Year 2016, Volume 2, Issue 3, Pages 211 - 218 2016-08-28

Relation of neutrophil/lymphocyte ratio to resistant hypertension

Necati Dagli [1] , Orhan Dogdu [2] , Omer Senarslan [3] , Hasan Yucel [4] , Hakki Kaya [5] , Mahmut Akpek [6] , Semih Eriten [7]

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Objectives. Resistant hypertension has unfavourable effects on cardiovascular and other systems. The aim of this study was to investigate the association of neutrophil/lymphocyte (N/L) ratio and resistant hypertension. Methods. A total of 140 patients were included in the study. Ambulatory 24-hour blood pressure monitoring, transthoracic echocardiography and blood sample analyzing were performed in all patients. There were 60 patients with resistant hypertension group (mean age=55.1±9.7 years) and 80 patients with non-resistant hypertension group (mean age=56.8±14.1 years). Results. Mean neutrophil levels were significantly higher in resistant hypertension group (71.7±6.1% vs. 65.9±5.4%, p<0.001), while lymphocyte levels were significantly higher in non-resistant hypertension group (22±4.7% vs. 17.5±4.1%, p<0.001). N/L ratio was significantly higher in resistant hypertension group (4.3±1.2 vs. 3.1±0.9, p<0.001). In multivariate analysis, diabetes mellitus (odds ratio [OR]=2.857; 95% confidence interval [CI], 1.349-6.053; p=0.006), N/L ratio (OR=2.699; 95% CI, 1.821-4.002; p<0.001) and obesity (OR=3.429; 95% CI, 1.675-7.019; p=0.001) were independent predictors of resistant hypertension. Conclusion. The N/L ratio, which is cheaply and easily measurable laboratory data, is independently associated with resistant hypertension. 

Resistant hypertension, ambulatory blood pressure monitoring; neutrophil/lymphocyte ratio
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Journal Section Original Articles

Author: Necati Dagli
Institution: Department of Cardiology, Firat University School of Medicine, Elazig
Country: Turkey

Author: Orhan Dogdu
Institution: Department of Cardiology, Firat University School of Medicine, Elazig
Country: Turkey

Author: Omer Senarslan
Institution: Department of Cardiology, Private Medifema Hospital, Izmir
Country: Turkey

Author: Hasan Yucel
Institution: Department of Cardiology, Cumhuriyet University School of Medicine, Sivas
Country: Turkey

Author: Hakki Kaya
Institution: Department of Cardiology, Cumhuriyet University School of Medicine, Sivas
Country: Turkey

Author: Mahmut Akpek
Institution: Department of Cardiology, Adnan Menderes University School of Medicine, Aydin
Country: Turkey

Author: Semih Eriten
Institution: Department of Emergency Medicine, Malatya State Hospital, Malatya
Country: Turkey

EndNote %0 The European Research Journal Relation of neutrophil/lymphocyte ratio to resistant hypertension %A Necati Dagli , Orhan Dogdu , Omer Senarslan , Hasan Yucel , Hakki Kaya , Mahmut Akpek , Semih Eriten %T Relation of neutrophil/lymphocyte ratio to resistant hypertension %D 2016 %J The European Research Journal %P -2149-3189 %V 2 %N 3 %R doi: 10.18621/eurj.2016.5000185856 %U 10.18621/eurj.2016.5000185856