Bazı Florokinolon Antibiyotiklerle Santral Sinir Sistemi İlaçlarının Farmakolojik Etkileşim Özellikleri Üzerine Deneysel Araştırmalar

Year 1998, Volume: 4 Issue: 1-2, 52 - 64, 14.06.1998

Hanefi Özbek Orhan Yılmaz

Abstract

Bu çalışmada, sağaltımda yaygın olarak kullanılan ve santral sinir sistemiyle ilgili istenmeyen etkileri bildirilen florokinolon grubu antibiyotiklerden siprofloksasin, ofloksasin, pefloksasin ve norfloksasinin santral sinir sistemini etkileyen ilaçlarla birlikte kullanıldığında oluşabilecek etkileşimler ve bu etkileşimlerin ne yönde gelişebileceğinin belirlenmesi amaçlanmıştır. Siprofloksasin, ofloksasin, pefloksasin ve norfloksasinin santral sinir sistemi uyarıcısı olan teofllin ve bir genel anestezik olan etomidatla oluşabilecek etkileşimini belirlemek için motor aktivite testleri, öpen field testi, yüzme testi ve uyku süresinin hesaplanması gerçekleştirildi. Çalışmada inbred yetiştirilmiş ortalama 20-30 gram ağırlıkta toplam 160 adet Mus musculus Swiss-albino fare kullanıldı. Her biri beş erkek ve beş dişi olmak üzere 10'ar fareden oluşturulan 16 deneme grubunda çalışıldı. Çalışmada siprofloksasinin motor aktivite testlerinin sonucuna göre teofilinin etkisini önemli derecede artırdığı p

Keywords

Florokinolon antibiyotikler, Etomidat, Teofllin, Farmakolojik etkileşim

Experinıental Stuclies on the Plıarmacologic interaction of Some Fluoroquiııolone Antibiotics with Central Nervous System Drugs

Abstract

This study aims to investigate the interaction of antimicrobial drugs such as ciprofloxacin, ofloxacin, pefloxacin and norfloxacin with drugs affecting Central ııeural system. İn order to determine the interaction of ciprofloxacin, ofloxaciıı, pefloxacin and norfloxacin with theophylline, a Central nervous system stimulant, and with etomidate a general aııaesthetic; motor activity tests, swimming test and the measuring of sleeping time were carried out. inbred 16 Mus musculus Swiss albino mice with an average weight between 20-30 grams were ıısed. Mice were divided into 16 experiment groups, each containing ten mice, halfmale and half female. It was observed that ciprofloxacin signifıcantly iııcreased the interaction of theophylline according to the motor activity test p

Keywords

Fluoroquinolone antibiotics, Etomidate, Theophylline, Pharmacologic interaction

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