Benign prostat hiperplazisi ve erektil disfonksiyon tedavisinde fosfodiesteraz tip 5 en- zim inhibitörlerinin rolü var mıdır?

Year 2014, Volume: 9 Issue: 1, 79 - 84, 01.01.2014

Yılmaz Aslan Özer Güzel Altuğ Tuncel Ali Atan

Abstract

Erektil disfonksiyon ED , tatmin edici cinsel performans için gerekli ereksiyonu sağlama ve sürdürmedeki yetersizliğin süreklilik kazanması hali olarak tanımlanır. Benign prostat hiperplazisi BPH ve ED sıklıkla ileri yaşta görülmekte ve ortak fizyopatolojiyi paylaşmaktadırlar. Her iki durum hastanın yaşam kalitesini olumsuz etkileyen önemli sağlık problemleridir. ED tedavisinde fosfodiesteraz tip 5 enzim inhibitörleri PDE5i , BPH’da alfa bloker tedaviler birinci basamak tedavi olarak kullanılmaktadır. Son yıllarda BPH’ya bağlı alt üriner sistem semptomlarının AÜSS tedavisinde PDE5i’lerin kullanımı gündeme gelmiştir. PDE5i’ler hem erektil fonksiyonları hem de AÜSS iyileştirerek BPH’da monoterapi olmaya adaydır. Bu derlemede BPH’ya bağlı AÜSS olan hastalarda PDE5i’lerin kullanımındaki güncel durum tartışılmaktadır

Keywords

Benign prostat hiperplazisi , erektil disfonksiyon , fosfodiesteraz tip 5 enzim inhibitörleri , prostat

Is there a role of phosphodiesterase type 5 enzyme ınhibitors in the treatment of benign prostatic hyperp- lasia and erectile dysfunction?

Abstract

Erectile dysfunction ED is defined as persistent inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. Benign prostatic hyperplasia BPH is often seen at advanced age like ED, and they share a common pathophysiologic mechanism. Both are major health problems that negatively affect the patients’ quality of life. As the first-line treatment, phosphodiesterase type 5 inhibitors PDE5i are used for ED, and alpha-blockers for BPH. The using of PDE5i in the treatment of lower urinary tract symptoms LUTS due to BPH, has been gaining popularity in recent years. Having therapeutic effects for both erectile function and LUTS, PDE5i are good candidates as a monotherapy in BPH patients. In this review, the current status of PDE5i therapy for patients with LUTS due to BPH is discussed

Keywords

Benign prostatic hyperplasia , erectile dysfunction , phosphodiesterase type 5 enzym inhibitors , prostate

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