Year 2018, Volume 1, Issue 3, Pages 15 - 15 2018-12-08

Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones

Efrain ALDAY [1] , Lucía URIBE [2] , Dora VALENCIA [3] , Adriana GARIBAY-ESCOBAR [4] , Anna Lisa PICCINELLI [5] , Luca RASTRELLI [6] , Humberto ASTIAZARÁN-GARCÍA [7] , Ramón Enrique ROBLES-ZEPEDA [8] , Javier HERNANDEZ [9] , Carlos VELAZQUEZ [10]

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The main chemical composition of Sonoran propolis (SP), as well as its antiproliferative activity on cancer cells via apoptosis induction has been reported1. Additionally, the chemical constitution of SP remained qualitatively similar throughout the year, whereas the antiproliferative effect exhibited significant differences amongst seasonal samples2. The goal of this study was to authenticate the botanical source of SP bioactivity by using an approach based on a chemical comparative analysis, antiproliferative activity and cell cycle progression analysis on cancer cell lines. The polyphenolic profile of SP throughout the year resulted to be qualitatively similar to that of Populus fremontii resins (PFR). However, the antiproliferative activity of PFR did not consistently match that exhibited by SP. In addition, SP induced evident morphological modifications (elongation) on treated cells, different to those induced by PFR. Most of cancer cells treated with SP were arrested in G2/M checkpoint (M12.C3.F6: 94.8±1.7 %, and HeLa cells: 70.8±5.7 %), similarly as colchicine did (control drug; 2 µM; 94.8±2.3 % and 72.7±6.4 %, respectively). In contrast, PFR treatment increased cell population at G0/G1 on both M12.C3.F6 (56.9±5.0 %) and HeLa cells (70.3±0.3 %), in comparison with dissolvent control. Interestingly, Ambrosia confertiflora resins induced morphological elongation and cell cycle arrest at G2/M on both M12.C3.F6 and HeLa cells, similarly as SP did. These results suggest that P. fremontii is the main plant origin of SP, nevertheless, A. confertiflora resins participate as a complementary source that enhances its bioactivity. Therefore, SP is a poplar-type propolis from subtropical semi-arid zones. 
Sonoran Propolis, Antiproliferative Effect, P. fremontii
  • 1. Alday E, Valencia D, Carreсo AL, Picerno P, Piccinelli AL, Rastrelli L, Robles-Zepeda R, Hernandez J, Velazquez C (2015) Apoptotic induction by pinobanksin and some of its ester derivatives from Sonoran propolis in a B-cell lymphoma cell line. Chemico-Biological Interactions 242: 35–44. 2.Valencia D, Alday E, Robles-Zepeda R, Garibay-Escobar A, Galvez-Ruiz JC, Salas-Reyes M, Jimйnez-Estrada M, Velazquez-Contreras E, Hernandez J, Velazquez C (2012). Seasonal effect on chemical composition and biological activities of Sonoran propolis. Food Chemistry 131: 645–651.
Primary Language en
Subjects
Journal Section 2nd Propolis Conference Special Issue
Authors

Author: Efrain ALDAY

Author: Lucía URIBE

Author: Dora VALENCIA

Author: Adriana GARIBAY-ESCOBAR

Author: Anna Lisa PICCINELLI

Author: Luca RASTRELLI

Author: Humberto ASTIAZARÁN-GARCÍA

Author: Ramón Enrique ROBLES-ZEPEDA

Author: Javier HERNANDEZ (Primary Author)

Author: Carlos VELAZQUEZ (Primary Author)

Bibtex @conference paper { jan488597, journal = {Journal of Apitherapy and Nature}, issn = {}, eissn = {2667-4734}, address = {Oktay YILDIZ}, year = {2018}, volume = {1}, pages = {15 - 15}, doi = {}, title = {Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones}, key = {cite}, author = {ALDAY, Efrain and URIBE, Lucía and VALENCIA, Dora and GARIBAY-ESCOBAR, Adriana and PICCINELLI, Anna Lisa and RASTRELLI, Luca and ASTIAZARÁN-GARCÍA, Humberto and ROBLES-ZEPEDA, Ramón Enrique and HERNANDEZ, Javier and VELAZQUEZ, Carlos} }
APA ALDAY, E , URIBE, L , VALENCIA, D , GARIBAY-ESCOBAR, A , PICCINELLI, A , RASTRELLI, L , ASTIAZARÁN-GARCÍA, H , ROBLES-ZEPEDA, R , HERNANDEZ, J , VELAZQUEZ, C . (2018). Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones. Journal of Apitherapy and Nature, 1 (3), 15-15. Retrieved from http://dergipark.org.tr/jan/issue/40577/488597
MLA ALDAY, E , URIBE, L , VALENCIA, D , GARIBAY-ESCOBAR, A , PICCINELLI, A , RASTRELLI, L , ASTIAZARÁN-GARCÍA, H , ROBLES-ZEPEDA, R , HERNANDEZ, J , VELAZQUEZ, C . "Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones". Journal of Apitherapy and Nature 1 (2018): 15-15 <http://dergipark.org.tr/jan/issue/40577/488597>
Chicago ALDAY, E , URIBE, L , VALENCIA, D , GARIBAY-ESCOBAR, A , PICCINELLI, A , RASTRELLI, L , ASTIAZARÁN-GARCÍA, H , ROBLES-ZEPEDA, R , HERNANDEZ, J , VELAZQUEZ, C . "Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones". Journal of Apitherapy and Nature 1 (2018): 15-15
RIS TY - JOUR T1 - Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones AU - Efrain ALDAY , Lucía URIBE , Dora VALENCIA , Adriana GARIBAY-ESCOBAR , Anna Lisa PICCINELLI , Luca RASTRELLI , Humberto ASTIAZARÁN-GARCÍA , Ramón Enrique ROBLES-ZEPEDA , Javier HERNANDEZ , Carlos VELAZQUEZ Y1 - 2018 PY - 2018 N1 - DO - T2 - Journal of Apitherapy and Nature JF - Journal JO - JOR SP - 15 EP - 15 VL - 1 IS - 3 SN - -2667-4734 M3 - UR - Y2 - 2019 ER -
EndNote %0 Journal of Apitherapy and Nature Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones %A Efrain ALDAY , Lucía URIBE , Dora VALENCIA , Adriana GARIBAY-ESCOBAR , Anna Lisa PICCINELLI , Luca RASTRELLI , Humberto ASTIAZARÁN-GARCÍA , Ramón Enrique ROBLES-ZEPEDA , Javier HERNANDEZ , Carlos VELAZQUEZ %T Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones %D 2018 %J Journal of Apitherapy and Nature %P -2667-4734 %V 1 %N 3 %R %U
ISNAD ALDAY, Efrain , URIBE, Lucía , VALENCIA, Dora , GARIBAY-ESCOBAR, Adriana , PICCINELLI, Anna Lisa , RASTRELLI, Luca , ASTIAZARÁN-GARCÍA, Humberto , ROBLES-ZEPEDA, Ramón Enrique , HERNANDEZ, Javier , VELAZQUEZ, Carlos . "Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones". Journal of Apitherapy and Nature 1 / 3 (December 2018): 15-15.