peculiar to this age group.
Material and Methods: A total of 15 patients aged between 18-40 years who consulted to our urology clinic between January 2012 and January 2017 were retrospectively evaluated. Our cases were analyzed by demographic data (age and gender), smoking history, tumor type, grade, stage, number of foci, tumor recurrence and intravesical treatment parameters and dividing into two groups of under age 30 and age range 30-40 years.
Results: Our cases were either below (n=7; 46.7 %) or above (n=8; 53.3 %) 30 years of age. The rates of low grade tumors in the age group of ≤ 30 years were found to be higher when compared with the age group of > 30 years (p:0.007; p<0.01).
Conclusion: In our study, when patients
were evaluated as those aged < 30 and > 30
years, age factor was observed to be a potentially
negative predictive factor directly correlated
with tumor size, histopathological grade
and stage, treatment responses to intravesical
therapy and tumor recurrence.
Keywords
References
- 1. Howlader N, Noone AM, Krapcho M. SEER Cancer Statistics Review, Bladder Section, 1975–2008. Bethesda, MD: National Cancer Institute.
- 2. Fine SW, Humphrey PA, Dehner LP, Amin MB, Epstein JI. Urothelial neoplasms in patients 20 years or younger: a clinicopathological analysis using the World Health Organization 2004 Bladder Consensus Classification. J Uro. 2005; 174:1976–80.
- 3. Migaldi M, Rossi G, Maiorana G, Sartori G, Ferrari P, De Gaetani C, et al. Superficial papillary urothelial carcinomas in young and elderly patients: a comparative study. BJU Int 2004; 94:311–6.
- 4. Yossepowitch O, Dalbagni G. Transitional cell carcinoma of the bladder in young adults: presentation, natural history and outcome. J Urol 2002; 168:61–6.
- 5. Telli O, Sarici H, Ozgur BC, Doluoglu OG, Sunay MM, Bozkurt S, et al. Urothelial cancer of bladder in young versus older adults: clinical and pathological characteristics and outcomes. Kaohsiung J Med Sci 2014; 30:466-70.
- 6. Wen YC, Kuo JY, Chen KK, Lin AT, Chang YH, Hsu YS, et al. Urothelial carcinoma of the urinary bladder in young adults- Clinical experience at Taipei Veterans General Hospital. Journal of the Chinese Medical Association 2005;68:272-5.
- 7. Owen HC, Giedl J, Wild PJ, Fine SW, Humphrey PA, Dehner LP, et al. Low frequency of epigenetic events in urothelial tumors in young patients. J Urol 2010; 184:459–46.
- 8. Greenfield SP, Williot P, Kaplan D. Gross hematuria in children: a ten year review. Urology 2007; 69:166–9.
Details
Primary Language
English
Subjects
Surgery
Journal Section
Research Article
Authors
Fatih Uruç
*
This is me
Türkiye
Serkan Akan
This is me
Türkiye
Bekir Aras
This is me
Türkiye
Özgür Haki Yüksel
This is me
Türkiye
Aytaç Şahin
This is me
Türkiye
Ayhan Verit
This is me
Türkiye
Publication Date
June 1, 2018
Submission Date
August 9, 2017
Acceptance Date
September 28, 2017
Published in Issue
Year 2018 Volume: 13 Number: 2