Year 2018, Volume 1, Issue 3, Pages 43 - 43 2018-12-08

Water Extract of Propolis Might be Safer to Use During Pregnancy than Ethanol Extract

Al Mukhlas FIKRI [1] , Ahmad SULAEMAN [2] , Sri Anna MARLIYATI [3] , Mokhamad FAHRUDIN [4]

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Propolis is a natural product that has many health benefits. This study was the first investigation examining the effect of propolis administration on pregnancy. Pregnant mice were used as experimental animals (n = 25) divided in five groups. They were control group (Tween 80 1%), low (380 mg/ kg b.w) and high (1400 mg/ kg b.w) dose of ethanol extract of propolis (EEP), low (380 mg/ kg b.w) and high (1400 mg/kg b.w) dose of water extract of propolis (WEP). Propolis was administered from 0 to 18 days of gestational age. The results showed that high dose of EEP significantly reduced weight and crown-rump of fetuses and increased the amount of resorption (p<0.05). However, low dose of EEP, low and high dose of WEP did not affect weight and crown-rump length of fetuses compare to control group. Low dose of EEP, low and high dose of WEP significantly reduced number of resorption compare to high dose of EEP. There was no difference in liver and kidney weight, serum ureum, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and maternal weight gain. No significant difference also was found in placental weight, litter size, number of dead fetuses, embryo mortality before and after implantation. The results of this study indicate that WEP might be safer to use during pregnancy than EEP.

Acknowledgement: Thanks to Ministry of Research, Technology and Higher Education, Republic of Indonesia for research grant through scheme Master and Doctoral Program of Excellent Graduate

Water Extract, Ethanol Extract, Propolis
  • 1. Fikri AM, Sulaeman A, Marliyati SA, Fahrudin M. Antiemetic Activity of Trigona spp. Propolis from Three Provinces of Indonesia with Two Methods of Extraction. Pharmacog J. 2018;10(1):120-2.
Primary Language en
Subjects
Journal Section 2nd Propolis Conference Special Issue
Authors

Author: Al Mukhlas FIKRI

Author: Ahmad SULAEMAN

Author: Sri Anna MARLIYATI

Author: Mokhamad FAHRUDIN

Bibtex @conference paper { jan489449, journal = {Journal of Apitherapy and Nature}, issn = {}, eissn = {2667-4734}, address = {Oktay YILDIZ}, year = {2018}, volume = {1}, pages = {43 - 43}, doi = {}, title = {Water Extract of Propolis Might be Safer to Use During Pregnancy than Ethanol Extract}, key = {cite}, author = {FIKRI, Al Mukhlas and SULAEMAN, Ahmad and MARLIYATI, Sri Anna and FAHRUDIN, Mokhamad} }
APA FIKRI, A , SULAEMAN, A , MARLIYATI, S , FAHRUDIN, M . (2018). Water Extract of Propolis Might be Safer to Use During Pregnancy than Ethanol Extract. Journal of Apitherapy and Nature, 1 (3), 43-43. Retrieved from http://dergipark.org.tr/jan/issue/40577/489449
MLA FIKRI, A , SULAEMAN, A , MARLIYATI, S , FAHRUDIN, M . "Water Extract of Propolis Might be Safer to Use During Pregnancy than Ethanol Extract". Journal of Apitherapy and Nature 1 (2018): 43-43 <http://dergipark.org.tr/jan/issue/40577/489449>
Chicago FIKRI, A , SULAEMAN, A , MARLIYATI, S , FAHRUDIN, M . "Water Extract of Propolis Might be Safer to Use During Pregnancy than Ethanol Extract". Journal of Apitherapy and Nature 1 (2018): 43-43
RIS TY - JOUR T1 - Water Extract of Propolis Might be Safer to Use During Pregnancy than Ethanol Extract AU - Al Mukhlas FIKRI , Ahmad SULAEMAN , Sri Anna MARLIYATI , Mokhamad FAHRUDIN Y1 - 2018 PY - 2018 N1 - DO - T2 - Journal of Apitherapy and Nature JF - Journal JO - JOR SP - 43 EP - 43 VL - 1 IS - 3 SN - -2667-4734 M3 - UR - Y2 - 2019 ER -
EndNote %0 Journal of Apitherapy and Nature Water Extract of Propolis Might be Safer to Use During Pregnancy than Ethanol Extract %A Al Mukhlas FIKRI , Ahmad SULAEMAN , Sri Anna MARLIYATI , Mokhamad FAHRUDIN %T Water Extract of Propolis Might be Safer to Use During Pregnancy than Ethanol Extract %D 2018 %J Journal of Apitherapy and Nature %P -2667-4734 %V 1 %N 3 %R %U
ISNAD FIKRI, Al Mukhlas , SULAEMAN, Ahmad , MARLIYATI, Sri Anna , FAHRUDIN, Mokhamad . "Water Extract of Propolis Might be Safer to Use During Pregnancy than Ethanol Extract". Journal of Apitherapy and Nature 1 / 3 (December 2018): 43-43.