Köpeklerde tiletamin-zolazepam ve tiletamin-zolazepam-xylazin anestezisi

Year 2001, Volume: 7 Issue: 1-2, 103 - 109, 01.06.2001

Nihat Şındak İsmail Alkan

Abstract

Bu çalışma köpeklerde tiletamin-zolazepam ve tiletamin-zolazepam-xylazin kombinasyonlarının anestezik etkilerini araştırmak amacıyla değişik ırk, yaş, canlı ağırlık ve cinsiyette toplam 40 köpek üzerinde gerçekleştirildi. Birinci grup köpeklere n=20 tiletamin-zolazepam 10 mg/kg , 2. grup köpeklere n=20 ise tiletamin-zolazepam 10 mg/kg ve xylazin 1 mg/kg kombinasyonu im uygulandı. Anestezi öncesi, sırası ve anesteziden 24 saat sonra klinik bulgular, hematolojik parametreler ve biyokimyasal kan parametreleri ile ilgili sonuçlar belirlendi. İlaç uygulamasının hematolojik ve biyokimyasal kan parametrelerinde minimal etkiler meydana getirdiği, ayrıca iyi kas gevşemesi sağlayarak uygun anestezik koşullar oluşturduğu tespit edildi.Tiletamin-zolazepam uygulanan olgularda ortalama 5.9 dk'da indüksiyon ve 97 dk'lık şirurjikal anestezi süresi saklandı. Tiletamin-zolazepam-xylazin verilen köpeklerde ise ortalama 3.7 dk'da indüksiyon ve 101 dk süren şirurjikal anestezi süresi elde edildi. Buna göre her iki gruptaki köpeklerde tiletamin-zolazepam ve tiletamin-zolazepamxylazin kombinasyonlarının pratikte uygulanabileceği, tiletamin-zolazepam- xylazinle, tiletamin-zolazepamdan daha etkili ve daha uzun süreli anestezi sağlandığı ortaya konuldu

Keywords

Tiletamin, Zolazepam, Anestezi, Köpek

Tiletamin-zolazepam and tiletamin-zolazepam-xylazin anetsthesia in dogs

Abstract

In this study the anesthetic effect of the combinations of tiletamin-zolazepam and tiletamin-zolazepam-xylazin were investigated in 40 dogs which were in different breed, age, body weight and sex. First group of dogs n=20 were injected with the combination of tiletamin-zolazepam 10 mg/kg and second group of dogs n=20 were injected with the combination of tiletamin-zolazepam 10 mg/kg plus xylazin 1 mg/kg intramuscularly. Clinical fındings, heamatological and biochemical parameters were recorded before, during and 24 hour after anesthesia. The results showed that both combinations had an excellent effect of muscular relaxation and positive anesthetic conditions. On the other hand, both combinations had a little effect on the heamatological and biochemical parameters. Dogs that injected with tiletamin-zolazepam had a mean value of 5.9 minutes induction period and 97 minutes surgical anesthetic duration. However, dogs that injected with tiletaminzolazepam-xylazin had a mean value of 3.7 minutes induction period and 101 minutes surgical anesthesia duration. In this study; results demonstrated that the combinations of tiletamin-zolazepam or tiletamin-zolazepam-xylazin can be used in practice as anesthetics. It was also found that the combination of tiletamin- zolazepam-xylazin is more effective anesthetic than the combination of tiletamin-zolazepam

Keywords

Tiletamin, Zolazepam, Anesthesia, Dog

References

• 1. Benson GJ, Wheaton LG, Thurmon JC, Tranquilli WJ, Olson WA: Effects of Telazol-Xylazine-Butorphanoi Anesthesia for Ovariohysterectomy of Dogs. In Proceeding of The Annual Meeting of American College of Veterinary Anesthesiologists. pp. 12, New Orleans, Louisiana, (1989).
• 2. Codner EC, Lessard P, Mc Graht C: Effect of Tiletamine/Zolazepam Sedation on Intradermal Allergy Testing in Atopic Dogs. JAVMA 201 (2): 1857-1860, (1992).
• 3. Hail LW, Clarke LW: Veterinary Anaesthesia. Baillie're TindallLondon 8. Ed, (1983).
• 4. Hellyer P, Muir WW, Hııbbell JAE, Sally, J: Cardiorespiratory Effects of The lntravenous Administration of TiletamineZolazepam to Cats. Veterinary Surgery, 18: 105-110 (1988).
• 5. Shoı t CE, Tracy CH: Technical Discussion About Telazol. Vet. Med. 83:8-10, (1988).
• 6. Bree MM, Cohen BJ, Rowe SE: Dissociative Anesthesia in Dogs and Primates: Clinical Evakıation of Cl-744. Laboratory Animal Science 22: 878-881, (1972).
• 7. Chen CF, Chow SY: Effects of Tiletamine on Spinal Cord Synaptic Transmission. Eıırop J. Pharmacol. 27: 346-348 (1974).
• 8. Smith RD, Pettway CE: Absence of Sensitization to EpinephrineInduced Caıdiac Arrhythmia and Fibıillation in Dogs and Cats Anesthetized With CI-744. Am. J. Vet. Res. 36: 695-698, (1975).
• 9. Haefely W: Neııropharmacology of Benzodiazepines. Synaptic Mechanisms and Neural Basis of Action. The Benzodiazepines: From Molecular Biology to Clinical Practice. Raven Press New York N. Y. 21-66, (1983).
• 10. Heerden JV. Burroııghs REJ, Dauth J, Dreyer M J: Immobilization of Wild Dogs (Lycaon Pictus) With A Tiletamine Hydrochloride Zolazepam Hydrochloride Combination and Subsequent Evaluation of Selected Blood Chemistry Parameters. J Wild Dis 27 (2): 225-229, (1991).
• 11. Hellyer P, Muir WW, Hubbell JAE, Sally J: Cardiorespiratory Effects of The Intravenous Administration of TiletamineZolazepam to Dogs, Vet Surg 18: 160-165, (1989).
• 12. Potoczak R. Corey R: The Effects of Ci-744 Upon Cardiovascular Function In the Dog. Federal Proceedings, 34: 771,(1975).
• 13. Lin HC, Thurmon J, Benson GS, Tranquilli WJ: Telazol A Review of Its Pharmacology and Use in Veterinary Medicine. J. Vet. Pharm. Therapy. 16: 383-418, (1992).
• 14. Sanders E, Short CE, Keegan R, Tracy CH: Measuring How Dogs Respond to Telazol-Xylazine Combinations. Vet Med Feb. 222- 227, (1989).
• 15. Tracy CH, Short CE, Clark BC: Comparing the Effects of Intravenous and Intramuscular Administration of Telazol. Vet. Med. 83: 104-111, (1988).
• 16. Donaldson LL, Mcgrath CJ, Tracy CH: Testing Low Doses of (R) Intravenous Telazol in Canine Practice. Vet Med 84: 1202- 1207,(1989).
• 17. Fieni F, Tainturier D: Die Anvvendung Von Tilest® Zur Intıavenösen Anasthesie Beim Hund. Kleintierpıaxis 38 (2) 111- 114 (1993).
• 18. Vila C, Castroviejo J: Use of Tilatamine and Zolazepam to Immobilize Captive Iberian Wolves (Canis Lupus). J Wild Dis 30(1) 119-122,(1994).
• 19. Schatzmann U: Clinical Considerations of Complications of The Pulmonary System. Principles and Practice of Veterinary Anesthesia (C.E. Short., Ed) Williams and Wilkins, Baltimore, (1987).
• 20. Hsu WH, Lu JX, Hembrough. B: Effect of Xylazine on Heaıt Rate and Arteriel Blood Pressure in Conscious Dogs, As Influenced By Atropine, 4-Aminopyridine, Doxopram and Yohimbine. JAVMA. 186 (2): 153-156, (1985).
• 21. Knight AP: Xylazine. JAVMA 176: 454-455, (1980).
• 22. Lumb WV, Jones, EW: Veterinary Anesthesia 2^ Ed. Lea and Febiger, Philadelphia, (1984).
• 23. Jaksch W, Glawisching E: Klinische Propaedeutik Der Inneren Krankheinten Und How Krankheitender Haus- Und Heimtiere. 3.Aufl., Pp.109-116, Verlag Paul Parey, Berlin Und Hamburg (1990).
• 24. BreeMM, Park JS, Beck, CC, Moser JH: Effects of (R) Chloramphenicol on Tilazol , (Ci-744) Anesthesia in Dogs. Vet. Med./Smail Anim Clin 71: 1243-1246, (1976).
• 25. Short CE: Talking About Telazol: Round Table. Vet Med. 84: 1-8 (1989).