Year 2019, Volume 5, Issue 1, Pages 94 - 97 2019-01-04

Neurological findings in autosomal dominant polycystic kidney disease

Demet Yıldız [1] , Abdülmecit Yıldız [2]

95 335

Objective: Autosomal dominant polycystic kidney disease (ADPKD) mainly affects the kidneys, but other abnormalities like intracranial aneurysms (ICAs) are not uncommon. In this study, we aimed to investigate retrospectively frequency of ICA and other neurological abnormalities in ADPKD patients.

Methods: One hundred and forty patients with ADPKD who did not receive replacement therapy and followed-up at outpatient clinic were evaluated.

Results: The mean age of the patients was 43.4 ± 13 years and mean glomerular filtration rate was 87 ± 15 ml/min. ICA was detected in four (2.8%) patients. Three patients were from the same family. Thirteen (9.3%) patients had magnetic resonance angiography due to their family stories, but aneurysm was not seen in them.

Conclusion: Individuals with ADPKD who have a history of aneurysm or hemorrhage in their family should be screened for aneurysm due to mortality and risk of recurrent rupture. 

Autosomal dominant, polycystic kidney disease, intracranial aneurysms, arachnoid cysts
  • [1] Torres VE, Harris PC, Pirson Y. Autosomal dominant polycystic kidney disease. Lancet 2007;369:1287-301.
  • [2] Chebib FT, Torres VE. Autosomal dominant polycystic kidney disease: core curriculum 2016. Am J Kidney Dis 2016;67:792-810.
  • [3] Luciano RL, Dahl NK. Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management. Nephrol Dial Transplant 2014;29:247-54.
  • [4] Leung GK, Fan YW. Chronic subdural haematoma and arachnoid cyst in autosomal dominant polycystic kidney disease (ADPKD). J Clin Neurosci 2005;12:817-9.
  • [5] Belz MM, Fick-Brosnahan GM, Hughes RL, Rubinstein D, Chapman AB, Johnson AM, et al. Recurrence of intracranial aneurysms in autosomal-dominant polycystic kidney disease. Kidney Int 2003;63:1824-30.
  • [6] Pei Y, Obaji J, Dupuis A, Paterson AD, Magistroni R, Dicks E, et al. Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol 2009;20:205-12.
  • [7] Xu HW, Yu SQ, Mei CL, Li MH. Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease. Stroke 2011;42:204-6.
  • [8] Cagnazzo F, Gambacciani C, Morganti R, Perrini P. Intracranial aneurysms in patients with autosomal dominant polycystic kidney disease: prevalence, risk of rupture, and management. A systematic review. Acta Neurochir (Wien) 2017;159:811-21.
  • [9] Schrier RW, Belz MM, Johnson AM, Kaehny WD, Hughes RL, Rubinstein D, et al. Repeat imaging for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease with initially negative studies: a prospective ten-year follow-up. J Am Soc Nephrol 2004;15:1023-8.
Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Orcid: 0000-0003-0807-8980
Author: Demet Yıldız (Primary Author)
Institution: Department of Neurology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0001-5941-9103
Author: Abdülmecit Yıldız
Institution: Department of Neurology, Uludağ University School of Medicine, Bursa, Turkey
Country: Turkey


Dates

Publication Date: January 4, 2019

EndNote %0 The European Research Journal Neurological findings in autosomal dominant polycystic kidney disease %A Demet Yıldız , Abdülmecit Yıldız %T Neurological findings in autosomal dominant polycystic kidney disease %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 1 %R doi: 10.18621/eurj.379970 %U 10.18621/eurj.379970