EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW)

Rıdvan Lawal; Mehmet Özaslan

EN

EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW)

Abstract

Cancer is the uncontrolled growth of cells in the body. Drugs have been developed to treat cancer. These drugs act to control the growth of cells. Medicinal plants have been sources of effective drugs used in the treatment of cancer over the past few decades. Testing of medicinal plants for their cancer chemotherapeutic functions involve the use of models of cancer cells. Ehrlich ascites carcinoma cells are a common transplantable tumor that has been employed in several studies to mimic mammary tumor in animals. The tumor is able to survive and grow in animals. Several studies have shown the universality of the use of these tumor cells in testing for medicinal plants with anti-cancer properties.

Keywords

Ehrlich, Ascites, carcinoma, plants, cancer

References

Ridwan Abiodun Lawal, Mehmet Ozaslan,Rahmat Adetutu Adisa, Omolola Selina Odesanmi, Isik Didem Karagoz, Ibrahim Halil Kilic, Osaretin Albert Taiwo Ebuehi (2019) Comparative cytotoxic activity of selected Nigerian medicinal plant extracts on Ehrlich ascites carcinoma cells. LASU Journal of Health Sciences, 2(2):69-72.
Lawal RA, Odesanmi OS, Ozaslan MD, Ebuehi OAT, Karagoz ID, Kilic IH, Uyar C. Gas Chromatography-Mass Spectrometry and Cytotoxicity of Securidaca longepedunculata (polygalaceae) Root Bark Extract. Fountain University Journal of Natural and Applied Science. 2016; 5(1): 26-34.
Ramakrishna Y, Manohar AL, Mamata P, Shreekant KG (1984). Plants and novel antitumor agents: A review. Indian Drugs 21: 173-185.
Kavimani S, Manisenthil kumar KT (2000). Effect of methanol extract of Enicostemna littorale on Dalton’s lymphoma. J. Ethnopharmacol. 71: 349-352.
Lawal, R.A., Ozaslan, M.D., Odesanmi, O.S, Karagoz, I.D., Kilic, I.H. &Ebuehi, O.A.T (2012). Cytotoxic and antiproliferative activity of Securidaca longepedunculata aqueous extract on Ehrlich ascites carcinoma cells in Swiss albino mice. International Journal of Applied Research Natural Products,5(4)19-27.
Mazumder UK, Gupta M, Maiti S, Mukherjee M (1997). Antitumor activity of Hygrophila spinosa on Ehrlich ascites carcinoma and sarcoma-180 induced mice. Indian J. Exp. Biol. 35: 473-477.
Gupta M, Mazumder UK, Rath N, Mukhopadhyay DK (2000). Antitumor activity of methanolic extract of Cassia fistula L. seed against Ehrlich ascites carcinoma. J. Ethnopharmacol. 72: 151-156.
Gupta M, Mazumder UK, Sambath Kumar R, Sivakumar T, Mohan vamsi ML (2004). Antitumor Activity and Antioxidant Status of Caesalpinia bonducella Against Ehrlich Ascites Carcinoma in Swiss Albino Mice. J. Pharmacol. Sci. 94: 177-184. Salamone M.F., J.A. Heddle, E. Stuart and A. Katz (1980). Towards an improved micronucleus test: Studies on 3 model agents mitomycinc, cyclophosphamide and dimethylbenzanthracene. Mutation Research, 44: 347-356.
Burton, K. (1956). A study of the condition and mechanisms of the diphenylamine reaction for the estimation of deoxyribonucleic acid. Biochemical J., 62: 315-323.
Perandones, C.E., V.A. Illera, D. Peckham, L.L. Stunz and R.F. Ashman (1993) Regulation of apoptosis in vitro in mature murine spleen T-cells. J. Immunol., 151: 3521-3529.

Pal,S., Choudhuri,T., Chattopadhyay,S., Bhattacharya,A., Datta,G.K., Das,T. and Sa,G. (2001) Mechanisms of curcumin-induced apoptosis of Ehrlich’s ascites carcinoma cells. Biochem. Biophys. Res. Commun., 288, 658–665.
Das,T., Sa,G., Chattopadhyay,S. and Ray,P.K. (2002) Protein A-induced apoptosis of cancer cells is effected by soluble immune mediators. Cancer Immunol. Immunother., 51, 376–380.
Chattopadhyay,S, Das,T, Sa,G and Ray,P.K. (2002) Protein A-activated macrophages induce apoptosis in Ehrlich’s ascites carcinoma through a nitric oxide-dependent pathway. Apoptosis, 7, 49–57.
Choudhuri,T., Pal,S., Agwarwal,M., Das,T. and Sa,G. (2002) Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett., 512, 334–340.
Shibata,M.A., Maroulakour,I.G., Jorcyk,C.L., Gold,L.G., Ward,J.M. and Green,J.E. (1996) p53-dependent apoptosis during mammary tumor progression in C3(1)/SV40 large T antigen transgenic mice: suppression of apoptosis during the transition from preneoplasia to carcinoma. Cancer Res., 56, 2998–3003.
Das,T., Sa,G., Sinha,P. and Ray,P.K. (1999) Induction of cell proliferation and apoptosis: dependence on the dose of the inducer. Biochem. Biophys. Res. Commun., 260, 105–110.
Basu,A. and Haldar,S. (1998) The relationship between BcI2, Bax and p53: consequences for cell cycle progression and cell death. Mol. Hum. Repro., 4, 1099–1109.
Levin,A. (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323–331.
Chen,X., Bargonetti,J. and Prives,C. (1995) p53, through p21 (WAF1/ CIP1), induces cyclin D1 synthesis. Cancer Res., 55, 4257–4262.
Choi,Y.H., Choi,B.T., Lee,W.H., Rhee,S.H. and Park,K.Y. (2001) Doenjang hexane fraction-induced G1 arrest is associated with the inhibition of pRB phosphorylation and induction of Cdk inhibitor p21 in human breast carcinoma MCF-7 cells. Oncol. Rep., 8, 1091–1096.
Miyashita, T. and Reed, J. C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human Bax gene. Cell, 80, 293–299.
Miyashita, T., Krajewski, S., Krajewska, M., Wang, H. G., Lin, H. K., Liebermann, D. A., Hoffman, B. and Reed, J. C. (1994) Tumor suppressor p53 is a regulator of Bcl-2 and Bax gene expression in vitro and in vivo. Oncogene, 9, 799–1805.
da Mota MF, Benfica PL, Batista AC, Martins FS, de Paula JR, Valadares MC (2012) Investigation of Ehrlich ascites tumor cell death mechanisms induced by Synadenium umbellatum Pax. J. Ethnopharmacol. 139(2) 319– 329
G.Z. Justo, N. Duran, M.L.S. Queiroz (2000) Myelopoietic response in tumor-bearing mice by an aggregated polymer isolated from Aspergillus oryzae, Eur. J. Pharmacol. 388: 219–226.
Natália Bromberg, Juliana L Dreyfuss, Caio V Regatieri, Marcelly V Palladino, Nelson Durán, Helena B Nader, Marcela Haun, Giselle Z Justo (2010) Growth inhibition and pro-apoptotic activity of violacein in Ehrlich ascites tumor. Chemico-Biological Interactions 186(1)43–52.
Lisa Botes, Francois H. van der Westhuizen and Du Toit Loots (2008) Phytochemical Contents and Antioxidant Capacities of Two Aloe greatheadii var. davyana Extracts Molecules, 13, 2169-2180
Stewart H.L., Snell K.C., Dunham L.J. (1959) National Academy of Sciences-National Research Council, Washington DC, 317-324.
Verheul H. M. W., Hoekman K., Jorna A. S., Smit E. F. and Pinedo H. M. (2000) The Oncologist 5: 45–50.
Bhattacharyya A, Mandal D, Lahiry L, Sa G, Das T (2004) Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio. Cancer Lett 209:147–154
Bredow J, Kretzschmar M, Wunderlich G, Dorr W, Pohl T, Franke WG, Kotzerke J (2004) Therapy of malignant ascites in vivo by 211At-labelled microspheres. Nuklearmedizin 43:63–68
Kanematsu Sugiura (1953) Effect of Various Compounds on the Ehrlich Ascites Carcinoma Cancer Res;13:431-441.
Dongre SH, Badami S, Natesan S, Chandrashekhar RH (2007) Antitumor activity of the methanol extract of Hypericum hookerianum stem against ehrlich ascites carcinoma in swiss albino mice. J Pharmacol Sci 103:354–359
Gupta M, Mazumber UK, Kumar RS, Sivakumar T, Vamsi ML (2004) Antitumor activity and antioxidant status of Caesalpinia bonducella against Ehrlich ascites carcinoma in Swiss albino mice. J Pharmacol Sci 94:177–184
Izhevatkin EV (2004) Practical work on experimental oncology on example of Ehrlich ascitic carcinoma: methodic elaboration. Nauka, Krasnoyarsk
Lin HS, D’Rosario T (2003) Pretreatment growth environment alter the sensitivity of tumor cells to cytotoxic agents. Free Radical Biol Med 35:277–283.
Luksiene Z, Juzenasb P, Moanb J (2006) Radiosensitization of tumours by porphyrins. Cancer Lett 235:40–47.
Kim JH, Evans TS (1964) Effects of X-irradiation on the mitotic cycle of Ehrlich ascites tumor cells. Rad Res 21:129–143.
Nascimento FRT, Cruz GVB, Pereira PVS, Maciel MCG, Silva LA, Azevedo APS, Barroqueiro ESB, Guerra RNM (2006) Ascitic and solid Ehrlich tumor inhibition by Chenopodium ambrosioides L. treatment. Life Sci 78:2650–265.
Nusse M (1981) Cell cycle kinetics of irradiated synchronous and asynchronous tumor cells with DNA distribution analysis and BrdUrd-Hoechst 33258-technique. Cytometry 2:70–79
Prabhakar BT, Khanum SA, Jayashree K, Salimath BP, Shashikanth S (2006) Anti-tumor and proapoptotic effect of novel synthetic benzophenone analogues in Ehrlich ascites tumor cells. Bioorg. Med Chem 14:435–446
Probst H, Schiffer H, Gekeler V, Kienzle-Pfelsticker H, Stropp U, Sto¨tzer KE, Frenzel-Sto¨tzer I (1988) Oxygen dependent regulation of DNA synthesis and growth of Ehrlich ascites tumor cells in vitro and in vivo. Cancer Res 48:2053–2060
L. Chen and J. F. Watkins, “Evidence against the presence of H2 histocompatibility antigens in Ehrlich ascites tumour cells,” Nature, vol. 225, no. 5234, pp. 734–735, 1970.
H. M. Patt and R. L. Straube, “Measurement and nature of ascites tumor growth,” Annals of the New York Academy of Sciences, vol. 63, no. 5, pp. 728–737, 1956.
Darzynkiewicz, Z., Li, X., and Gong, J. 1994. Assays of cell viability: Discrimination of cells dying by apoptosis. Methods Cell Biol. 41:15-38.
B. T. Prabhakar, Shaukath Ara Khanum, K. Jayashree, Bharathi P. Salimath, and S. Shashikanth (2006) Anti-tumor and proapoptotic effect of novel synthetic benzophenone analogues in Ehrlich ascites tumor cells. Bioorg. Med. Chem. 14: 435–446
M. S. Saluja, B. Sangameswaran, I. S. Hura, Ajay Sharma, S.K.Gupta and M. Chaturvedi (2011) In-vitro cytotoxic activity of leaves of Madhuca longifolia against Ehrlich Ascites carcinoma (EAC) cell lines. Int. J. of Drug Discovery & Herbal Research 1(2): 55-57.
Ramakrishna Y, Manohar AL, Mamata P, Shreekant KG (1984). Plants and novel antitumor agents: A review. Indian Drugs 21: 173-185.
Kavimani S, Manisenthil kumar KT (2000). Effect of methanol extract of Enicostemna littorale on Dalton’s lymphoma. J. Ethnopharmacol. 71: 349-352.
Thippeswamy and Bharathi P. Salimath (2006) Curcuma aromatic extract induces apoptosis and inhibits angiogenesis in Ehrlich ascites tumour cells in vivo. mySCIENCE 1(1): 79-92.
A.A. Sowemimo, F.A. Fakoya, I. Awopetu, O.R. Omobuwajo, S.A. Adesanya (2007b) Toxicity and mutagenic activity of some selected Nigerian plants. J. Ethnopharmacol. 113:427–432
Mazumder UK, Gupta M, Maiti S, Mukherjee M (1997). Antitumor activity of Hygrophilaspinosa on Ehrlich ascites carcinoma and sarcoma-180 induced mice. Indian J. Exp. Biol. 35: 473-477.
Gupta M, Mazumder UK, Rath N, Mukhopadhyay DK (2000). Antitumor activity of methanolic extract of Cassia fistula L. seed against Ehrlich ascites carcinoma. J. Ethnopharmacol. 72: 151-156.
Gupta M, Mazumder UK, Sambath Kumar R, Sivakumar T, Mohan vamsi ML (2004). Antitumor Activity and Antioxidant Status of Caesalpinia bonducella Against Ehrlich Ascites Carcinoma in Swiss Albino Mice. J. Pharmacol. Sci. 94: 177-184.
Gordon M. Cragg, David J. Newman (2005) Plants as a source of anti-cancer agents. Journal of Ethnopharmacology (100):72–79.
Abdullaev FI, Luna RR, Roitenburd BV, Espinosa AJ. Pattern of childhood cancer mortility in Mexico. Arch Med Res 2000; 31: 526-31.
G.Z. Justo, N. Duran, M.L.S. Queiroz (2000) Myelopoietic response in tumor-bearing mice by an aggregated polymer isolated from Aspergillus oryzae, Eur. J. Pharmacol. 388: 219–226.
Natalia Bromberg, Juliana L. Dreyfuss, Caio V. Regatieri, Marcelly V. Palladino, Nelson Duran, Helena B. Nader, Marcela Haun, Giselle Z. Justo (2010) Growth inhibition and pro-apoptotic activity of violacein in Ehrlich ascites tumor. Chemico-Biological Interactions. (186) 43–52.
Madhuri S., Pandey G. (2009). Some anticancer medicinal plants of foreign origin. Current Science, 96 (6) 779-783.
Dapar, L. P. Maxwell, Aguiyi, C. John, Wannang, N. Noel, Gyang, S. Steven and Tanko, M. Naanlep (2007) The histopathologic effects of Securidaca longepedunculata on heart, liver, kidney and lungs of rats. Afr. J. Biotechnol. 6 (5): 591-595.
Meenakshi Sundaram Muthuraman, Sundarsanam Dorairaj, Parthasarathy Rangarajan, Brindha Pemaiah (2008) Antitumour and Antioxidant Potential of Tragia Plukenetii R.Smith on Ehrlich ascites carcinoma in mice. Afr. J. Biotechnol. 7 (20): 3527-3530.
Jun-ya UEDA, Yasuhiro TEZUKA, Arjun Hari BANSKOTA, Quan Le TRAN, Qui Kim TRAN, Yuko HARIMAYA, Ikuo SAIKI, and Shigetoshi KADOTA (2002). Antiproliferative Activity of Vietnamese Medicinal Plants. Biol. Pharm. Bull. 25(6) 753—760

Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Review

Authors

Rıdvan Lawal ^*
Nigeria

Mehmet Özaslan
Türkiye

Publication Date

April 26, 2021

Submission Date

April 26, 2021

Acceptance Date

April 26, 2021

Published in Issue

Year 2021 Volume: 2 Number: 2

IZ

https://izlik.org/JA37ED64BL

APA

Lawal, R., & Özaslan, M. (2021). EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW). Zeugma Biological Science, 2(2), 19-27. https://izlik.org/JA37ED64BL

AMA

1.Lawal R, Özaslan M. EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW). zbs. 2021;2(2):19-27. https://izlik.org/JA37ED64BL

Chicago

Lawal, Rıdvan, and Mehmet Özaslan. 2021. “EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW)”. Zeugma Biological Science 2 (2): 19-27. https://izlik.org/JA37ED64BL.

EndNote

Lawal R, Özaslan M (April 1, 2021) EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW). Zeugma Biological Science 2 2 19–27.

IEEE

[1]R. Lawal and M. Özaslan, “EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW)”, zbs, vol. 2, no. 2, pp. 19–27, Apr. 2021, [Online]. Available: https://izlik.org/JA37ED64BL

ISNAD

Lawal, Rıdvan - Özaslan, Mehmet. “EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW)”. Zeugma Biological Science 2/2 (April 1, 2021): 19-27. https://izlik.org/JA37ED64BL.

JAMA

1.Lawal R, Özaslan M. EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW). zbs. 2021;2:19–27.

MLA

Lawal, Rıdvan, and Mehmet Özaslan. “EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW)”. Zeugma Biological Science, vol. 2, no. 2, Apr. 2021, pp. 19-27, https://izlik.org/JA37ED64BL.

Vancouver

1.Rıdvan Lawal, Mehmet Özaslan. EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW). zbs [Internet]. 2021 Apr. 1;2(2):19-27. Available from: https://izlik.org/JA37ED64BL

Abstract

EFFECT OF MEDICINAL PLANTS ON EHRLICH ASCITES CARNINOMA CELLS (A REVIEW)

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

Cite