Year 2019, Volume 58, Issue 1, Pages 21 - 26 2019-03-14

Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy
Laparoskopik sleeve gastrektomi sonrası grelin, leptin ve insülin düzeylerindeki değişiklikler

Varlık Erol [1] , Cengiz Aydın [2] , Levent Uğurlu [3] , Emre Turgut [4] , Hülya Yalçın [5] , Fatma Demet Arslan [6]

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Aim: The objective of this study was to evaluate the effects of laparoscopic sleeve gastrectomy (LSG), performed upon patients with morbid obesity, on weight loss and recovery of comorbid diseases as well as on metabolic and hormonal mechanisms by comparing pre and postoperative hormone levels.

Materials and Methods: 38 patients having undergone LSG between May 2013 and May 2014 were included in the study. In this prospective study, patients’ demographic data and associated diseases; weight loss; pre and post-operative insulin levels in addition to pre and post-operative leptin and ghrelin levels in the eighth weeks were compared.

Results: Of 38 patients included in the study there were 32 (84.2%) females and 6 (15.8%) males. Median leptin level was 11.16 ng/mL in the preoperative blood sample, whereas postoperative hormone level in the eighth week was 4.39 ng/mL. When ghrelin levels were examined; preoperative median was 25.72 pg/mL, whereas postoperative hormone level was 14.16 pg/mL in the eighth week. Preoperative median body mass index was determined to be 44.27 and post-operative median was observed to be 36.6 in the eighth week. No mortality was observed.

Conclusion: Today LSG has become a unique surgical technique in the treatment of morbid obesity due to its efficiency in obtaining weight loss and its feasible complication rates. After reviewing the results of our study; we believe this surgical technique does not only provide continuity in weight loss by restrictive changes but at the same time by metabolic ones, too.

Amaç: Bu çalışmada, morbid obezite tanılı hastalarda tedavi amacıyla uygulanan LSG’nin kilo kaybı ve yandaş hastalıkların tedavisinin yanı sıra metabolik ve hormonal mekanizmalar üzerindeki etkinliğinin, operasyon öncesi ve operasyon sonrası dönemdeki hormon düzeyleri karşılaştırılarak irdelenmesi amaçlandı.
Gereç ve Yöntemler: Mayıs 2013-Mayıs 2014 tarihleri arasında, LSG uygulanan 38 hasta çalışmaya dahil edildi. Prospektif olan bu çalışmada hastaların demografik verileri, yandaş hastalıkları, takipte kilo kaybı, morbidite ve mortalite oranları, operasyon öncesi ve sonrası insülin düzeyleri ile operasyon öncesi ve operasyon sonrası sekizinci haftadaki leptin ve grelin hormonlarının düzeyleri irdelenerek karşılaştırıldı.
Bulgular: Çalışmaya dahil edilen 38 hastadan 32’si (%84.2) kadın, altısı (%15.8) ise erkekti. Operasyon öncesi alınan kandaki leptin düzeylerinin ortalaması 11.16 ng/mL iken, operasyon sonrası sekizinci haftadaki hormon seviyesi 4.39 ng/mL olarak belirlendi. Grelin düzeylerine bakıldığında ise; operasyon öncesi ortalama 25.72 pg/mL iken, operasyon sonrası sekizinci haftadaki hormon seviyesi 14.16 pg/mL olarak belirlendi. Operasyon öncesi ortalama vücut kitle indeksi (VKİ) 44.3, operasyon sonrası sekizinci haftada ise 36.6 olarak belirlendi. Hiçbir hastada mortalite gerçekleşmedi.
Sonuç: LSG, günümüzde mükemmel kilo kaybı sağlaması ve kabul edilebilir oranlarda düşük komplikasyon riskleri nedeniyle morbid obezite tedavisinde tek başına uygulanan bir cerrahi teknik haline gelmiştir. Çalışmamızın sonuçlarına baktığımız zaman; bu ameliyat tekniğinin sadece restriktif değil, aynı zamanda metabolik değişikliklere neden olarak da kilo kaybındaki devamlılığı sağladığı kanaatindeyiz.
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Orcid: 0000-0002-7337-4973
Author: Varlık Erol (Primary Author)
Institution: Başkent University İzmir Research and Practice Center, Clinic of General Surgery, İzmir
Country: Turkey


Orcid: 0000-0003-4713-2871
Author: Cengiz Aydın
Institution: Tepecik Training and Research Center, Clinic of General Surgery, İzmir
Country: Turkey


Orcid: 0000-0002-9415-2974
Author: Levent Uğurlu
Institution: Tepecik Training and Research Center, Clinic of General Surgery, İzmir
Country: Turkey


Orcid: 0000-0001-8196-1871
Author: Emre Turgut
Institution: Tepecik Training and Research Center, Clinic of General Surgery, İzmir
Country: Turkey


Orcid: 0000-0001-5224-8372
Author: Hülya Yalçın
Institution: Tepecik Training and Research Center, Clinic of General Surgery, İzmir
Country: Turkey


Orcid: 0000-0003-0766-0303
Author: Fatma Demet Arslan
Institution: Tepecik Training and Research Center, Clinic of Biochemistry, İzmir
Country: Turkey


Bibtex @research article { etd418130, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {Ege University}, year = {2019}, volume = {58}, pages = {21 - 26}, doi = {10.19161/etd.418130}, title = {Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy}, key = {cite}, author = {Erol, Varlık and Aydın, Cengiz and Uğurlu, Levent and Turgut, Emre and Yalçın, Hülya and Arslan, Fatma Demet} }
APA Erol, V , Aydın, C , Uğurlu, L , Turgut, E , Yalçın, H , Arslan, F . (2019). Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy. Ege Tıp Dergisi, 58 (1), 21-26. DOI: 10.19161/etd.418130
MLA Erol, V , Aydın, C , Uğurlu, L , Turgut, E , Yalçın, H , Arslan, F . "Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy". Ege Tıp Dergisi 58 (2019): 21-26 <http://dergipark.org.tr/etd/issue/43429/418130>
Chicago Erol, V , Aydın, C , Uğurlu, L , Turgut, E , Yalçın, H , Arslan, F . "Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy". Ege Tıp Dergisi 58 (2019): 21-26
RIS TY - JOUR T1 - Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy AU - Varlık Erol , Cengiz Aydın , Levent Uğurlu , Emre Turgut , Hülya Yalçın , Fatma Demet Arslan Y1 - 2019 PY - 2019 N1 - doi: 10.19161/etd.418130 DO - 10.19161/etd.418130 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 21 EP - 26 VL - 58 IS - 1 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.418130 UR - https://doi.org/10.19161/etd.418130 Y2 - 2018 ER -
EndNote %0 Ege Journal of Medicine Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy %A Varlık Erol , Cengiz Aydın , Levent Uğurlu , Emre Turgut , Hülya Yalçın , Fatma Demet Arslan %T Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy %D 2019 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 58 %N 1 %R doi: 10.19161/etd.418130 %U 10.19161/etd.418130
ISNAD Erol, Varlık , Aydın, Cengiz , Uğurlu, Levent , Turgut, Emre , Yalçın, Hülya , Arslan, Fatma Demet . "Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy". Ege Tıp Dergisi 58 / 1 (March 2019): 21-26. https://doi.org/10.19161/etd.418130