Year 2019, Volume 3, Issue 1, Pages 22 - 26 2019-01-27

Melatonin, leptin, and ghrelin levels in nurses working night shifts
Gece Vardiyasında Çalışan Hemşirelerde Melatonin, Leptin ve Grelin Düzeyleri

Sibel Söylemez [1] , Ayşe Banu Çaycı Sivri [2] , Ercan Şimşek [3] , Burçak Polat [4] , Bekir Çakır [5]

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Aim: The levels of several hormones including melatonin, leptin, and ghrelin are regulated by circadian rhythm. Deregulated hormone levels due to disruption of circadian rhythm may result in medical conditions like metabolic syndrome (MetS). The aim of this cross-sectional study was to investigate the associations among circadian rhythm, melatonin, leptin, ghrelin and metabolic syndrome by determining melatonin levels of healthy nurses who were working on night-shift for at least 3 months and of those on day-shift for at least 3 months.

Methods: Venous bloods following 8-hour fasting of 50 nurses, who were aged at 20-40 age range and whose Body Mass Index (BMI) were >25, were collected. Those working on night-shift were named as night group and the control group of the study was named as day group. From the bloods collected; melatonin, leptin and ghrelin levels were evaluated by ELISA method, insulin was evaluated by immunochemically, whereas fasting blood glucose, cholesterol, triglyceride, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were evaluated spectrophotometrically.

Results: Melatonin level was significantly lower in the night-shift group compared to the day-shift group (p=0.003). Leptin level was slightly but not significantly lower in the night-shift group (p=0.097). In contrast, ghrelin level and other biochemical parameters including triglyceride, fasting blood sugar (FBS), insulin, insulin resistance index (HOMA-IR) and cholesterol were increased in the night-shift group but these increments were not statistically significant.

Conclusion: Our results suggest that night-shift work might exhibit tendency towards MetS by disrupting circadian rhythm. 


Amaç: Melatonin, leptin ve grelin dahil olmak üzere birçok hormonun seviyeleri sirkadiyen ritim tarafından düzenlenir. Sirkadiyen ritim bozulmasına bağlı düzensiz hormon düzeyleri metabolik sendrom (MetS) gibi sorunlara neden olabilir. Bu kesitsel çalışmada, en az 3 aydır gece ve en az 3 aydır gündüz vardiyasında çalışan sağlıklı hemşirelerin melatonin düzeylerini belirleyerek, melatonin, sirkadien ritim, leptin, grelin ve metabolik sendrom ilişkisinin araştırılması amaçlanmıştır. 

Yöntemler: 20-40 yaş aralığında, Vücut Kitle İndeksi (BMI) > 25 olan 50 hemşirenin sabah 8 saatlik açlıkla venöz kanları alınmıştır. Gece nöbet tutan grup gece grubu olarak, gündüz çalışan kontrol grubu ise gündüz grubu olarak adlandırılmıştır. Alınan kanlarda melatonin, leptin ve grelin düzeyleri ELISA metodu ile, metabolik sendrom kriterlerinden olan insülin immünokimyasal olarak, açlık kan şekeri, kolesterol, trigliserid, yüksek yoğunluklu lipoprotein (HDL) ve düşük yoğunluklu lipoprotein (LDL) düzeyleri ise spektrofotometrik olarak incelenmiştir.

Bulgular: Melatonin düzeyleri gece grubunda, gündüz grubuna göre anlamlı derecede düşük bulunmuştur (p=0,003). Leptin düzeyleri gece grubunda düşük bulunmuştur ancak istatistiksel olarak anlamlı değildir (p=0,097). Aksine grelin düzeyleri ve diğer biyokimyasal parametreler olan trigliserit, açlık kan şekeri, insülin, insülin direnci ve kolesterol gece grubunda artmıştır, ancak bu artışlar istatistiksel olarak anlamlı değildir. 

Sonuç: Bulgularımız gece vardiyasında çalışmanın sırkadiyen ritmin bozularak, MetS eğiliminin artabileceğini göstermektedir.


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Primary Language en
Subjects Medicine
Journal Section Research article
Authors

Orcid: 0000-0002-5005-2277
Author: Sibel Söylemez (Primary Author)
Institution: GAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI
Country: Turkey


Author: Ayşe Banu Çaycı Sivri
Institution: GAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI
Country: Turkey


Author: Ercan Şimşek
Institution: GAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI
Country: Turkey


Author: Burçak Polat
Institution: ANKARA ATATÜRK EĞİTİM VE ARAŞTIRMA HASTANESİ, ENDOKRİNOLOJİ VE METABOLİZMA HASTALIKLARI
Country: Turkey


Author: Bekir Çakır
Institution: ANKARA ATATÜRK EĞİTİM VE ARAŞTIRMA HASTANESİ, ENDOKRİNOLOJİ VE METABOLİZMA HASTALIKLARI
Country: Turkey


Dates

Publication Date: January 27, 2019

Bibtex @research article { josam443902, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {Fatih BAŞAK}, year = {2019}, volume = {3}, pages = {22 - 26}, doi = {10.28982/josam.443902}, title = {Melatonin, leptin, and ghrelin levels in nurses working night shifts}, key = {cite}, author = {Söylemez, Sibel and Çaycı Sivri, Ayşe Banu and Şimşek, Ercan and Polat, Burçak and Çakır, Bekir} }
APA Söylemez, S , Çaycı Sivri, A , Şimşek, E , Polat, B , Çakır, B . (2019). Melatonin, leptin, and ghrelin levels in nurses working night shifts. Journal of Surgery and Medicine, 3 (1), 22-26. DOI: 10.28982/josam.443902
MLA Söylemez, S , Çaycı Sivri, A , Şimşek, E , Polat, B , Çakır, B . "Melatonin, leptin, and ghrelin levels in nurses working night shifts". Journal of Surgery and Medicine 3 (2019): 22-26 <http://dergipark.org.tr/josam/issue/42845/443902>
Chicago Söylemez, S , Çaycı Sivri, A , Şimşek, E , Polat, B , Çakır, B . "Melatonin, leptin, and ghrelin levels in nurses working night shifts". Journal of Surgery and Medicine 3 (2019): 22-26
RIS TY - JOUR T1 - Melatonin, leptin, and ghrelin levels in nurses working night shifts AU - Sibel Söylemez , Ayşe Banu Çaycı Sivri , Ercan Şimşek , Burçak Polat , Bekir Çakır Y1 - 2019 PY - 2019 N1 - doi: 10.28982/josam.443902 DO - 10.28982/josam.443902 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 22 EP - 26 VL - 3 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.443902 UR - https://doi.org/10.28982/josam.443902 Y2 - 2018 ER -
EndNote %0 Journal of Surgery and Medicine Melatonin, leptin, and ghrelin levels in nurses working night shifts %A Sibel Söylemez , Ayşe Banu Çaycı Sivri , Ercan Şimşek , Burçak Polat , Bekir Çakır %T Melatonin, leptin, and ghrelin levels in nurses working night shifts %D 2019 %J Journal of Surgery and Medicine %P -2602-2079 %V 3 %N 1 %R doi: 10.28982/josam.443902 %U 10.28982/josam.443902
ISNAD Söylemez, Sibel , Çaycı Sivri, Ayşe Banu , Şimşek, Ercan , Polat, Burçak , Çakır, Bekir . "Melatonin, leptin, and ghrelin levels in nurses working night shifts". Journal of Surgery and Medicine 3 / 1 (January 2019): 22-26. https://doi.org/10.28982/josam.443902
AMA Söylemez S , Çaycı Sivri A , Şimşek E , Polat B , Çakır B . Melatonin, leptin, and ghrelin levels in nurses working night shifts. J Surg Med. 2019; 3(1): 22-26.
Vancouver Söylemez S , Çaycı Sivri A , Şimşek E , Polat B , Çakır B . Melatonin, leptin, and ghrelin levels in nurses working night shifts. Journal of Surgery and Medicine. 2019; 3(1): 26-22.