Year 2016, Volume 2, Issue 1, Pages 46 - 51 2016-03-04

Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis

Ozlem Arican Ozluk [1] , Mustafa Yilmaz [2] , Dursun Topal [3] , Erhan Tenekecioglu [4] , Selcuk Kanat [5] , Fahriye Vatansever [6] , Tezcan Peker [7] , Kemal Karaagac [8] , Bedrettin Boyraz [9]

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Objectives. Many systemic diseases including cardiovascular disturbances have been described in psoriatic patients. In the previous studies, left ventricle (LV) subclinical myocardial dysfunction was reported in the psoriasis patients. The T-wave peak to end (Tp-e) interval is a relatively new marker for ventricular arrhythmogenesis and repolarization heterogeneity. Prolongation of this interval represents a period of potential vulnerability to ventricular arrhythmias. However, there is no information available assessing the Tp-e interval and related calculations in patients with psoriasis disease. The aim of this study was to evaluate ventricular repolarization in patients with psoriasis disease by using QT, corrected QT (QTc) and Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio. Methods. In this study, retrospective analysis of 30 patients who underwent the psoriasis treatment and of 30 healthy individuals was performed. The severity of the disease was evaluated by the “Psoriasis Area and Severity Index”. QT, corrected QT (QTc), Tp-e interval and Tp-e/QT ratio were measured by means of the 12-lead electrocardiogram. Left ventricular function was evaluated by echocardiography. Results. Baseline characteristics and QT and QTc intervals were similar in both groups. No difference was detected between the groups with regards to Tp-e interval (83.0±9 vs 82.3±10; p=0.81), Tp-e/QT (0.22±0.03 vs 0.23±0.04; p=0.3) and Tp-Te/QTc (0.20±0.04 vs 0.19±0.04; p=0.77). Conclusions. These findings suggest that ventricular repolarization in mild to moderate psoriasis patients might be unimpaired. Larger samples and severe degree psoriasis patients are needed to evaluate the arrhythmia risk in psoriasis patients.

Psoriasis, Tp-Te interval; Tp-Te/QT ratio
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Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Author: Ozlem Arican Ozluk
Institution: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Country: Turkey


Author: Mustafa Yilmaz
Institution: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Country: Turkey


Author: Dursun Topal
Institution: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Country: Turkey


Author: Erhan Tenekecioglu
Institution: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Country: Turkey


Author: Selcuk Kanat
Institution: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Country: Turkey


Author: Fahriye Vatansever
Institution: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Country: Turkey


Author: Tezcan Peker
Institution: Department of Cardiology, Bursa Doruk Hospital, Bursa
Country: Turkey


Author: Kemal Karaagac
Institution: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Country: Turkey


Author: Bedrettin Boyraz
Institution: Department of Cardiology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa
Country: Turkey


EndNote %0 The European Research Journal Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis %A Ozlem Arican Ozluk , Mustafa Yilmaz , Dursun Topal , Erhan Tenekecioglu , Selcuk Kanat , Fahriye Vatansever , Tezcan Peker , Kemal Karaagac , Bedrettin Boyraz %T Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis %D 2016 %J The European Research Journal %P -2149-3189 %V 2 %N 1 %R doi: 10.18621/eurj.2016.2.1.46 %U 10.18621/eurj.2016.2.1.46