Aquarium Behavioral Genetics
Abstract
The relationships between genes, environments, and the stress response, as well as their roles in the development and progression of disease, are largely unclear. Addiction, as well as mood and anxiety disorders, are behavioural diseases that can be influenced by both genetic and environmental factors. It is possible to determine the genetic or epigenetic contribution to polygenic disease with unbiased forward genetic screens. Phenotype analysis is facilitated by the quick distinction between mutant carriers and non-carriers in both larval and adult zebrafish. Visual sorting is made possible by gene-break transposon mutagenesis techniques or by selectively breeding cloned mutants to fluorescently tagged linkage groups. This crucial step enables the focus to be placed on the impact of a single gene rather than the influence of a diverse genome on complicated behavioural characteristics. Utilising mutagenesis in conjunction with trustworthy behavioural assays in both the larval and adult Zebrafish will make it possible to do genome-wide studies on the genes that affect how stress is perceived, how it spreads, and how it is attenuated. Longitudinal screens that look at the stress response as. Its evolves from larvae to adults can be used to identify genetic systems that are essential for perceiving environmental cues and epigenetic programming of the stress response.
Keywords
genes, environments, stress response, Zebrafish, transposon, mutagenesis
Thanks
to Proof.Dr. Mehmet Özaslan
to My husband Dr. Suhail Bayati
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