Year 2019, Volume 5, Issue 3, Pages 522 - 528 2019-05-04

Evaluation of plasma catestatin levels in patient with coronary slow flow

Dursun Topal [1] , Bedrettin Boyraz [2] , Alkame Akgümüş [3] , Tezcan Peker [4] , Mustafa Yılmaz [5] , Fahriye Vatansever Ağca [6] , Selçuk Kanat [7] , Ömür Aydın [8] , Burhan Aslan [9]

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Objectives: Coronary slow flow (CSF) is characterized by delayed opasification of the coronary arteries in the absence of obstructive coronary disease. Catestatin has several cardiovasculer actions, in addition to diminihed sympato-adrenal flow. The study was to investigated associations between CSF and plasma catestatin levels.

Method:. This study included 45 CSF patients (37 male, mean age 48 ± 9.5 years) and 30 control individuals (24 male, mean age 48.4 ± 9 years). Coronary flow was quantified according to the TIMI (Thrombolysis in Myocardial Infarction) frame count method for coronary arteries. Serum catestatin levels taken from blood samples were measured by ELISA method. These parameters were compared between the groups.

Results: When compared with to the control group the serum catestatin levels was found higher in the CSF group. In addition to this, mean platelet volume was also significantly higher in patients with coronary slow flow.

Conclusions: Our study revealed that catestatin levels are increased in patients with CSF. Coronary slow flow that increased catecholaminergic sympathetic system activities seem to be among the reasons of endothelial dysfunction. 

catestatin, coronary slow flow, coronary artery disease
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Orcid: 0000-0001-7053-2131
Author: Dursun Topal (Primary Author)
Institution: Department of Cardiology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0003-1831-182X
Author: Bedrettin Boyraz
Institution: Department of Cardiology, Bitlis Tatvan State Hospital, Bitlis, Turkey
Country: Turkey


Orcid: 0000-0002-4286-8997
Author: Alkame Akgümüş
Institution: Department of Cardiology, Gemlik State Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0002-2489-5430
Author: Tezcan Peker
Institution: Department of Cardiology, Bursa Doruk Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0002-3616-0028
Author: Mustafa Yılmaz
Institution: Department of Cardiology, Uludağ University School of Medicine, Bursa, Turkey
Country: Turkey


Orcid: 0000-0002-1401-2980
Author: Fahriye Vatansever Ağca
Institution: Department of Cardiology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0002-1211-6532
Author: Selçuk Kanat
Institution: Department of Cardiology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey
Country: Turkey


Orcid: 0000-0002-8531-2550
Author: Ömür Aydın
Institution: Department of Cardiology, Kilis State Hospital, Kilis, Turkey
Country: Turkey


Orcid: 0000-0002-8994-7414
Author: Burhan Aslan
Institution: Department of Cardiology, Mardin Kızıltepe State Hospital, Mardin, Turkey
Country: Turkey


EndNote %0 The European Research Journal Evaluation of plasma catestatin levels in patient with coronary slow flow %A Dursun Topal , Bedrettin Boyraz , Alkame Akgümüş , Tezcan Peker , Mustafa Yılmaz , Fahriye Vatansever Ağca , Selçuk Kanat , Ömür Aydın , Burhan Aslan %T Evaluation of plasma catestatin levels in patient with coronary slow flow %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 3 %R doi: 10.18621/eurj.372631 %U 10.18621/eurj.372631