BibTex RIS Kaynak Göster

Total antioxidant capacity, total oxidant level and oxidative stress index in patients with laryngopharyngeal reflux with Helicobacter pylori IGG positivity

Yıl 2013, Cilt: 3 Sayı: 1, 25 - 30, 01.03.2013
https://doi.org/10.2399/jmu.2013001009

Öz

Objective: The aim of this study is to investigated the relationship between H. pylori IgG positivity, total antioxidant capacity (TAC), total oxidant level (TOL) and oxidative stress index (OSI) in patients with laryngopharyngeal reflux (LPR). Methods: A total of 48 patients with laryngopharyngeal reflux (LPR) were included into the study group. Of these patients, 20 with H. pylori IgG (-), LPR (+) were included into Group 2; and 28 patients with H. pylori IgG (+), LPR (+) were included into Group 3. The control group (Group 1) consisted of 19 healthy subjects. In all groups, total antioxidant capacity, total oxidant level and oxidative stress index were studied. Results: Group 3's total oxidant level values were significantly higher than those of Group 1 (p=0.000) and Group 2 (p=0.000); and Group 2's total oxidant level values were significantly higher than Group 1. Group 3's oxidative stress index values were significantly higher than those of Group 1 (p=0.000) and Group 2 (p=0.000), and Group 2's oxidative stress index values were significantly higher than Group 1 (p=0.001). Conclusion: The presence of LFR alone, or LFR and increase in the level of serum IgG antibody developed against H. pylori, lead to increase in total oxidant level and oxidative stress index. Both LPR and to be infected with H. pylori and development of H. pylori IgG antibodies lead to an increase in total oxidant level and oxidative stress index; and an increase in free radicals ultimately lead to an increase in oxidative stress in the body.

Kaynakça

  • Cave DR. Transmission and epidemiology of Helicobacter pylori. Am J Med 1996;100:12-7.
  • Wyle FA. Helicobacter pylori: current perspectives. J Clin Gastroenterol 1991;13:114-24.
  • Goodwin CS, Worsley BW. Microbiology of Helicobacter pylori. Gastroenterol Clin North Am 1993;22:5-19.
  • Dunn Be, Cohen H, Blaser MJ. Helicobacter pylori. Clin Microbiol Rev 1997;10:720-41.
  • Megraud F. Epidemiology of Helicobacter pylori infection. Gastroenterol Clin North Am 1993;22:73-88.
  • Perinondi Nl, Thomson W, Schmid Hho. Diabetic heart and kidney exhibit creased resistance to lipid peroxidation. Biochim Biophys Acta 1990;1047:63-9.
  • Freeman BA, Crapo JD. Biology of disease free radicals and tis- sue injury. Lab Invest 1982;47:412-426.
  • Graham DY. Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model. Gastroenterology 1997:113:1983-91.
  • Rowland M, Drumm B. Clinical significance of Helicobacter pylori infection in children. Br Med Bull 1998;54:95-103.
  • Emst P. Review article: the role of infiammation in the patho genesis of gastric cancer. Alim Pharmacol Therapeut 1999;13: 13-8.
  • Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. 3rd ed. Oxford: Oxford Science Publications; 1999.
  • Mainie I, Tutuian R, Castell DO. Comparison between the com- bined analysis and the DeMeester Score to predict response to PPI therapy. J Clin Gastroenterol 2006;40:602-5.
  • Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004;37:112-9.
  • Erel O. A new automated colorimetric method for measuring total oxidant status. J Clin Biochem 2005;47:119-29.
  • Harma M, Harma M, Kocyigit A, Erel O. Increased DNA dam- age in patients with complete hydatidiform mole. Mutat Res 2005;583:49-54.
  • Jaund AF; Role of free radicals in cancer development. Eur J Cancer 1996;32:30-38
  • Yang MH, Schaich KM. Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes. Free Radic Biol Med 1996;20:225-36.
  • Salin ML, Mccoard JM. Free radical and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase. J Clin Invest 1975;56:1319-23.
  • Burton G, Traber M. Antioxidants action of carotenoids. J Nutr 1989;119:109-11.
  • Harris PR, Mobley HLT, Perez-Perez GI, Blaser MJ, Smith PD. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production. Gastroenterology 1996;111:419-25.
  • Figura N. Are Helicobacter pylori differences important in the development of Helicobacter pylori-related diseases? Ital J Gastroenterol Hepatol 1997;29:367-74.
  • Langton SR, Cesareo SD. Helicobacter pylori associated phospho- lipase A2 activity: a factor in peptic ulceration. J Clin Pathol 1992;45:221-4.
  • Ernst PB, Pecquet S. Interaction between Helicobacter pylori and the local mucosal immune system. Scand J Gastroenterol Suppl 1991;187:56-64.
  • Buommino E, Donnarumma G, Manente L, et al. The Helicobacter pylori protein HspB interferes with Nrf2/Keap1 pathway altering the antioxidant response of Ags cells. Helicobacter 2012;17:417- 25.
  • Cekin E, Ozyurt M, Erkul E, et al. The association between Helicobacter pylori and laryngopharyngeal reflux in laryngeal pathologies. Ear Nose Throat J 2012;91:E6-9.
  • Bu açık eriflim makalenin, ticari kullanım amacı ve içerik de¤iflikli¤i dıflında kalan ço¤altma, da¤ıtma vb. tüm kullanım hakları, bilinen standartlarda kay
  • nak olarak gösterilmesi kofluluyla Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND3.0) Lisansı aracılı¤ıyla
  • (http://creativecommons.org/licenses/by-nc-nd/3.0/) bedelsiz kullanıma sunulmufltur.
  • Makalenin atıf künyesi: Mutlu Ö, Kar M, Yıldız Zeyrek F, Aksoy N, Taflkın A. Helicobacter pylori serum IGG’si pozitif olan larengofarengeal reflülü olgu
  • larda total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi. J Med Updates 2013;3(1):25-30.

Helicobacter pylori serum IGG'si pozitif olan larengofarengeal reflülü olgularda total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi

Yıl 2013, Cilt: 3 Sayı: 1, 25 - 30, 01.03.2013
https://doi.org/10.2399/jmu.2013001009

Öz

Amaç: Bu çalışmanın amacı, larengofarengeal reflü (LFR) hastalarında, H. pylori serum IgG pozitifliği, total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi arasındaki ilişkiyi araştırmaktır. Yöntem: Larengofarengeal reflü (LFR) şikayeti ile başvuran 48 hasta çalışma grubuna alınmıştır. Bu hastalardan, H. pylori IgG (-), LFR (+) olan 20 hasta Grup 2 ve H. pylori IgG (+), LFR (+) olan 28 hasta Grup 3 olarak çalışmaya alınmıştır. Kontrol grubunu (Grup 1) ise, 19 sağlıklı birey oluşturmuştur. Tüm gruplarda, total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi çalışılmıştır. Bulgular: Grup 3'ün total oksidan seviye değerleri, Grup 1 (p=0.000) ve Grup 2'den (p=0.000) ve Grup 2'nin total oksidan seviye değerleri ise, Grup 1'den istatistiksel olarak anlamlı şekilde daha yüksekti. Grup 3'ün oksidatif stres indeksi değerleri, Grup 1 (p=0.000) ve Grup 2'den (p=0.000), Grup 2'nin oksidatif stres indeksi değerleri, Grup 1'den (p=0.001) istatistiksel olarak anlamlı şekilde daha yüksekti. Sonuç: Tek başına LFR varlığı veya LFR ve H. pylori'ye karşı gelişen serum IgG antikor seviyesindeki artış, total oksidan seviye ve oksidatif stres indeksinde artmaya yol açmaktadır. Hem LFR hem de H. pylori ile enfekte olunması ve H. pylori'ye karşı IgG antikorlarının gelişmesi, vücutta total oksidan seviye ve oksidatif stres indeksinde artışa yol açarak, sonuçta serbest radikallerde artışa ve vücutta oksidatif streste artışa yol açmaktadır.

Kaynakça

  • Cave DR. Transmission and epidemiology of Helicobacter pylori. Am J Med 1996;100:12-7.
  • Wyle FA. Helicobacter pylori: current perspectives. J Clin Gastroenterol 1991;13:114-24.
  • Goodwin CS, Worsley BW. Microbiology of Helicobacter pylori. Gastroenterol Clin North Am 1993;22:5-19.
  • Dunn Be, Cohen H, Blaser MJ. Helicobacter pylori. Clin Microbiol Rev 1997;10:720-41.
  • Megraud F. Epidemiology of Helicobacter pylori infection. Gastroenterol Clin North Am 1993;22:73-88.
  • Perinondi Nl, Thomson W, Schmid Hho. Diabetic heart and kidney exhibit creased resistance to lipid peroxidation. Biochim Biophys Acta 1990;1047:63-9.
  • Freeman BA, Crapo JD. Biology of disease free radicals and tis- sue injury. Lab Invest 1982;47:412-426.
  • Graham DY. Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model. Gastroenterology 1997:113:1983-91.
  • Rowland M, Drumm B. Clinical significance of Helicobacter pylori infection in children. Br Med Bull 1998;54:95-103.
  • Emst P. Review article: the role of infiammation in the patho genesis of gastric cancer. Alim Pharmacol Therapeut 1999;13: 13-8.
  • Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. 3rd ed. Oxford: Oxford Science Publications; 1999.
  • Mainie I, Tutuian R, Castell DO. Comparison between the com- bined analysis and the DeMeester Score to predict response to PPI therapy. J Clin Gastroenterol 2006;40:602-5.
  • Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004;37:112-9.
  • Erel O. A new automated colorimetric method for measuring total oxidant status. J Clin Biochem 2005;47:119-29.
  • Harma M, Harma M, Kocyigit A, Erel O. Increased DNA dam- age in patients with complete hydatidiform mole. Mutat Res 2005;583:49-54.
  • Jaund AF; Role of free radicals in cancer development. Eur J Cancer 1996;32:30-38
  • Yang MH, Schaich KM. Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes. Free Radic Biol Med 1996;20:225-36.
  • Salin ML, Mccoard JM. Free radical and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase. J Clin Invest 1975;56:1319-23.
  • Burton G, Traber M. Antioxidants action of carotenoids. J Nutr 1989;119:109-11.
  • Harris PR, Mobley HLT, Perez-Perez GI, Blaser MJ, Smith PD. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production. Gastroenterology 1996;111:419-25.
  • Figura N. Are Helicobacter pylori differences important in the development of Helicobacter pylori-related diseases? Ital J Gastroenterol Hepatol 1997;29:367-74.
  • Langton SR, Cesareo SD. Helicobacter pylori associated phospho- lipase A2 activity: a factor in peptic ulceration. J Clin Pathol 1992;45:221-4.
  • Ernst PB, Pecquet S. Interaction between Helicobacter pylori and the local mucosal immune system. Scand J Gastroenterol Suppl 1991;187:56-64.
  • Buommino E, Donnarumma G, Manente L, et al. The Helicobacter pylori protein HspB interferes with Nrf2/Keap1 pathway altering the antioxidant response of Ags cells. Helicobacter 2012;17:417- 25.
  • Cekin E, Ozyurt M, Erkul E, et al. The association between Helicobacter pylori and laryngopharyngeal reflux in laryngeal pathologies. Ear Nose Throat J 2012;91:E6-9.
  • Bu açık eriflim makalenin, ticari kullanım amacı ve içerik de¤iflikli¤i dıflında kalan ço¤altma, da¤ıtma vb. tüm kullanım hakları, bilinen standartlarda kay
  • nak olarak gösterilmesi kofluluyla Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND3.0) Lisansı aracılı¤ıyla
  • (http://creativecommons.org/licenses/by-nc-nd/3.0/) bedelsiz kullanıma sunulmufltur.
  • Makalenin atıf künyesi: Mutlu Ö, Kar M, Yıldız Zeyrek F, Aksoy N, Taflkın A. Helicobacter pylori serum IGG’si pozitif olan larengofarengeal reflülü olgu
  • larda total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi. J Med Updates 2013;3(1):25-30.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Önder Mutlu Bu kişi benim

Murat Kar Bu kişi benim

Fadile Yıldız Zeyrek Bu kişi benim

Nurten Aksoy Bu kişi benim

Abdullah Taşkın Bu kişi benim

Yayımlanma Tarihi 1 Mart 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 3 Sayı: 1

Kaynak Göster

APA Mutlu, Ö., Kar, M., Zeyrek, F. Y., Aksoy, N., vd. (2013). Helicobacter pylori serum IGG’si pozitif olan larengofarengeal reflülü olgularda total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi. Journal of Medical Updates, 3(1), 25-30. https://doi.org/10.2399/jmu.2013001009
AMA Mutlu Ö, Kar M, Zeyrek FY, Aksoy N, Taşkın A. Helicobacter pylori serum IGG’si pozitif olan larengofarengeal reflülü olgularda total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi. Journal of Medical Updates. Mart 2013;3(1):25-30. doi:10.2399/jmu.2013001009
Chicago Mutlu, Önder, Murat Kar, Fadile Yıldız Zeyrek, Nurten Aksoy, ve Abdullah Taşkın. “Helicobacter Pylori Serum IGG’si Pozitif Olan Larengofarengeal reflülü Olgularda Total Antioksidan Kapasite, Total Oksidan Seviye Ve Oksidatif Stres Indeksi”. Journal of Medical Updates 3, sy. 1 (Mart 2013): 25-30. https://doi.org/10.2399/jmu.2013001009.
EndNote Mutlu Ö, Kar M, Zeyrek FY, Aksoy N, Taşkın A (01 Mart 2013) Helicobacter pylori serum IGG’si pozitif olan larengofarengeal reflülü olgularda total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi. Journal of Medical Updates 3 1 25–30.
IEEE Ö. Mutlu, M. Kar, F. Y. Zeyrek, N. Aksoy, ve A. Taşkın, “Helicobacter pylori serum IGG’si pozitif olan larengofarengeal reflülü olgularda total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi”, Journal of Medical Updates, c. 3, sy. 1, ss. 25–30, 2013, doi: 10.2399/jmu.2013001009.
ISNAD Mutlu, Önder vd. “Helicobacter Pylori Serum IGG’si Pozitif Olan Larengofarengeal reflülü Olgularda Total Antioksidan Kapasite, Total Oksidan Seviye Ve Oksidatif Stres Indeksi”. Journal of Medical Updates 3/1 (Mart 2013), 25-30. https://doi.org/10.2399/jmu.2013001009.
JAMA Mutlu Ö, Kar M, Zeyrek FY, Aksoy N, Taşkın A. Helicobacter pylori serum IGG’si pozitif olan larengofarengeal reflülü olgularda total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi. Journal of Medical Updates. 2013;3:25–30.
MLA Mutlu, Önder vd. “Helicobacter Pylori Serum IGG’si Pozitif Olan Larengofarengeal reflülü Olgularda Total Antioksidan Kapasite, Total Oksidan Seviye Ve Oksidatif Stres Indeksi”. Journal of Medical Updates, c. 3, sy. 1, 2013, ss. 25-30, doi:10.2399/jmu.2013001009.
Vancouver Mutlu Ö, Kar M, Zeyrek FY, Aksoy N, Taşkın A. Helicobacter pylori serum IGG’si pozitif olan larengofarengeal reflülü olgularda total antioksidan kapasite, total oksidan seviye ve oksidatif stres indeksi. Journal of Medical Updates. 2013;3(1):25-30.