The association between the lymphovascular invasion in the transurethral resection pathology and recurrence, progression, and metastasis of the disease in patients with t1 bladder cancer

Year 2018, Volume: 13 Issue: 3, 10 - 15, 01.10.2018

Fatih Yanaral Feridun Şengör

Abstract

Objective: Our study aimed to assess the relationship between lymphovascular invasion (LVI)
on transurethral resection of bladder carcinoma
(TURB) pathology and disease progression, recurrence and development of metastasis in patients
with T1 bladder cancers.

Material and Methods: The clinical records
of patients having undergone TURB in our clinic
were retrospectively reviewed. Newly diagnosed
pT1 patients with urothelial bladder cancer were
included in the study. Of the patients; sex, age,
initial diagnosis or recurrence, tumor size, tumor
number, grade, presence of Cis, presence of intravesical treatment, follow up times, recurrence,
progression, metastasis and lymphovascular invasion were recorded. Patients were divided into two
groups according to LVI status and compared in
terms of recurrence, progression and metastasis.

Results: Ninety three patients with pT1 urothelial bladder cancer were enrolled. The mean age
of the patients was 63.96 ± 9.94 (36-84). The mean
tumor size was 4.29 ± 2.54 cm (1-10 cm) and the
mean number of tumors was 2.46 ± 1.48 (1-5). LVI
was detected in 27 patients (29%). Of the 51 patients with recurrence, 18 had LVI and 33 had no
LVI (p> 0.05). Of the 22 patients with progression,
14hadLVIand8hadnoLVI(p<0.01).Ofthe15
patients with metastasis, 11 had LVI and 4 had no
LVI (p <0.01).

Conclusion: In the patients with T1 bladder
cancer, LVI after TURB is associated with the progression and metastasis of disease. Therefore, it is
a prognostic factor that can be used when planning the follow-up and treatment of the disease.
When planning the treatment of patients with superficial bladder tumors with LVI, we think that
they should be more careful and aggressive than
non-LVI patients. 

Keywords

ladder cancer , Lymphovascular invasion , Prognosis , Transurethral resection of bladder tumor

T1 mesane kanserli hastalarda, transüretral rezeksiyon spesimenindeki lenfovasküler invazyonun hastalığın rekürrens, progresyon ve metastazı ile ilişkisi

Abstract

Amaç: Bu çalışmanın amacı, yeni tanı almış
T1 mesane kanserli hastalarda transüretral me-
sane tümörü rezeksiyonu (TURMT) spesimenindeki lenfovasküler invazyonun (LVİ) hastalığın
rekürrens, progresyon ve metastazı ile olan ilişkisini araştırmaktır.

Gereç ve Yöntem: Kliniğimizde TURMT
yapılan hastaların kayıtları retrospektif olarak
incelendi ve yeni tanı almış pT1 ürotelyal mesane
kanserli hastalar çalışmaya dahil edildi. Hastaların; cinsiyet, yaş, ilk tanı veya nüks olduğu, tümör
boyutu, tümör sayısı, grade’i, Cis varlığı, intravezikal tedavi alıp almadığı, takip süreleri, rekürrens, progresyon, metastaz bilgileri ve lenfovasküler invazyon bilgileri kayıt edildi. Hastalar, LVİ
durumuna göre iki gruba ayırıldı ve rekürrens,
progresyon ve metastaz açısından karşılaştırıldı.

Bulgular: Çalışmaya toplam 93 hasta dahil
edildi. Hastaların yaş ortalaması 63.96 ± 9.94
idi (36-84). Ortalama tümör boyutu 4.29 ± 2.54
cm (1-10 cm), ortalama tümör sayısı 2.46 ± 1.48
(1-5) idi. 27 hastada (%29) LVİ saptanmıştır. Rekürrens gözlenen 51 hastanın 18’inde LVİ vardı,
33’ünde LVİ yoktu (p >0.05). Progresyon gözlenen 22 hastanın 14’ünde LVİ vardı, 8’inde LVİ
yoktu (p <0.01). Metastaz gözlenen 15 hastanın
11’inde LVİ vardı, 4’ünde LVİ yoktu (p <0.01).

Sonuç: T1 mesane kanserli hastalarda
TURMT spesimenindeki LVİ varlığı hastalığın
progresyon ve metastazı ile ilişkilidir. Dolayısıyla
hastalığın takip ve tedavisini planlarken kullanılabilecek prognostik bir faktördür. LVİ olan yüzeyel mesane tümörlü hastalarda tedaviyi planlar-
ken LVİ olmayan hastalara göre daha dikkatli ve
agresif olunması gerektiğini düşünmekteyiz. 

Keywords

Lenfovasküler invazyon , Mesane kanseri , Prognoz , Transüretral mesane tümörü rezeksiyonu

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