Year 2015, Volume 5, Issue 1, Pages 8 - 12 2015-03-04

İkinci Trimester Gebeliklerde Maternal Serum Alfa Feto Protein (AFP) Yüksekliği ve Ultrasonografi Bulguları

Bülent Çakmak [1] , Zeki Özsoy [2] , Fulya Metin [3] , Mehmet Nacar [4] , Selim Gülücü [5] , İsmail Sağ [6]

437 2017

Objective: The aim of this study was to evaluate the findings of second trimester fetal anatomic ultrasound scan in pregnant women with high level Alpha Feto Protein (AFP) in triple test. Methods: Triple test results of 8552 pregnant women were evaluated in a university hospital between January 2011 and December 2013. Fetal anatomic ultrasound scan results of pregnant women who had AFP level ≥2.5 multiples of median (MoM) in triple test were investigated for presence of pathologic findings. Results: AFP levels were detected over 2.5 MoM in 122 (1.14%) of 8552 pregnant women. There were no pathologic findings in 85.2% (104/122) of cases, but 14.8% (18/122) of cases had pathologic results; neural tube defect (NTD) 9% (11/122) and anhidroamnios 2.5% (3/122). Omphalocele, polycystic kidney, sacrococcygeal teratoma, placental chorangioma were detected in 0.8% ratio. NTDs were found in 11 (0.12%) of 8552 pregnant women who evaluated for maternal serum AFP (MSAFP). Conclusion: The routine use of MSAFP may be queried in NTD screening due to common usage of sufficient fetal anatomic ultrasound scan

Amaç: Bu çalışmanın amacı üçlü testte Alfa Feto Protein (AFP) yüksekliği saptanan gebelerde ikinci trimester ayrıntılı ultrasonografi bulgularının irdelenmesidir.

Yöntem: Ocak 2011 - Aralık 2013 tarihleri arasında bir üniversite hastanesi gebe polikliniğinde üçlü test yapılan 8552 gebenin test sonuçları değerlendirildi. Üçlü test sonucunda AFP değeri ≥2.5 multiples of median (MoM) çıkan gebelerin ikinci düzey (ayrıntılı) ultrasonografi sonuçları patolojik bulguların varlığı açısından değerlendirildi.

Bulgular: Değerlendirmeye alınan 8552 gebenin 122(%1.14)'sinde AFP değeri 2.5 MoM üzerinde saptandı. İkinci düzey ultrasonografide olguların %85.2 (104/122)'inde patoloji saptanmazken %14.8 (18/122)'sinde patolojik bulgu tespit edildi; %9 (11/122)'sinde nöral tüp defekti (NTD) (Chiary tip-II) ve %2.5 (3/122)'sinde anhidroamnios saptandı. Omfalosel, polikistik böbrek, sakrokoksigeal teratom ve plasental koranjioma ise %0.8 oranında saptandı. Maternal serum AFP (MSAFP) değerlendirilmesi yapılan 8552 gebenin 11'inde (%0.12) NTD saptandı.

Sonuç: Yeterli ultrasonografik anatomik incelemenin yaygın olarak yapılması nedeniyle fetal NTD taramasında MSAFP'nin rutin kullanımı sorgulanabilir.

 

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Primary Language tr
Subjects
Journal Section Original Research
Authors

Author: Bülent Çakmak

Author: Zeki Özsoy

Author: Fulya Metin

Author: Mehmet Nacar

Author: Selim Gülücü

Author: İsmail Sağ

Bibtex @ { gopctd95732, journal = {Çağdaş Tıp Dergisi}, issn = {}, eissn = {2146-6009}, address = {Selcuk University}, year = {2015}, volume = {5}, pages = {8 - 12}, doi = {10.16899/ctd.26653}, title = {İkinci Trimester Gebeliklerde Maternal Serum Alfa Feto Protein (AFP) Yüksekliği ve Ultrasonografi Bulguları}, key = {cite}, author = {Çakmak, Bülent and Özsoy, Zeki and Metin, Fulya and Nacar, Mehmet and Gülücü, Selim and Sağ, İsmail} }
APA Çakmak, B , Özsoy, Z , Metin, F , Nacar, M , Gülücü, S , Sağ, İ . (2015). İkinci Trimester Gebeliklerde Maternal Serum Alfa Feto Protein (AFP) Yüksekliği ve Ultrasonografi Bulguları. Çağdaş Tıp Dergisi, 5 (1), 8-12. DOI: 10.16899/ctd.26653
MLA Çakmak, B , Özsoy, Z , Metin, F , Nacar, M , Gülücü, S , Sağ, İ . "İkinci Trimester Gebeliklerde Maternal Serum Alfa Feto Protein (AFP) Yüksekliği ve Ultrasonografi Bulguları". Çağdaş Tıp Dergisi 5 (2015): 8-12 <http://dergipark.org.tr/gopctd/issue/7315/95732>
Chicago Çakmak, B , Özsoy, Z , Metin, F , Nacar, M , Gülücü, S , Sağ, İ . "İkinci Trimester Gebeliklerde Maternal Serum Alfa Feto Protein (AFP) Yüksekliği ve Ultrasonografi Bulguları". Çağdaş Tıp Dergisi 5 (2015): 8-12
RIS TY - JOUR T1 - İkinci Trimester Gebeliklerde Maternal Serum Alfa Feto Protein (AFP) Yüksekliği ve Ultrasonografi Bulguları AU - Bülent Çakmak , Zeki Özsoy , Fulya Metin , Mehmet Nacar , Selim Gülücü , İsmail Sağ Y1 - 2015 PY - 2015 N1 - doi: 10.16899/ctd.26653 DO - 10.16899/ctd.26653 T2 - Çağdaş Tıp Dergisi JF - Journal JO - JOR SP - 8 EP - 12 VL - 5 IS - 1 SN - -2146-6009 M3 - doi: 10.16899/ctd.26653 UR - https://doi.org/10.16899/ctd.26653 Y2 - 2019 ER -
EndNote %0 Çağdaş Tıp Dergisi İkinci Trimester Gebeliklerde Maternal Serum Alfa Feto Protein (AFP) Yüksekliği ve Ultrasonografi Bulguları %A Bülent Çakmak , Zeki Özsoy , Fulya Metin , Mehmet Nacar , Selim Gülücü , İsmail Sağ %T İkinci Trimester Gebeliklerde Maternal Serum Alfa Feto Protein (AFP) Yüksekliği ve Ultrasonografi Bulguları %D 2015 %J Çağdaş Tıp Dergisi %P -2146-6009 %V 5 %N 1 %R doi: 10.16899/ctd.26653 %U 10.16899/ctd.26653
ISNAD Çakmak, Bülent , Özsoy, Zeki , Metin, Fulya , Nacar, Mehmet , Gülücü, Selim , Sağ, İsmail . "İkinci Trimester Gebeliklerde Maternal Serum Alfa Feto Protein (AFP) Yüksekliği ve Ultrasonografi Bulguları". Çağdaş Tıp Dergisi 5 / 1 (March 2015): 8-12. https://doi.org/10.16899/ctd.26653