Year 2019, Volume 9, Issue 1, Pages 1 - 8 2019-03-27

Romatoid Artrit ve Ankilozan Spondilitli Hastalarda Anti-TNF İlaç Kullanımının Üriner Enfeksiyon Gelişimine Etkisi
Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

Mehmet Ali Uçar [1] , Mehmet Sayarlıoğlu [2]

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Amaç: Bu çalışmada hedefimiz, anti-Tümör Nekroz Faktörü alfa (TNFa) kullanan hastalarda hastalık modifiye edici anti-romatizmal ilaçlar (DMARD) kullanan hastalarla karşılaştırıldığında idrar enfeksiyonlarının sıklığında bir artış olup olmadığını araştırmaktır.

Yöntemler: Anti-TNF ajanlarının ilk kez başlatıldığı 29 romatoid artritli (RA) hasta ve 20 adet Ankylosing Spondylitis (AS) hasta ve 30 sağlıklı kontrol çalışmaya dahil edildi. Ek olarak, anti-TNF ilaçlarının idrar enfeksiyonlarının gelişimi üzerindeki etkilerini daha iyi ortaya çıkarmak için DMARD kullanan 29 RA ve 20 AS hastası çalışmaya dahil edildi.

Bulgular: Anti-TNF tedavisine başlamadan önce aktif hastalığı olan ve anti-TNF tedavisine başlanan hastalar ile DMARD kullanan hastalar arasında üriner enfeksiyon gelişim sıklığı bakımından farklılıklara rağmen anlamlı bir fark yoktu. hastalık aktivitesinde. Anti-TNF ajanları ve DMARD kullanan AS hastaları idrar enfeksiyonlarının gelişim sıklığı açısından sağlıklı kontrol grubu ile karşılaştırıldığında; DMARD grubunda anlamlı bir fark bulunmazken, 2. ve 3. ziyaretlerde anti-TNF grubunda daha sık rastlandı. Anti-TNF tedavisinin, DMARD tedavisine kıyasla idrar yolu enfeksiyonlarının gelişme sıklığı için ek bir risk oluşturduğu tespit edildi.

Sonuç: Anti-TNF tedavisi, RA ve AS hastalarında hastalık aktivitesini kontrol altında tutma konusunda oldukça etkili olsa da, enfeksiyon riskindeki artış nedeniyle daima dikkatli olmak gerekir.

Background: Our objective in this study is to investigate whether there is an increase in frequency of urinary infections in patients using anti-Tumor Necrosis Factor alpha (TNFα) compared to the patients using disease-modifying anti-rheumatic drugs (DMARD).

Methods: 29 patients with rheumatoid arthritis (RA) and 20 patients with Ankylosing Spondylitis (AS), for whom anti-TNF agents were initiated for the first time, and 30 healthy controls were included in the study. Additionally, in order to reveal effects of anti-TNF medications on development of urinary infections better, 29 RA and 20 AS patients using DMARDs were also included in the study.

Result: There was no significant difference in regard to frequency of development of urinary infections between patients with active disease before anti-TNF treatment for whom initiation of anti-TNF treatment was considered and the patients without active disease who were using DMARDs, despite of differences in disease activity. When the AS patients using anti-TNF agents and DMARDs were compared with the healthy control group in regard to frequency of development of urinary infections; while there was no significant difference in the DMARD group, it was more frequently encountered in the anti-TNF group at 2nd and 3rd visits. Anti-TNF treatment was determined to pose an additional risk for frequency of development of urinary infections compared to DMARD treatment.

Conclusion: Although anti-TNF treatment is quite effective in taking disease activity under control in RA and AS patients, it is always necessary to be alert due to increased risk for infection. 

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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Research
Authors

Author: Mehmet Ali Uçar (Primary Author)
Country: Turkey


Author: Mehmet Sayarlıoğlu
Country: Turkey


Dates

Publication Date: March 27, 2019

Bibtex @research article { gopctd528264, journal = {Çağdaş Tıp Dergisi}, issn = {}, eissn = {2146-6009}, address = {Rabia YILMAZ}, year = {2019}, volume = {9}, pages = {1 - 8}, doi = {10.16899/gopctd.528264}, title = {Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis}, key = {cite}, author = {Uçar, Mehmet Ali and Sayarlıoğlu, Mehmet} }
APA Uçar, M , Sayarlıoğlu, M . (2019). Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. Çağdaş Tıp Dergisi, 9 (1), 1-8. DOI: 10.16899/gopctd.528264
MLA Uçar, M , Sayarlıoğlu, M . "Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis". Çağdaş Tıp Dergisi 9 (2019): 1-8 <http://dergipark.org.tr/gopctd/issue/44052/528264>
Chicago Uçar, M , Sayarlıoğlu, M . "Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis". Çağdaş Tıp Dergisi 9 (2019): 1-8
RIS TY - JOUR T1 - Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis AU - Mehmet Ali Uçar , Mehmet Sayarlıoğlu Y1 - 2019 PY - 2019 N1 - doi: 10.16899/gopctd.528264 DO - 10.16899/gopctd.528264 T2 - Çağdaş Tıp Dergisi JF - Journal JO - JOR SP - 1 EP - 8 VL - 9 IS - 1 SN - -2146-6009 M3 - doi: 10.16899/gopctd.528264 UR - https://doi.org/10.16899/gopctd.528264 Y2 - 2019 ER -
EndNote %0 Çağdaş Tıp Dergisi Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis %A Mehmet Ali Uçar , Mehmet Sayarlıoğlu %T Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis %D 2019 %J Çağdaş Tıp Dergisi %P -2146-6009 %V 9 %N 1 %R doi: 10.16899/gopctd.528264 %U 10.16899/gopctd.528264
ISNAD Uçar, Mehmet Ali , Sayarlıoğlu, Mehmet . "Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis". Çağdaş Tıp Dergisi 9 / 1 (March 2019): 1-8. https://doi.org/10.16899/gopctd.528264
AMA Uçar M , Sayarlıoğlu M . Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. J Contemp Med. 2019; 9(1): 1-8.
Vancouver Uçar M , Sayarlıoğlu M . Effect of Use of Anti-TNF Medications on Development of Urinary Infections in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. Çağdaş Tıp Dergisi. 2019; 9(1): 8-1.