The Investigation of CA 15-3 Antigen Levels in Local and Immigrant Women Patients Diagnosed with Breast Cancer in Gaziantep
Abstract
Breast cancer is the most prevalent cancer type among women globally and in Turkey. CA 15-3, a mucin antigen derived from the MUC1 gene, serves as a significant biomarker in the diagnosis and monitoring of breast cancer. The aim of this study was to compare CA 15-3 antigen levels in breast cancer patients in Turkey based on variables such as age, ethnicity, and disease stage. The results revealed that CA 15-3 levels were significantly higher in women over the age of 50 compared to those under 50 (p<0.001). Additionally, it was found that Syrian women had higher CA 15-3 antigen levels than Turkish women, suggesting that Syrian patients tend to present at more advanced stages of the disease. Comparisons between the patient and control groups showed that CA 15-3 levels were significantly elevated in the breast cancer patients (p<0.001). These findings suggest that CA 15-3 antigen plays a critical role in breast cancer diagnosis, and that factors such as age and ethnicity influence the levels of this biomarker. This study aims to contribute to the literature on public health epidemiology by comparing CA 15-3 levels between Turkish and Syrian women.
Keywords
Supporting Institution
Gaziantep University Clinical Research and Ethics Committee.
Project Number
2023/186
References
- 1. TC Sağlık Bakanlığı, 2018 Ulusal Kanser Kontrol Planı. 2013; 2021.
- 2. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet‐Tieulent J, Jemal A. Global cancer statistics, 2012. CA: a cancer journal for clinicians. 2015;65(2): 87-108.
- 3. TC Sağlık Bakanlığı, Halk Sağlığı Genel Müdürlüğü, and Kanser Daire Başkanlığı. Türkiye kanser istatistikleri, Ankara 2018.
- 4. B. Başara, B. S Çağlar, İ. Aygün, A. Özdemir, T, A. Kulali ve ark. S. B. (2019). TC Sağlık Bakanlığı Sağlık İstatistikleri 2018.
- 5. Dalziel M, WhitehouseIan C, Farlane M, Clausen H, Taylor J.The Relative Activities of the C2GnT1 and ST3Gal-I Glycosyltransferases Determine O Glycan Structure and Expression of a Tumor-associated Epitope on MUC1. Journal of Biological.2001; 276.14: 11007-11015
- 6. Croce MV, Isla-Larrain MT, Price M, R. Segal, Eiras, A. Detection of circulating mammary mucin (Muc1) and MUC1 immune complexes (Muc1-CIC) in healthy women.The International journal of biological markers. 2001;16(2): 112-120.
- 7. Kozan R; Tokgöz V. Türkiye’de meme kanseri farkındalığı ve tarama programı Acıbadem Üniversitesi Sağlık Bilimleri Dergisi. 2016;7.4.
- 8. Safi, F. Kohler, I., Beger, H. G., & Röttinger, E. The value of the tumor marker CA 15‐3 in diagnosing and monitoring breast cancer. A comparative study with carcinoembryonic antigen Cancer. 1991;68(3): 574-582
- 9. Park, B-W., et al. Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes Annals of oncology. 2008; 19.4: 675-681.
- 10. Duffy M. J. Shering, S. Sherry F. McDermott E. O'higgins N. ,CA 15–3: A prognostic marker in breast cancer. The International journal of biological markers. 2000;15(4): 330-333.