Urothelial neoplasms of urothelial bladder in adolescent and young adult patients

Year 2017, Volume: 12 Issue: 3, 21 - 25, 01.10.2017

Hacı Polat Murat T. Gülpınar Gül Türkçü Süleyman Çakmakçı

Abstract

Objectives: Bladder tumors are rare in adolescent and young adult patients. To date, urothelial carcinomas have usually been the only
tumors investigated in these age groups. In this
study, we aimed to describe the diagnosis, treatment, and prognosis of all urothelial bladder
tumors in adolescent and young adult patients.
Materials and Methods: This was a retrospective multicenter study involving patients
who were treated between 2008 and 2014.
Forty-two patients aged less than 40 years were
enrolled in the study. Bladder tumors were diagnosed using ultrasonography and cystoscopy,
and treated through transurethral resection of
the bladder (TURBT).
Results: The mean age of the patients was
24.21 ±10.137 years (range, 12-40 years). Thirty
(71.4%) of the 42 patients were admitted with
gross hematuria. The pathology of all patients
was reported as follows: 5 with uncommon benign lesions, 5 with papilloma, 6 with papillary
urothelial neoplasm of low malignant potential
(PUNLMP), 21 with low-grade urothelial carcinoma, and 5 with high-grade urothelial carcinoma. Two patients had muscle invasive
bladder cancer (pT2). Relapse was observed in
5 (11.9%) patients during regular cystoscopic
follow-up.
Conclusion: Approximately 40% of the
bladder tumors in adolescent and young adult
patients were not urothelial carcinomas. The
majority of these tumors were benign tumors
but relapse was not less frequent in these tumors. We suggest that urothelial benign tumors
and urothelial carcinomas of the bladder should
be closely monitored in adolescent and young
adult patients.

Keywords

benign neoplasms , cancer , adolescent , disease management , follow-up

Adolesan ve genç erişkinlerdeki ürotelyal mesane neoplazmları

Abstract

Amaç: Mesane tümörleri adolesan ve genç
erişkinlerde nadir görülür. Literatürdeki çalışmalarda, genellikle bu yaş gruplarında sadece
ürotelyal karsinomlar araştırılmıştır. Biz bu çalışmada, adolesan ve genç erişkinlerde görülen
bütün ürotelyal mesane tümörlerini, tanı, tedavi
ve prognoz açısından araştırmayı amaçladık.
Hastalar ve Metod: Çok merkezli bu retrospektif çalışmada, 2008 ile 2014 yılları arasında tedavi edilen hastalar incelendi. Kırk yaş
altındaki 42 hasta çalışmaya alındı. Mesane
tümörleri ultrasonografi ve sistoskopi ile tanımlandı ve transüretral mesane rezeksiyonu
(TUR-M) ile tedavi edildi.
Bulgular: Hastaların ortalama yaşı 24.21
±10.137 (12-24) idi. Otuz iki (%71,4) hasta
makroskopik hematüri ile başvurdu. Hastaların
patolojik spesmenleri şu şekilde raporlandı; 5
hastda nadir benign lezyon, 5 hastada papillom,
6 hastada düşük malignite potansiyelli ürotelyal neoplazm, 21 hastada düşük grade ürotelyal
karsinom ve 5 hastada yüksek grade ürotelyal
karsinom. İki hastada kas invaziv mesane kanseri vardı (pT2). Düzenli sistoskopik takipler
sırasında 5 (%11,9) hastada tümör nüksü meydana geldi.
Sonuç: Adolesan ve genç erişkinlerdeki
mesane tümörlerinin yaklaşık %40’ı ürotelyal
karsinom dışı tümörlerdir. Bu tümörlerin çoğu
benign karakterde olmasına rağmen nüks etme
potansiyelleri az değildir. Adolesan ve genç erişkinlerde, ürotelyal karsinomlarda olduğu gibi
karsinom dışı tümörlerin de yakından takip
edilmesi gerektiğini düşünüyoruz.

Keywords

benign tümörler , adolesan , hastalık yönetimi , mesane kanseri

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