Laktik Asit Bakterilerinin Antibiyotik Direnç Mekanizmaları

Yıl 2014, Cilt: 28 Sayı: 2, 71 - 82, 01.08.2014

Hacer Meral Mihriban Korukluoğlu

Öz

Anahtar Kelimeler

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Laktik Asit Bakterilerinin Antibiyotik Direnç Mekanizmaları

Öz

Penisilin’in keşfi ile yaklaşık olarak seksen yıldır kullanılan antibiyotikler birçok hastalığa karşı vazgeçilmez savunma mekanizması haline gelmişlerdir. Antibiyotikler hücre duvarı sentezini durdurmak, hücre zarının işlevini bozmak ya da protein sentezini engellemek gibi etkilerle hedef bakteriyi inhibe ederler. Hızla artan aşırı ve bilinçsiz antibiyotik kullanımı bakterilerin antibiyotiklere karşı direnç geliştirmelerine sebep olmuştur. Sonradan kazanılan bu direnç genleri bakteriler arasında taşınabilmektedir. Bu derlemede laktik asit bakterilerinin direnç profilleri ve gen aktarımlarıyla ilgili çalışmalar irdelenmiştir

Anahtar Kelimeler

Antibiyotik direnç, laktik asit bakterileri, doğal direnç, kazanılmış direnç

Kaynakça

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