Objectives:
Different materials are currently being used experimentally to accelerate
cartilage healing and to obtain hyaline cartilage. We aimed to investigate the
effect of platelet-rich fibrin on joint cartilage healing.
Methods:
Twenty rats were used in this study. platelet-rich fibrin was obtained from
4 rats, and the remaining 16 rats were randomly divided into two groups (4 and
8 weeks). Both knee joints were prepared, and an osteochondral
defect was created at the femoral condyle in all rats.
platelet-rich fibrin was placed into the osteochondral defect of the right
knee, while the left knee joint was used as a control. Groups were sacrificed
after 4 and 8 weeks, respectively.
Results:
According to the O'Driscoll score, there were no significant differences
between the right and left knee scores in group 4 weeks (p = 0.820). However, the right knee scores were
significantly different than the left knee scores in group 8 weeks (p < 0.001). Defects were completely filled with cartilage tissue
after 8 weeks in the platelet-rich fibrin group.
Conclusions:
Similar to its role in various tissues, platelet-rich
fibrin is an effective biomaterial that enhances the healing of osteochondral
defects.
Articular cartilage chondral healing experimental rat model hyaline cartilage platelet-rich fibrin
Birincil Dil | İngilizce |
---|---|
Konular | Sağlık Kurumları Yönetimi |
Bölüm | Original Article |
Yazarlar | |
Yayımlanma Tarihi | 4 Mart 2019 |
Gönderilme Tarihi | 1 Ocak 2018 |
Kabul Tarihi | 1 Temmuz 2018 |
Yayımlandığı Sayı | Yıl 2019 Cilt: 5 Sayı: 2 |