Year 2019, Volume 3, Issue 1, Pages 39 - 43 2019-01-27

Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study
Total kalça protez ameliyatlarında yüksek doz traneksamik asitin etkileri: Prospektif, çift-kör, randomize kontrollü çalışma

Seher Orbay Yaşlı [1] , Zeynep Tosun [2] , Mehmet Halıcı [3] , Selda Kahraman Kayaaltı [4]

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Aim: Different studies support the use of tranexamic acid (TA) to decrease the rate of transfusions in total hip replacement. This study aimed to investigate the effects of high-dose TA in total hip replacement.

Methods: Sixty American Society of Anesthesiologist (ASA) class I-III 60 adult patients were randomly assigned into 2 groups as group TA and group control (C) for this study. While, TA was administered at dose of 50 mg/kg to group TA, the group C received 100 cc normal saline (NS). In all subjects, blood samples were taken pre-surgery and 24 hours after the operation in order to study hemoglobin (Hgb), hematocrit (Hct), platelet count, prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen, D-dimer, blood urea nitrogen (BUN), creatinine, and cystatin-c. The amount of intraoperative bleeding and number of given packed of red blood cell (PRBCs) were recorded.

Results: The amount of blood loss and number of PRBCs given were significantly lower, and Hgb values at discharge were significantly higher in group TA compared with group C. In group TA postoperative cystatin-c levels, compared with the preoperative period, were significantly low. The length of hospital stay was significantly short in group TA.

Conclusion: TA was given intravenously before incision reduces intraoperative blood loss and the use of PRBCs in total hip replacement. This approach also provided higher Hgb values at discharge. The provision of TA shortened length of hospital stay and did not negatively affect renal function.


Amaç: Farklı çalışmalar total kalça protezi ameliyatlarında transfüzyon oranını azaltmak için traneksamik asit (TA) kullanımını desteklemektedir. Bu çalışmada total kalça protezi ameliyatında yüksek doz TA'nın etkilerinin araştırılması amaçlanmıştır.

Yöntemler: Bu çalışma için American Society of Anesthesiologist(ASA) sınıf I-III 60 yetişkin hasta, grup TA ve grup kontrol (C) olarak 2 gruba ayrıldı. TA grubuna 50 mg / kg’dan traneksamik asit, kontrol grubu (C grubu) hastalarına ise 100 cc normal salin (NS) uygulandı. Tüm olgularda hemoglobin(Hgb), hematocrit(Hct), trombosit sayısı, protrombin zamanı(PT), parsiyel tromboplastin zamanı(PTT), fibrinojen, D-dimer, kan üre azotu(BUN), kreatinin ve sistatin-c değerlerinin çalışılması için hastalardan operasyondan 24 saat önce ve sonra kan örnekleri alındı. İntraoperatif kanama miktarları, transfüze edilen eritrosit süspansiyonu (PRBC) sayısı kaydedildi.

Bulgular: Grup TA’da kan kaybı miktarı verilmiş olan eritrosit süspansiyonu sayısı grup C’ye göre istatistiksel olarak anlamlı düşük bulundu. Taburculuktaki hemoglobin değerleri grup TA’da grup C’ye göre istatistiksel olarak anlamlı yüksek bulundu. TA grubunun postoperatif sistatin-c değerleri preoperatif periyottaki değerlerinden istatistiksel olarak anlamlı düşük bulundu. TA grubunun hastanede kalış süreleri istatistiksel anlamlı olarak düşük bulundu.

Sonuç: Total kalça protezi ameliyatlarında insizyondan önce uygulanan 50 mg/kg traneksamik asit intraoperatif kan kaybı miktarını ve verilen eritrosit süspansiyon sayısını azaltır. Aynı zamanda bu yaklaşımla taburculukta daha yüksek hemoglobin değerleri sağlanır. Bu prosedür böbrek fonksiyonlarını etkilemediği gibi hastanede kalış sürelerinin de kısalmasına neden olur.


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Primary Language en
Subjects Medicine
Journal Section Research article
Authors

Author: Seher Orbay Yaşlı (Primary Author)
Institution: ERCİYES ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ
Country: Turkey


Author: Zeynep Tosun
Institution: ERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİ
Country: Turkey


Author: Mehmet Halıcı
Institution: ERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİ
Country: Turkey


Author: Selda Kahraman Kayaaltı
Institution: Develi Devlet Hastanesi / Kayseri
Country: Turkey


Dates

Publication Date: January 27, 2019

Bibtex @research article { josam441116, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {Fatih BAŞAK}, year = {2019}, volume = {3}, pages = {39 - 43}, doi = {10.28982/josam.441116}, title = {Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study}, key = {cite}, author = {Orbay Yaşlı, Seher and Tosun, Zeynep and Halıcı, Mehmet and Kahraman Kayaaltı, Selda} }
APA Orbay Yaşlı, S , Tosun, Z , Halıcı, M , Kahraman Kayaaltı, S . (2019). Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study. Journal of Surgery and Medicine, 3 (1), 39-43. DOI: 10.28982/josam.441116
MLA Orbay Yaşlı, S , Tosun, Z , Halıcı, M , Kahraman Kayaaltı, S . "Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study". Journal of Surgery and Medicine 3 (2019): 39-43 <http://dergipark.org.tr/josam/issue/42845/441116>
Chicago Orbay Yaşlı, S , Tosun, Z , Halıcı, M , Kahraman Kayaaltı, S . "Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study". Journal of Surgery and Medicine 3 (2019): 39-43
RIS TY - JOUR T1 - Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study AU - Seher Orbay Yaşlı , Zeynep Tosun , Mehmet Halıcı , Selda Kahraman Kayaaltı Y1 - 2019 PY - 2019 N1 - doi: 10.28982/josam.441116 DO - 10.28982/josam.441116 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 39 EP - 43 VL - 3 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.441116 UR - https://doi.org/10.28982/josam.441116 Y2 - 2018 ER -
EndNote %0 Journal of Surgery and Medicine Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study %A Seher Orbay Yaşlı , Zeynep Tosun , Mehmet Halıcı , Selda Kahraman Kayaaltı %T Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study %D 2019 %J Journal of Surgery and Medicine %P -2602-2079 %V 3 %N 1 %R doi: 10.28982/josam.441116 %U 10.28982/josam.441116
ISNAD Orbay Yaşlı, Seher , Tosun, Zeynep , Halıcı, Mehmet , Kahraman Kayaaltı, Selda . "Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study". Journal of Surgery and Medicine 3 / 1 (January 2019): 39-43. https://doi.org/10.28982/josam.441116
AMA Orbay Yaşlı S , Tosun Z , Halıcı M , Kahraman Kayaaltı S . Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study. J Surg Med. 2019; 3(1): 39-43.
Vancouver Orbay Yaşlı S , Tosun Z , Halıcı M , Kahraman Kayaaltı S . Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study. Journal of Surgery and Medicine. 2019; 3(1): 43-39.