Prostat spesifik antijen değeri ≤ 20 ng/ml olan prostat adenokarsinomlu olgularda kemik metastazının değerlendirilmesinde gleason skorunun önemi

Year 2011, Volume: 6 Issue: 3, 11 - 15, 01.08.2011

Ertuğrul Şefik Yusuf Kürşad Özdamar Kutan Özer

Abstract

Amaç: Bu çalışmada prostat spesifik antijen PSA değeri ≤ 20 ng/ml olan prostat kanserli olgularda kemik metastazın değerlendirilmesinde gleason skorunun önemini araştırdık.Gereç ve Yöntem: Kliniğimizde PSA yüksekliği ve anormal rektal muayene bulgusu nedeniyle transrektal ultrasografi eşliğinde 10 kadran prostat biyopsisi alınıp prostat adenokarsinomu tanısı alan, PSA değeri ≤ 20 olan olgular, gleason skoru ≤6 30 hasta ve >6 50 hasta olmak üzere iki gruba ayrıldı. Her iki grup yaş, total PSA değeri ve kemik sintigrafindeki metastaz açısından karşılaştırıldı.Bulgular: Gleason skoru ≤6 olan grupta yaş ortalaması 69.60 ± 6.56 iken gleason skoru >6 olan grupta yaş ortalaması 70.68 ± 8.34 idi p=0.153 . Gleason skoru ≤6 olan grupta ortalama PSA değeri 12.10 ± 4.57 mg/dl iken gleason skoru >6 olan grupta ortalama PSA değeri 13.11 ± 4.53 idi p=0.652 . Tüm olgularda sintigrafide kemik metastazı saptanma oranı % 31.25 iken bu oran gleason skoru ≤6 olan grupta % 6.6, gleason skoru > 6 olan grupta ise % 46.6 idi. p6 olan grupta metastaz saptanma oranının anlamlı olarak yüksek olduğu saptandı p 6 olan grupta kemik sintigrafisinde metastaz saptanma oranının anlamlı olarak yüksek olduğunu gözledik. PSA değeri 20 ng/ml’den küçük olsa bile gleason skoru > 6 olan olgularda metastaz taraması amaçlı kemik sintigrafi yapılmasını önermekteyiz

Keywords

Prostat kanseri , Gleason skoru , Prostat spesifik antijen , Kemik sintigrafisi

The importance of gleason score in the evaluation of bone metastasis in prostate adenocarcinoma patients whose prostate specific antigen level ≤ 20 ng / ml

Abstract

Objective: In this study, we investigated the importance of gleason score in detecting bone metastasis in prostate adenocarcinoma patients whose prostate-specific antigen PSA level ≤ 20 ng / ml Materials and Methods: Prostate adenocarcinoma cases diagosed by 10-quadrant transrectal ultrasound-guided prostate biopsy were divided into 2 groups of total gleason score ≤6 30 patients and total gleason score >6 50 patients . Both groups compared in terms of age, total PSA and metastasis on bone scintigraphy.Results: The mean age was 69.60 ± 6.56 in patients with gleason score ≤6 and 70.68 ± 8.34 in patients with gleason score > 6 p=0.153 . The mean PSA level was 12.10 ± 4.57 mg/ dl in patients with gleason score ≤ 6 and 13.11 ± 4.53 in patients with gleason score >6 p=0.652 . There was no singnificant difference in terms of age and total PSA however metastasis on bone scintigraphy was significantly higher in the patient with gleason score>6 p6 and PSA level ≤ 20 ng/ml. We suggest bone scintigraphy in prostate cancer patients with gleason score > 6 for metastatic evaluation even if PSA level is less than or equal to 20 ng/ml

Keywords

Prostate cancer , Gleason score , Prostate spesific antigen , Bone scintigraphy

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