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Küçük hücreli prostat karsinomu: Olgu sunumu

Year 2015, Volume: 10 Issue: 2, 52 - 54, 01.05.2015

Abstract

Nöroendokrin hücreler prostat dokusunda bol olarak bulunur ve doğumda prostat içerisinde yaygın dağılım gösterirler. Bu olgu sunumundaki 63 yaşındaki hasta tarafımıza başvurduğunda yapılan incelemelerde 6 aydır alt üriner sistem semptomları AÜSS mevcuttu ve 2 aydır alfabloker tedavisi alıyordu. Prostat spesifik antijen PSA değeri 3 ng/ml olarak ölçüldü. AÜSS nedeniyle incelenen hastaya Ocak 2013’te TUR-P operasyonu yapıldı. Patoloji sonucu Küçük hücreli asiner karsinom olarak rapor edildi. Daha sonra hastaya tek ajan karboplatin AUC 5 kemoterapisi ve palyatif radyoterapi planlandı. Hasta tolere edemediği için birinci kürden sonra kemoterapi kesildi ve hasta tanının dördüncü ayında kaybedildi

References

  • Epstein JI, Walsh P, Retik AB, Vaughan ED. Pathology of prostatic neoplasia. Campbell’s Urology. Philadelphia; El- sewier 2007. p. 2880.
  • Abbas F, Civantos F, Benedetto P, Soloway M. Small cell car- cinoma of the bladder and prostate. Urology 1995;46:617- 30.
  • Burchardt T, Burchardt M, Chen MW et al. Transdifferen- tiation of prostat cancer cells to a neoroendocrine cell phe- notype in vitro and in vivo. J Urol 1999;162:1800-5.
  • Di Sant’Agnese PA. Neuoroendocrine differentiation in human prostatic carcinoma. Hum Patol 1992. p. 287-96.
  • Wu JT, Astill ME, Liu GH, Stephenson RA. Serum chro- mogranin A: Early detection of hormonal resistance in prostate cancer patients. J Clin Lab Anal 1998;12:20-5.
  • Diaz M, Abdul M, Hoosein N. Modulation of neuroen- docrine differentiation in prostate cancer by interleukin-1 and-2. Prostate Suppl 1998;8:32-6.
  • Papandreou CN, Daliani DD, Thall PF et al. Results of a phase II study with doxorubicin, etoposide, and cisplatin in patients with fully characterized small-cell carcinoma of the prostate. J Clin Oncol 2002;20:3072-80.
  • Katou M, Soga N, Onishi T, Arima K, Sugimura Y. Small cell carcinoma of the prostate treated with amrubicin. Int J Clin Oncol 2008;13:169-72.
  • Oesterling JE, Hauzeur CG, Farrow GM. Small cell anap- lastic carcinoma of the prostate: a clinical, pathologi- cal and immunohistological study of 27 patients. J Urol 1992;147:804-7.
  • Sella A, Konichezky M, Flex D, Sulkes A, Baniel J. Low PSA metastatic androgen independent prostate cancer. Eur Urol 2000;38:255-8.
  • Têtu B, Ro JY, Ayala AG et al. Small cell carcinoma of the prostate. Part I. A clinicopathologic study of 20 cases. Can- cer 1987;59:1803-9.
  • Shamelian SO, Nortier JW. Extrapulmonary small-cell car- cinoma: report of three cases and update of therapy and prognosis. Neth J Med 2000;56:51-5.
  • Benchekroun A, Nouini Y, Zannoud M et al. Small cell carcinoma of the prostate: a case report. Ann Urol 2002;36:314-7.
  • Anker CJ, Dechet C, Isaac JC, Akerley W, Shrieve DC. Small-cell carcinoma of the prostate. J Clin Oncol 2008;26:1168-71.
  • Asmis TR, Reaume MN, Dahrouge S, Malone S. Genitou- rinary small cell carcinoma: a retrospective review of treat- ment and survival patterns at The Ottawa Hospital Regio- nal Cancer Center. BJU Int 2006;97:711-5.
  • Uemura Kİ, Nakagawa G, Chikui K et al. A useful treat- ment for patients with advanced mixed-type small cell neuroendocrine carcinoma of the prostate: A case report. Oncol Lett 2013;5:793-6.
  • Wang J., Wang FW. Impact of age on clinical presentati- on, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate. Clin Interv Aging 2013;8:871-7.

Small cell prostate carsinoma: A case report

Year 2015, Volume: 10 Issue: 2, 52 - 54, 01.05.2015

Abstract

There are plenty of neuroendocrine cells in the prostatic tissue and these are widely distributed to prostate. In this case report a 63 years old patient had lower urinary tract symptoms for 6 months. He was using alpha blocker treatment for 2 months. His prostate specific antigen PSA value was 3ng/ml. TUR-P operation was performed at January 2013. Pathology result is reported as small cell carcinoma of prostate. After diagnosis, single agent carboplatin AUC 5 chemotherapy and palliative radiotherapy were planned. Chemotherapy was stopped after first cure because of intolerance of patient. He is deceased at fourth month of diagnosis

References

  • Epstein JI, Walsh P, Retik AB, Vaughan ED. Pathology of prostatic neoplasia. Campbell’s Urology. Philadelphia; El- sewier 2007. p. 2880.
  • Abbas F, Civantos F, Benedetto P, Soloway M. Small cell car- cinoma of the bladder and prostate. Urology 1995;46:617- 30.
  • Burchardt T, Burchardt M, Chen MW et al. Transdifferen- tiation of prostat cancer cells to a neoroendocrine cell phe- notype in vitro and in vivo. J Urol 1999;162:1800-5.
  • Di Sant’Agnese PA. Neuoroendocrine differentiation in human prostatic carcinoma. Hum Patol 1992. p. 287-96.
  • Wu JT, Astill ME, Liu GH, Stephenson RA. Serum chro- mogranin A: Early detection of hormonal resistance in prostate cancer patients. J Clin Lab Anal 1998;12:20-5.
  • Diaz M, Abdul M, Hoosein N. Modulation of neuroen- docrine differentiation in prostate cancer by interleukin-1 and-2. Prostate Suppl 1998;8:32-6.
  • Papandreou CN, Daliani DD, Thall PF et al. Results of a phase II study with doxorubicin, etoposide, and cisplatin in patients with fully characterized small-cell carcinoma of the prostate. J Clin Oncol 2002;20:3072-80.
  • Katou M, Soga N, Onishi T, Arima K, Sugimura Y. Small cell carcinoma of the prostate treated with amrubicin. Int J Clin Oncol 2008;13:169-72.
  • Oesterling JE, Hauzeur CG, Farrow GM. Small cell anap- lastic carcinoma of the prostate: a clinical, pathologi- cal and immunohistological study of 27 patients. J Urol 1992;147:804-7.
  • Sella A, Konichezky M, Flex D, Sulkes A, Baniel J. Low PSA metastatic androgen independent prostate cancer. Eur Urol 2000;38:255-8.
  • Têtu B, Ro JY, Ayala AG et al. Small cell carcinoma of the prostate. Part I. A clinicopathologic study of 20 cases. Can- cer 1987;59:1803-9.
  • Shamelian SO, Nortier JW. Extrapulmonary small-cell car- cinoma: report of three cases and update of therapy and prognosis. Neth J Med 2000;56:51-5.
  • Benchekroun A, Nouini Y, Zannoud M et al. Small cell carcinoma of the prostate: a case report. Ann Urol 2002;36:314-7.
  • Anker CJ, Dechet C, Isaac JC, Akerley W, Shrieve DC. Small-cell carcinoma of the prostate. J Clin Oncol 2008;26:1168-71.
  • Asmis TR, Reaume MN, Dahrouge S, Malone S. Genitou- rinary small cell carcinoma: a retrospective review of treat- ment and survival patterns at The Ottawa Hospital Regio- nal Cancer Center. BJU Int 2006;97:711-5.
  • Uemura Kİ, Nakagawa G, Chikui K et al. A useful treat- ment for patients with advanced mixed-type small cell neuroendocrine carcinoma of the prostate: A case report. Oncol Lett 2013;5:793-6.
  • Wang J., Wang FW. Impact of age on clinical presentati- on, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate. Clin Interv Aging 2013;8:871-7.
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

B Doğukan Törer This is me

Doğukan Sökmen This is me

Taner Kargı This is me

İsmail Yiğitbaşı This is me

Volkan Tuğcu This is me

Abdullah Hızır Yavuzsan This is me

Publication Date May 1, 2015
Published in Issue Year 2015 Volume: 10 Issue: 2

Cite

Vancouver Törer BD, Sökmen D, Kargı T, Yiğitbaşı İ, Tuğcu V, Yavuzsan AH. Küçük hücreli prostat karsinomu: Olgu sunumu. New J Urol. 2015;10(2):52-4.