Case Report
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Mesane Paragangliomu: Olgu sunumu

Year 2023, Volume: 18 Issue: 3, 258 - 263, 25.10.2023
https://doi.org/10.33719/yud.2023;18-3-1287231

Abstract

Mesane lezyonlarının büyük çoğunluğu, papiller ve/veya düz görünümlü ürotelyal neoplazilerdir. Ürotelyal tümör dışındaki neoplaziler oldukça nadirdir. Paragangliomalar, sempatik gangliyon veya kromafin hücre kaynaklı katekolamin salınımı yapan nadir görülen tümörlerdir. Paragangliomaların yaklaşık %10'u adrenal dışı bölgede görülür, bunun %10'u mesande izlenir ve tüm mesane tümörlerinin %0.05'ini oluşturur.
42 yaşında kadın olguda mesane sol anterolateralinde lümene protrüde 50x43 mm boyutlarında santrali nekrotik, periferinde vaskülarite artışı olan solid kitle görüldü. Dış merkez ve hastanemizde yapılan TUR materyeline ait örnekler patolojide incelendi ve paraganglioma tanısı aldı. Nadir görülmesi ve ürotelyal karsinom ile karışabilmesi nedeniyle mesanede tümörlerinde paraganglioma her zaman akılda tutulmalıdır.

References

  • 1. Urinary and Male Genital Tumours,WHO Classification of Tumours, 5th Edition. Volume 8. 202
  • 2. Menon, S., et al., Paraganglioma of the urinary bladder: a clinicopathologic spectrum of a series of 14 cases emphasizing diagnostic dilemmas. Indian J Pathol Microbiol. 2014;57(1): p.19-23. https://doi.org/10.4103/0377-4929.130873
  • 3. Erickson, D., et al., Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab. 2001;86(11):p.5210-6. https://doi.org/10.1210/jcem.86.11.8034
  • 4. Patel, S., et al., Management and evaluation of bladder paragangliomas. Asian J Urol. 2022;9(1):p.94-96. https://doi.org/10.1016/j.ajur.2021.05.012
  • 5. Lazareth, H., et al., Paraganglioma of the bladder in a kidney transplant recipient: A case report. Mol Clin Oncol. 2017;6(4): p.553-555. https://doi.org/10.3892/mco.2017.1182
  • 6. Shi, Y., et al., Bladder paraganglioma, gastrointestinal stromal tumor, and SDHB germline mutation in a patient with Carney-Stratakis syndrome: A case report and literature review. Front Oncol. 2022;12:p.1030092. https://doi.org/10.3389/fonc.2022.1030092
  • 7. Zhou, M., J.I. Epstein, and R.H. Young, Paraganglioma of the urinary bladder: a lesion that may be misdiagnosed as urothelial carcinoma in transurethral resection specimens. Am J Surg Pathol. 2004;28(1):p.94-100. https://doi.org/10.1097/00000478-200401000-00011
  • 8. Amin, M.B., Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications. Modern Pathology. 2009;22(2):p.S96-S118. https://doi.org/10.1038/modpathol.2009.26
  • 9. Saha, A., et al., Paraganglioma of Urinary Bladder: An Uncommon Entity in Uropathology. Cureus. 2021;13(8):p.e17265. https://doi.org/10.7759/cureus.17265
  • 10. Grivas, N., et al., Follicular thyroid cancer metastasis to the urinary bladder: report of a case and review of the literature. Case Rep Urol. 2012.2012:p.178915. https://doi.org/10.1155/2012/178915

Paraganglioma of Urinary Bladder: A Case Report

Year 2023, Volume: 18 Issue: 3, 258 - 263, 25.10.2023
https://doi.org/10.33719/yud.2023;18-3-1287231

Abstract

The majority of bladder lesions are papillary and/or flat-appearing urothelial neoplasms. Neoplasms besides urothelial tumors are very rare. Paragangliomas are rare catecholamine-releasing tumors of sympathetic ganglion or chromaffin cell origin. Approximately 10% of paragangliomas occur in the non-adrenal region, of which 10% are seen in the bladder and constitute 0.05% of all bladder tumors.
In a 42-year-old female patient, a 50x43 mm solid mass protruding into the lumen on the left anterolateral aspect of the bladder was observed with necrotic center and increased vascularity on the periphery. The specimens of the TUR material obtained from an external center and our hospital were examined by pathology and diagnosed as paraganglioma. Because of its rarity and confusion with urothelial carcinoma, paraganglioma should always be kept in mind when dealing with bladder tumors.

References

  • 1. Urinary and Male Genital Tumours,WHO Classification of Tumours, 5th Edition. Volume 8. 202
  • 2. Menon, S., et al., Paraganglioma of the urinary bladder: a clinicopathologic spectrum of a series of 14 cases emphasizing diagnostic dilemmas. Indian J Pathol Microbiol. 2014;57(1): p.19-23. https://doi.org/10.4103/0377-4929.130873
  • 3. Erickson, D., et al., Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab. 2001;86(11):p.5210-6. https://doi.org/10.1210/jcem.86.11.8034
  • 4. Patel, S., et al., Management and evaluation of bladder paragangliomas. Asian J Urol. 2022;9(1):p.94-96. https://doi.org/10.1016/j.ajur.2021.05.012
  • 5. Lazareth, H., et al., Paraganglioma of the bladder in a kidney transplant recipient: A case report. Mol Clin Oncol. 2017;6(4): p.553-555. https://doi.org/10.3892/mco.2017.1182
  • 6. Shi, Y., et al., Bladder paraganglioma, gastrointestinal stromal tumor, and SDHB germline mutation in a patient with Carney-Stratakis syndrome: A case report and literature review. Front Oncol. 2022;12:p.1030092. https://doi.org/10.3389/fonc.2022.1030092
  • 7. Zhou, M., J.I. Epstein, and R.H. Young, Paraganglioma of the urinary bladder: a lesion that may be misdiagnosed as urothelial carcinoma in transurethral resection specimens. Am J Surg Pathol. 2004;28(1):p.94-100. https://doi.org/10.1097/00000478-200401000-00011
  • 8. Amin, M.B., Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications. Modern Pathology. 2009;22(2):p.S96-S118. https://doi.org/10.1038/modpathol.2009.26
  • 9. Saha, A., et al., Paraganglioma of Urinary Bladder: An Uncommon Entity in Uropathology. Cureus. 2021;13(8):p.e17265. https://doi.org/10.7759/cureus.17265
  • 10. Grivas, N., et al., Follicular thyroid cancer metastasis to the urinary bladder: report of a case and review of the literature. Case Rep Urol. 2012.2012:p.178915. https://doi.org/10.1155/2012/178915
There are 10 citations in total.

Details

Primary Language English
Subjects Urology
Journal Section Case Report
Authors

Tuğçem Bıçak 0000-0002-3160-8321

Selver Özşener Özekinci 0000-0002-0645-8755

Yekta Bıçak This is me 0000-0003-0022-0145

Mansur Dağgülli 0000-0002-7855-0032

Publication Date October 25, 2023
Published in Issue Year 2023 Volume: 18 Issue: 3

Cite

Vancouver Bıçak T, Özşener Özekinci S, Bıçak Y, Dağgülli M. Paraganglioma of Urinary Bladder: A Case Report. New J Urol. 2023;18(3):258-63.