Year 2019, Volume 3, Issue 1, Pages 4 - 7 2019-01-27

Nötrofil/lenfosit oranı ve platelet/lenfosit oranı non-dipper kan basıncı için biyobelirteç olarak kullanılabilir mi?
Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure?

Özge Turgay Yıldırım [1] , Ercan Akşit [2] , Fatih Aydın [3] , Ayse Hüseyinoglu Aydın [4] , Evrin Dağtekin [5]

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Amaç: Hipertansiyon, kardiyovasküler hastalıklar için önemli bir risk faktörüdür ve non-dipper kan basıncı kardiyovasküler olaylar için artmış risk ile ilişkilidir. Nötrofil lenfosit oranı (NLR) ve platelet lenfosit oranı (PLR) inflamasyon ve kardiyovasküler risk ile ilişkilidir. Bu çalışmanın amacı, hipertansif ve normotansif hastalarda NLR, PLR ve non-dipper kan basıncı arasındaki ilişkiyi araştırmaktır.

Yöntemler: Çalışmaya toplam 482 hasta alındı. Çalışma retrospektif kohort çalışma olarak planlandı. 24 saatlik ayaktan kan basıncı monitorizasyonu sonuçlarına göre dört grup oluşturuldu. Grup 1 hipertansif, non-dipper hastalar, Grup 2 hipertansif, dipper hastalar; Grup 3 normotansif, non-dipper hastalar ve Grup 4 normotansif, dipper hastalar olarak sınıflandırıldı.

Bulgular: Çalışma popülasyonunun yaş ortalaması 50,1±15,5 yıl idi ve %38,1'i erkekti. Grup 1 (n = 165), Grup 2 (n=88), Grup 3 (n=123) ve Grup 4 (n=91) NLR açısından karşılaştırıldığında sonuç istatistiksel olarak anlamlı farklıydı (p<0,001). Grup 1'de; Grup 2'ye (p=0,001), Grup 3'e (p=0,002) ve Grup 4'e (p=0,023) göre NLR değeri istatistiksel anlamlı yüksekti. Hipertansif hasta grubunda, Grup 1'in PLR değerleri Grup 2'den anlamlı olarak yüksekti (p=0,002). Pearson korelasyon analizine göre NLR ve PLR, diurnal kan basıncı değişkenliği ile korelasyon gösterdi (NLR için r=-0,188, p<0,001 ve PLR için r =-0,182, p<0,001). Regresyon analizinde NLR (p=0,040), PLR (p=0,021), yaş (p=0,006) ve hipertansiyon (p<0,001), kan basıncı değişkenliğinin bağımsız belirleyicileri olarak saptandı.

Sonuç: Bulgularımız, NLR ve PLR'nin hipertansif hastalarda non-dipper kan basıncı için ucuz ve kolay erişilebilir işaretleyiciler olarak kullanılabileceğini göstermektedir.

Aim: Hypertension is a major risk factor for cardiovascular diseases and non-dipper status is associated with increased risk for cardiovascular events. Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are related to inflammation and cardiovascular risk. The purpose of the study is to investigate the relationship between NLR and PLR with non-dipper status of hypertensive and normotensive patients.  

Methods:  A total of 482 patients were enrolled for the study. The study was planned as retrospective cohort study. Four groups were formed according to 24-h ambulatory blood pressure monitoring results. Group 1 was defined as hypertensive, non-dipper patients; group 2 as hypertensive, dipper patients; group 3 as normotensive, non-dipper patients and group 4 as normotensive, dipper patients.

Results: Mean age of the study population was 50.1±15.5 years, 38.1% were male. According to the statistical analysis of Group 1 (n=165), Group 2 (n=88), Group 3 (n=123) and Group 4 (n=91) NLR was statistically different among groups (p<0.001). Group 1 had significantly higher values compared to Group 2 (p=0.001), Group 3 (p=0.002) and Group 4 (p=0.023). In hypertensive patient group, PLR values of Group 1 was significantly higher than Group 2 (p=0.002). Pearson correlation analysis showed that NLR and PLR were correlated with BP variability (r=-0.188, p<0.001 for NLR and r=-0.182 and p<0.001 for PLR). Regression analysis showed NLR (p=0.040), PLR (p=0.021), age (p=0.006) and hypertension (p<0.001) were independent predictors of BP variability.

Conclusion: Our findings suggest that NLR and PLR can be used as inexpensive and easily accessible markers to detect non-dipper status in hypertensive patients.


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Primary Language en
Subjects General and Internal Medicine
Journal Section Research article
Authors

Orcid: 0000-0002-6731-4958
Author: Özge Turgay Yıldırım (Primary Author)
Institution: Eskisehir State Hospital Cardiology Department
Country: Turkey


Author: Ercan Akşit
Institution: Canakkale Onsekiz Mart University Cardiology Department
Country: Turkey


Author: Fatih Aydın
Institution: Eskisehir State Hospital Cardiology Department
Country: Turkey


Author: Ayse Hüseyinoglu Aydın
Institution: Eskisehir State Hospital Cardiology Department
Country: Turkey


Author: Evrin Dağtekin
Institution: Eskisehir State Hospital Cardiology Department
Country: Turkey


Dates

Publication Date: January 27, 2019

Bibtex @research article { josam436951, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {Fatih BAŞAK}, year = {2019}, volume = {3}, pages = {4 - 7}, doi = {10.28982/josam.436951}, title = {Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure?}, key = {cite}, author = {Turgay Yıldırım, Özge and Akşit, Ercan and Aydın, Fatih and Hüseyinoglu Aydın, Ayse and Dağtekin, Evrin} }
APA Turgay Yıldırım, Ö , Akşit, E , Aydın, F , Hüseyinoglu Aydın, A , Dağtekin, E . (2019). Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure?. Journal of Surgery and Medicine, 3 (1), 4-7. DOI: 10.28982/josam.436951
MLA Turgay Yıldırım, Ö , Akşit, E , Aydın, F , Hüseyinoglu Aydın, A , Dağtekin, E . "Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure?". Journal of Surgery and Medicine 3 (2019): 4-7 <http://dergipark.org.tr/josam/issue/42845/436951>
Chicago Turgay Yıldırım, Ö , Akşit, E , Aydın, F , Hüseyinoglu Aydın, A , Dağtekin, E . "Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure?". Journal of Surgery and Medicine 3 (2019): 4-7
RIS TY - JOUR T1 - Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure? AU - Özge Turgay Yıldırım , Ercan Akşit , Fatih Aydın , Ayse Hüseyinoglu Aydın , Evrin Dağtekin Y1 - 2019 PY - 2019 N1 - doi: 10.28982/josam.436951 DO - 10.28982/josam.436951 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 4 EP - 7 VL - 3 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.436951 UR - https://doi.org/10.28982/josam.436951 Y2 - 2018 ER -
EndNote %0 Journal of Surgery and Medicine Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure? %A Özge Turgay Yıldırım , Ercan Akşit , Fatih Aydın , Ayse Hüseyinoglu Aydın , Evrin Dağtekin %T Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure? %D 2019 %J Journal of Surgery and Medicine %P -2602-2079 %V 3 %N 1 %R doi: 10.28982/josam.436951 %U 10.28982/josam.436951
ISNAD Turgay Yıldırım, Özge , Akşit, Ercan , Aydın, Fatih , Hüseyinoglu Aydın, Ayse , Dağtekin, Evrin . "Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure?". Journal of Surgery and Medicine 3 / 1 (January 2019): 4-7. https://doi.org/10.28982/josam.436951
AMA Turgay Yıldırım Ö , Akşit E , Aydın F , Hüseyinoglu Aydın A , Dağtekin E . Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure?. J Surg Med. 2019; 3(1): 4-7.
Vancouver Turgay Yıldırım Ö , Akşit E , Aydın F , Hüseyinoglu Aydın A , Dağtekin E . Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure?. Journal of Surgery and Medicine. 2019; 3(1): 7-4.