Research Article
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40 yaş altı mesane tümörlerinde orta dönem takip sonuçlarımız

Year 2018, Volume: 13 Issue: 2, 20 - 25, 01.06.2018

Abstract

Amaç: Ürotelyal tümörler genç hastalarda
nadiren görülür. Bu nedenle genç hastalarda
hastalığın doğal seyri ile ilgili bilgiler net değildir ve bu kategoride değerlendirilecek hastalar
henüz tanımlanmamıştır. Çalışmamızda,
küçük serilerimize dayanarak genç hastalarda
görülen mesane tümörünün doğal seyrini öngörmeyi
amaçladık.

Gereç ve Yöntemler: Ocak 2012 ile Ocak
2017 arasında üroloji kliniğine başvuran 18-
40 yaşları arasındaki toplam 15 hasta geriye
dönük olarak değerlendirildi. Olgularımız demografik
veriler (yaş ve cinsiyet), sigara öyküsü, tümör tipi, grade, evre, odak sayısı, tümör
rekürrensi ve intravezikal tedavi parameterleri
değerlendirilerek 30 yaş altı ve 30-40 yaş
aralığı olmak üzere iki ayrı gruba ayrılayarak
analiz edildi

Bulgular: Olgularımız 30 yaşın altındaki
(n = 7; % 46.7) veya üzeri (n = 8; % 53.3) idi.
Otuz yaşın altındaki düşük dereceli tümörlerin
oranları 30 yaşın üzerindeki yaş grubuna
göre daha yüksek bulundu (p: 0.007; p <0.01).

Sonuç: Çalışmamızda, hastalar < 30 ve
> 30 yaş hastalar olarak değerlendirildiğinde,
yaş faktörünün, tümör boyutu, histopatolojik
grade ve evre, intravezikal tedaviye verilen
tedavi yanıtları ve tümör rekürrensi ile doğrudan korelasyona sahip potansiyel olarak negatif
bir prediktif faktör olduğu gözlemlendi.

References

  • 1. Howlader N, Noone AM, Krapcho M. SEER Cancer Statistics Review, Bladder Section, 1975–2008. Bethesda, MD: National Cancer Institute.
  • 2. Fine SW, Humphrey PA, Dehner LP, Amin MB, Epstein JI. Urothelial neoplasms in patients 20 years or younger: a clinicopathological analysis using the World Health Organization 2004 Bladder Consensus Classification. J Uro. 2005; 174:1976–80.
  • 3. Migaldi M, Rossi G, Maiorana G, Sartori G, Ferrari P, De Gaetani C, et al. Superficial papillary urothelial carcinomas in young and elderly patients: a comparative study. BJU Int 2004; 94:311–6.
  • 4. Yossepowitch O, Dalbagni G. Transitional cell carcinoma of the bladder in young adults: presentation, natural history and outcome. J Urol 2002; 168:61–6.
  • 5. Telli O, Sarici H, Ozgur BC, Doluoglu OG, Sunay MM, Bozkurt S, et al. Urothelial cancer of bladder in young versus older adults: clinical and pathological characteristics and outcomes. Kaohsiung J Med Sci 2014; 30:466-70.
  • 6. Wen YC, Kuo JY, Chen KK, Lin AT, Chang YH, Hsu YS, et al. Urothelial carcinoma of the urinary bladder in young adults- Clinical experience at Taipei Veterans General Hospital. Journal of the Chinese Medical Association 2005;68:272-5.
  • 7. Owen HC, Giedl J, Wild PJ, Fine SW, Humphrey PA, Dehner LP, et al. Low frequency of epigenetic events in urothelial tumors in young patients. J Urol 2010; 184:459–46.
  • 8. Greenfield SP, Williot P, Kaplan D. Gross hematuria in children: a ten year review. Urology 2007; 69:166–9.
  • 9. Mueller CM, Caporaso N, Greene MH. Familial and genetic risk of transitional cell carcinoma of the urinary tract. Urol Oncol 2008; 26:451–64.
  • 10. Williamson SR, Wang M, Montironi R, Eble JN, Lopez- Beltran A, Zhang S, et al. Molecular characteristics of urothelial neoplasms in children and young adults: a subset of tumors from young patients harbors chromosomal abnormalities but not FGFR3 or TP53 gene mutations. Mod Pathol 2014; 27:1540-8.
  • 11. Paner GP, Zehnder P, Amin AM, Husain AN, Desai MM. Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients: a comprehensive review of literature with implications for patient management. Adv Anat Patho. 2011; 18:79-89.
  • 12. Lezama–del Valle P, Jerkins GR, Rao BN, Santana VM, Fuller C, Merchant TE. Aggressive bladder carcinoma in a child. Pediatr Blood Cancer 2004; 43:285–8.
  • 13. Scott AA, Stanley W, Worsham GF, Kirkland TA Jr, Gansler T, Garvin AJ. Aggressive bladder carcinoma in an adolescent. Report of a case with immunohistochemical, cytogenetic, and flow cytometric characterization. Am J Surg Pathol 1989; 13:1057–63.

Our mid-term follow-up results in bladder tumors below 40 years of age

Year 2018, Volume: 13 Issue: 2, 20 - 25, 01.06.2018

Abstract

Purpose: Urothelial tumors are rarely
seen in young patients. Therefore in these
types of patients, information related to natural
course of the disease are not clear-cut and
patients who will be evaluated in the young
age category have not been defined yet. In our
study, based on our small series, we aimed to
predict the natural course of the bladder tumor
seen in young patients peculiar to this age
group.

Material and Methods: A total of 15
patients aged between 18-40 years who consulted
to our urology clinic between January
2012 and January 2017 were retrospectively
evaluated. Our cases were analyzed by demographic
data (age and gender), smoking history,
tumor type, grade, stage, number of foci,
tumor recurrence and intravesical treatment
parameters and dividing into two groups of
under age 30 and age range 30-40 years.

Results: Our cases were either below
(n=7; 46.7 %) or above (n=8; 53.3 %) 30 years
of age. The rates of low grade tumors in the age
group of ≤ 30 years were found to be higher
when compared with the age group of > 30
years (p:0.007; p<0.01).

Conclusion: In our study, when patients
were evaluated as those aged < 30 and > 30
years, age factor was observed to be a potentially
negative predictive factor directly correlated
with tumor size, histopathological grade
and stage, treatment responses to intravesical
therapy and tumor recurrence.

References

  • 1. Howlader N, Noone AM, Krapcho M. SEER Cancer Statistics Review, Bladder Section, 1975–2008. Bethesda, MD: National Cancer Institute.
  • 2. Fine SW, Humphrey PA, Dehner LP, Amin MB, Epstein JI. Urothelial neoplasms in patients 20 years or younger: a clinicopathological analysis using the World Health Organization 2004 Bladder Consensus Classification. J Uro. 2005; 174:1976–80.
  • 3. Migaldi M, Rossi G, Maiorana G, Sartori G, Ferrari P, De Gaetani C, et al. Superficial papillary urothelial carcinomas in young and elderly patients: a comparative study. BJU Int 2004; 94:311–6.
  • 4. Yossepowitch O, Dalbagni G. Transitional cell carcinoma of the bladder in young adults: presentation, natural history and outcome. J Urol 2002; 168:61–6.
  • 5. Telli O, Sarici H, Ozgur BC, Doluoglu OG, Sunay MM, Bozkurt S, et al. Urothelial cancer of bladder in young versus older adults: clinical and pathological characteristics and outcomes. Kaohsiung J Med Sci 2014; 30:466-70.
  • 6. Wen YC, Kuo JY, Chen KK, Lin AT, Chang YH, Hsu YS, et al. Urothelial carcinoma of the urinary bladder in young adults- Clinical experience at Taipei Veterans General Hospital. Journal of the Chinese Medical Association 2005;68:272-5.
  • 7. Owen HC, Giedl J, Wild PJ, Fine SW, Humphrey PA, Dehner LP, et al. Low frequency of epigenetic events in urothelial tumors in young patients. J Urol 2010; 184:459–46.
  • 8. Greenfield SP, Williot P, Kaplan D. Gross hematuria in children: a ten year review. Urology 2007; 69:166–9.
  • 9. Mueller CM, Caporaso N, Greene MH. Familial and genetic risk of transitional cell carcinoma of the urinary tract. Urol Oncol 2008; 26:451–64.
  • 10. Williamson SR, Wang M, Montironi R, Eble JN, Lopez- Beltran A, Zhang S, et al. Molecular characteristics of urothelial neoplasms in children and young adults: a subset of tumors from young patients harbors chromosomal abnormalities but not FGFR3 or TP53 gene mutations. Mod Pathol 2014; 27:1540-8.
  • 11. Paner GP, Zehnder P, Amin AM, Husain AN, Desai MM. Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients: a comprehensive review of literature with implications for patient management. Adv Anat Patho. 2011; 18:79-89.
  • 12. Lezama–del Valle P, Jerkins GR, Rao BN, Santana VM, Fuller C, Merchant TE. Aggressive bladder carcinoma in a child. Pediatr Blood Cancer 2004; 43:285–8.
  • 13. Scott AA, Stanley W, Worsham GF, Kirkland TA Jr, Gansler T, Garvin AJ. Aggressive bladder carcinoma in an adolescent. Report of a case with immunohistochemical, cytogenetic, and flow cytometric characterization. Am J Surg Pathol 1989; 13:1057–63.
There are 13 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Research Article
Authors

Fatih Uruç This is me

Serkan Akan This is me

Bekir Aras This is me

Özgür Haki Yüksel This is me

Aytaç Şahin This is me

Ayhan Verit This is me

Publication Date June 1, 2018
Published in Issue Year 2018 Volume: 13 Issue: 2

Cite

Vancouver Uruç F, Akan S, Aras B, Yüksel ÖH, Şahin A, Verit A. Our mid-term follow-up results in bladder tumors below 40 years of age. New J Urol. 2018;13(2):20-5.