Year 2019, Volume 5, Issue 4, Pages 641 - 648 2019-07-04

Investigation of effects of neurotrophic factors on painful diabetic neuropathy: an experimental study

Faruk Kılınç [1] , Ramis Çolak [2] , Mete Özcan [3] , Ahmet Ayar [4]

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Objective: We have studied the effects of neurotrophin-4 (NT-4) different doses on the pain levels of streptozocin-induced diabetic rats.

Methods: Thirty-five 3-week-old male rats were used. After induction of diabetes in rats with streptozocin (nearly 4 weeks); diabetic animals were divided into 4 groups. The first group; healthy control group (n = 15 ), the second group; diabetic control group ( n = 10 ), the third group; low dose (0.3 mg/ kg ) recombinant human NT-4 was applied ( n = 4 ) and the fourth group; high dose recombinant human NT-4 was applied (n = 6).

Results: In the low-dose NT-4 group, the pain threshold values did not differ from the diabetic control and healthy control groups. In the high dose NT-4 group, a rise was observed in the pain threshold values of hot plate in comparison with the healthy control group, diabetic control group and low dose applied group and this rise reached at the level of statistical significance (p < 0.05).

Conclusion: Neurotrophic factors (neurotrophin-4) have been shown to be effective on painful diabetic neuropathy in streptozocin-induced diabetic rats. However, there is a need for larger-scale and longer-term studies for clinical use. 

Diabetic neuropathy, hot plate, neurotrophin-4, streptozocin
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Articles

Orcid: 0000-0002-0198-2558
Author: Faruk Kılınç (Primary Author)
Institution: Department of Endocrinology, Fırat University School of Medicine, Elazığ, Turkey
Country: Turkey

Orcid: 0000-0001-8323-0781
Author: Ramis Çolak
Institution: Department of Endocrinology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey
Country: Turkey

Orcid: 0000-0002-5551-4880
Author: Mete Özcan
Institution: Department of Physiology, Fırat University School of Medicine, Elazığ, Turkey
Country: Turkey

Orcid: 0000-0002-9449-9564
Author: Ahmet Ayar
Institution: Department of Physiology, Karadeniz Technical University School of Medicine, Trabzon, Turkey
Country: Turkey


Publication Date: July 4, 2019

EndNote %0 The European Research Journal Investigation of effects of neurotrophic factors on painful diabetic neuropathy: an experimental study %A Faruk Kılınç , Ramis Çolak , Mete Özcan , Ahmet Ayar %T Investigation of effects of neurotrophic factors on painful diabetic neuropathy: an experimental study %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 4 %R doi: 10.18621/eurj.414105 %U 10.18621/eurj.414105