Peganum harmala L. (Üzerlik) Tohum Ekstresinin Analjezik Aktivitesi ve Akut Toksisitesinin Fareler Üzerinde Belirlenmesi
Abstract
Keywords
References
- Abdel-Fattah MAF, Matsumoto K, Gammaz HAK and Watanabe H (1995). Hypotermic effect of harmala alkaloid in rats: Invovement of seretonergic mechanism. Pharmacol Biochem Behavior, 52 (2), 421-426.
- Airaksinen MM, Saano V, Steidel E, juvonen H, Huhtikangas A, Gynther J (1984). Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta- type. Acta Pharmacol Toxicol, 55, 380-385.
- Baytop T (1984). Türkiye’de Bitkilerle Tedavi (Geçmişte ve Bugün), İÜ yayınları. İstanbul, 402.
- Budavari S, O’Nenil MJ (1996). The merk index. CRC Press, New Jersey, 12th, 4644-4645.
- D’amour FE and Smith DL (1941). A method for determining loss of pain sensation. J Pharmac Exp Ther, 72, 74-79.
- Davis PH (1967). ‘flora of Turkey and the East Aegeam Islands. Vol II, Endinburgh University Pres.
- Hunskaar S, Fasmer OB, Hole K (1985). Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods, 14 (1), 69-76.
- Kartal M, Altun ML and Kurucu S (2003). HPLC medhod for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L. J Pharmaceut Biomedical Analysis, 31, 263-69.
- Keleş O, Ak S, Bakırel T, Alpınar K (2001). Türkiye’de yetişen bazı bitkilerin antibakteriyel etkisinin incelenmesi. Turk J Vet Anim Sci, 25, 559-565.
- Koster RM, Anderson M and De Beer AJ (1959). Acetic Acid for Analgesic. Screening, Fed Proc, 18, 412.
- Mahmoudian M, Jalilpour H, Salehian P (2002). Toxicity of Peganum harmala: Review and a Case Report. IJPT, 1, 1-4.
- Matsumoto K, Horie S, Ishikawa H, Takayama H, Aimi N, Ponglux D, Watanabe K (2004). Antinociceptive effect of 7- hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa. Life Sciences, 74, 2143-2155.
- Shi CC, Liao JF, Chen CF (2001). Spasmolytic effect of three harmala alkaloids on guinea-pig isolated trachea. Pharmacol Toxicol, 89, 259-264.
- Sümbüloğlu K ve Sümbüloğlu V (1998). Biyoistatistik. Sekizinci baskı, Şahin Matbaası, Ankara.
- Surdarsky L (1990). Pathophysiology of the Nervous System. Little, Brown and Company, 88-89.
- Tanker M, Tanker N (1990). Farmakognozi Cilt 2, Ankara Üniv. Eczacılık Fak. Yayınları Ankara, 65, 148-149.
Peganum harmala L. (Üzerlik) Tohum Ekstresinin Analjezik Aktivitesi ve Akut Toksisitesinin Fareler Üzerinde Belirlenmesi
Abstract
Bu çalışmada P. harmala tohum ekstresinin medyan letal dozu (LD50) ve analjezik aktivite yönünden incelenmesi amaçlandı. Tohum ekstresinin LD50 dozu 0,178 ml/kg olarak bulundu. Analjezik aktivite deneylerinde ise, her bir gruba sırasıyla serum fizyolojik, DMSO, P. harmala tohum ekstresi, aspirin ve morfin uygulandı. Asetik asit ile ağrı oluşturma deneyinde, P. harmala tohumları 30 ve 60 mg/kg dozlarında aspirine göre anlamlı, 90 mg/kg dozunda aspirine göre çok anlamlı bir etki gösterdi. Tail Flick deneyinde, P. harmala tohumlarının 30 ve 60 mg/kg dozlarında analjezik etkisi 100 mg/kg aspirine denk bulundu ve 10 mg/kg morfine göre ise istatistiksel açıdan anlamlı bir fark bulunmadı
References
- Abdel-Fattah MAF, Matsumoto K, Gammaz HAK and Watanabe H (1995). Hypotermic effect of harmala alkaloid in rats: Invovement of seretonergic mechanism. Pharmacol Biochem Behavior, 52 (2), 421-426.
- Airaksinen MM, Saano V, Steidel E, juvonen H, Huhtikangas A, Gynther J (1984). Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta- type. Acta Pharmacol Toxicol, 55, 380-385.
- Baytop T (1984). Türkiye’de Bitkilerle Tedavi (Geçmişte ve Bugün), İÜ yayınları. İstanbul, 402.
- Budavari S, O’Nenil MJ (1996). The merk index. CRC Press, New Jersey, 12th, 4644-4645.
- D’amour FE and Smith DL (1941). A method for determining loss of pain sensation. J Pharmac Exp Ther, 72, 74-79.
- Davis PH (1967). ‘flora of Turkey and the East Aegeam Islands. Vol II, Endinburgh University Pres.
- Hunskaar S, Fasmer OB, Hole K (1985). Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods, 14 (1), 69-76.
- Kartal M, Altun ML and Kurucu S (2003). HPLC medhod for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L. J Pharmaceut Biomedical Analysis, 31, 263-69.
- Keleş O, Ak S, Bakırel T, Alpınar K (2001). Türkiye’de yetişen bazı bitkilerin antibakteriyel etkisinin incelenmesi. Turk J Vet Anim Sci, 25, 559-565.
- Koster RM, Anderson M and De Beer AJ (1959). Acetic Acid for Analgesic. Screening, Fed Proc, 18, 412.
- Mahmoudian M, Jalilpour H, Salehian P (2002). Toxicity of Peganum harmala: Review and a Case Report. IJPT, 1, 1-4.
- Matsumoto K, Horie S, Ishikawa H, Takayama H, Aimi N, Ponglux D, Watanabe K (2004). Antinociceptive effect of 7- hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa. Life Sciences, 74, 2143-2155.
- Shi CC, Liao JF, Chen CF (2001). Spasmolytic effect of three harmala alkaloids on guinea-pig isolated trachea. Pharmacol Toxicol, 89, 259-264.
- Sümbüloğlu K ve Sümbüloğlu V (1998). Biyoistatistik. Sekizinci baskı, Şahin Matbaası, Ankara.
- Surdarsky L (1990). Pathophysiology of the Nervous System. Little, Brown and Company, 88-89.
- Tanker M, Tanker N (1990). Farmakognozi Cilt 2, Ankara Üniv. Eczacılık Fak. Yayınları Ankara, 65, 148-149.
There are 16 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | March 1, 2009 |
| Published in Issue | Year 2009 Volume: 20 Issue: 1 |