Year 2019, Volume 3, Issue 1, Pages 100 - 102 2019-01-27

Rehabilitasyon sırasında hızlı ilerleyen tetrapleji ve bilişsel bozulma: Bir nörodejeneratif hastalık olgusu
Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease

Sevgi İkbali Afşar [1] , Oya Umit Yemişçi [2]

515 621

İnsan prion hastalıkları, prionlar olarak adlandırılan nörolitik patojen proteinlerin neden olduğu ilerleyici nörodejeneratif hastalıklardır. En yaygın insan prion hastalığı sporadik Creutzfeldt-Jakob hastalığı olup, yıllık prevalansı yaklaşık milyonda 0.5-1'dir. Semptomlar ve bulgular; hızla ilerleyen demans, ataksi, miyoklonik nöbetler, akinetik mutizm ve diğer nörolojik ve nörodavranışsal bozuklukları içerir. Creutzfeldt-Jakob hastalığının klinik spektrumu oldukça değişkendir, bu nedenle premortem teşhis etmek zor olabilir. Bu makalede, başlangıçta yürüme zorluğu ve denge bozukluğu ile başvuran 78 yaşında bir kadın hasta anlatılmaktadır. Yapılan değerlendirme sonucunda hasta servikal spinal stenoz tanısı ile rehabilitasyon kliniğine transfer edildi. Hastanede yatışı sırasında, yürüme ve dengesi progresif olarak kötüye giderek bozuldu. İleri tetkiklerden sonra hastanın olası sporadik Creutzfeldt-Jakob hastalığı olduğu düşünülmüştür.

Human prion diseases are fatal, progressive neurodegenerative disorders caused by neurolytic pathogen proteins, called prions. The most common human prion disease is sporadic Creutzfeldt-Jakob disease, with an approximate annual prevalence of 0.5-1 per million. The symptoms and signs include rapidly progressive dementia, ataxia, myoclonic seizures, akinetic mutism and other neurological and neurobehavioral disorders. The clinical spectrum of Creutzfeldt-Jakob disease is highly variable; therefore it can be difficult to diagnose premortem. This article describes a 78-year-old woman who initially presented with difficulty walking and balance disorder. As a result of the evaluation, the patient was transferred to rehabilitation clinic, with a diagnosis of cervical spinal stenosis. During hospitalization, she showed progressive decline in gait and balance and deteriorated rapidly. The patient was considered to be probable sporadic Creutzfeldt-Jakob disease after further investigations.

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Primary Language en
Subjects Medicine
Journal Section Case report
Authors

Orcid: 0000-0002-4003-3646
Author: Sevgi İkbali Afşar (Primary Author)
Institution: BAŞKENT ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-0501-5127
Author: Oya Umit Yemişçi
Institution: BAŞKENT ÜNİVERSİTESİ
Country: Turkey


Dates

Publication Date: January 27, 2019

Bibtex @case report { josam454181, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {Fatih BAŞAK}, year = {2019}, volume = {3}, pages = {100 - 102}, doi = {10.28982/josam.454181}, title = {Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease}, key = {cite}, author = {İkbali Afşar, Sevgi and Umit Yemişçi, Oya} }
APA İkbali Afşar, S , Umit Yemişçi, O . (2019). Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease. Journal of Surgery and Medicine, 3 (1), 100-102. DOI: 10.28982/josam.454181
MLA İkbali Afşar, S , Umit Yemişçi, O . "Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease". Journal of Surgery and Medicine 3 (2019): 100-102 <http://dergipark.org.tr/josam/issue/42845/454181>
Chicago İkbali Afşar, S , Umit Yemişçi, O . "Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease". Journal of Surgery and Medicine 3 (2019): 100-102
RIS TY - JOUR T1 - Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease AU - Sevgi İkbali Afşar , Oya Umit Yemişçi Y1 - 2019 PY - 2019 N1 - doi: 10.28982/josam.454181 DO - 10.28982/josam.454181 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 100 EP - 102 VL - 3 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.454181 UR - https://doi.org/10.28982/josam.454181 Y2 - 2018 ER -
EndNote %0 Journal of Surgery and Medicine Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease %A Sevgi İkbali Afşar , Oya Umit Yemişçi %T Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease %D 2019 %J Journal of Surgery and Medicine %P -2602-2079 %V 3 %N 1 %R doi: 10.28982/josam.454181 %U 10.28982/josam.454181
ISNAD İkbali Afşar, Sevgi , Umit Yemişçi, Oya . "Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease". Journal of Surgery and Medicine 3 / 1 (January 2019): 100-102. https://doi.org/10.28982/josam.454181
AMA İkbali Afşar S , Umit Yemişçi O . Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease. J Surg Med. 2019; 3(1): 100-102.
Vancouver İkbali Afşar S , Umit Yemişçi O . Rapidly progressive tetraplegia and cognitive deterioration during rehabilitation: A case of neurodegenerative disease. Journal of Surgery and Medicine. 2019; 3(1): 102-100.