The role of lymphatic system on actioıı mechanism of early type allergic reactions

Year 2001, Volume: 7 Issue: 1-2, 32 - 36, 01.06.2001

Hakani Sabiroğlu Orhan Yılmaz Asmagül Sabiroğlu

Abstract

The examination of the roles of some biological active substances in early type allergic reactions was aimed in this study. 24 dogs were used as experimental animals. Levels of histamine, serotonin, bradykinin, kallikrein, kininogen and kininase were measured in blood and lymph samples collected at times before and after sensitization; and at times before and after 5th, 30th, 60th, 180th minutes of anaphylactic shock. İt was found that histamine and serotonine levels in the blood and lymph increased at the 5th minute of anaphylactic shock; but the maximum changes in the components of Kallikrein-Kinin System were detected at the 30th minute. The levels of biological amines in the lymph of dogs with anaphylactic shock were higher than which of in the blood. It was concluded that lymphatic system was very important for determining early type allergic reactions

Keywords

Anaphylactic shock, Serotonin, Histamine, Kallikrein-kinin.

Erken tip alerjik reaksiyonların etki mekanizmasında lenfatik sistemin rolü

Abstract

Erken tip alerjik reaksiyonlarda bazı biyolojik aktif maddelerin rolünün incelenmesinin amaçlandığı bu çalışmada, deney hayvanı olarak 24 adet köpek kullanılmıştır.Sensibilizasyondan önce ve sonra, anaflaktik şoktan önce ve sonraki 5., 30.. 60, ve 180. dakikalarda alman kan ve lenf örneklerinde histamin, serotonin, bradikinin. kallikrein, kininojen ve kininaz düzeyleri ölçülmüştür. Kan ve lenfteki histamin ve serotonin düzeyi anaflaktik şokun 5. dakikasında yükseliş göstermiş; Kallikrein-Kinin Sistemi komponentlerindeki maksimum değişiklik ise ilk 30 dakikada saptanmıştır. Köpeklerdeki anaflaktik şok durumunda biyolojik aminler, kana oranla lenfte daha yüksek bulunmuştur. Erken tip allerjik reaksiyonların saptanmasında lenfatik sistemin çok önemli olduğu sonucuna varılmıştır

Keywords

Anaflaktik şok, Serotonin, Histamin, Kallikrein-kinin

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