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THE IMPORTANCE OF THE MEDICINAL PLANT NASTURTIUM OFFICINALE L. IN THE ANTICANCER ACTIVITY RESEARCH

Yıl 2019, Cilt: 3 Sayı: 2, 159 - 164, 30.04.2019
https://doi.org/10.26900/jsp.3.016

Öz

Cancer is known as one of the main cause of death worldwide. It is
difficult to discover novel agents that selectively kill tumor cells or inhibit
their proliferation without toxicity. 
Searching for more active and selective compounds with less toxicity is
the main target of cancer researches. Nasturtium officinale L. has been used
for a long time as a food and medicinal plant. Main therapeutic effects of this
plant are due to rich essential nutrients as well as health-promoting plant
secondary metabolites such as phenolics and glucosinolates. The plant was
repoted to have antiviral, antiinflammatory, diuretic, expectorant,
antidiabetic, hepatoprotective, antihyperlipidemic and anticancer properties.
The aim of this study is to make review about the previous reports on secondary
metabolites of Nasturtium officinale L. in terms of or their effects against
various cancer cell lines.

Kaynakça

  • [1] GIORDANO, S., PETRELLI, A., 2008, From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage, Current Medicinal Chemistry, 15, 422. [2] BARKER, D.J., 2009, Pacific Northwest Aquatic Invasive Species Profile: Nasturtium officinale (Watercress). https://depts.washington.edu/oldenlab/wordpress/wpcontent/uploads/2013/03/Nasturtium-officinale_Barker.pdf
  • [3] DOLATKHAHI, M., DOLATKHAHI, A., & NEJAD, J.B., 2014, Ethnobotanical study of medicinal plants used in Arjan- Parishan protected area in Fars Province of Iran. Avicenna journal of phytomedicine, 4(6), 402-12. [4] ANDRADE, J. M., LUCERO MOSQUERA, H., & ARMIJOS, C., 2017. Ethnobotany of Indigenous Saraguros: Medicinal Plants Used by Community Healers "Hampiyachakkuna" in the San Lucas Parish, Southern Ecuador. BioMed research international, 9343724.
  • [5] ABBASI, A.M., KHAN, M.A., SHAH, M.H., SHAH, M.M., PERVEZ, A., AHMAD, M., 2013, Ethnobotanical appraisal and cultural values of medicinally important wild edible vegetables of Lesser Himalayas-Pakistan, J. Ethnobiol. Ethnomed., 9(1), 66.
  • [6] S. AL-QURA`N.,2006. Ethnobotany of Folk Medicinal Potentiality of Aquatic Plants in Jordan. Research Journal of Botany, 1, 75-84.
  • [7] FLAVIA, L. P., JOSE, M. F., JOAO, P. V. L., 2012. Ethnopharmacological survey: a selection strategy to identify medicinal plants for a local phytotherapy program. Brazilian Journal of Pharmaceutical Sciences, 48, (2).299-313.
  • [8] FAWZI MAHOMOODALLY, M., PRIYAMKA SREEKEESOON D., 2017, A Quantitative Ethnopharmacological Documentation of Natural Pharmacological Agents Used by Pediatric Patients in Mauritius, BioMed Research International, 1-14.
  • [9] AIRES, A., CARVALHO, R., ROSA, E.A.S., SAAVEDRA M. J., 2013, Phytochemical characterization and antioxidant properties of baby-leaf watercress produced under organic production system, CyTA, Journal of Food, 11:4, 343-351.
  • [10] ZEB, A., 2015, Phenolic profile and antioxidant potential of wild watercress (Nasturtium officinale L.). SpringerPlus, 4, 714.
  • [11] HARO, G., IKSEN, I., RUMANTİ, R.M., MARBUN, N., SARİ, R.P., GULTON, R.P.J., 2018, Evoluation of Antioxidant activity and Minerals Value From Watercress (Nasturtium officinale R.Br.), 11 (1), 232-237.
  • [12] PAHWA, R., JIALAL, I., 2018, Chronic Inflammation. StatPearls Publishing LLC, Treasure Island (FL).
  • [13] BALISTRERI, C.R., CARUSO, C., CANDORE, G., 2010, The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediat Inflamm, 802078.
  • [14] LIBRA, M., NICOLETTI, F., 2017, Diet, inflammation and cancer: a journey from prevention to treatment. In: Accardi G, Caruso C, editors. Updates in pathobiology: causality and chance in ageing, age-related diseases and longevity. Palermo, University Press, 145–162.
  • [15] ACCARDI, G., CARUSO, C., 2018, Immune-inflammatory responses in the elderly: an update. Immun Ageing, 15, 1-11.
  • [16] SANTOS J, OLIVEIRA MBPP, IBÁÑEZ E, HERRERO M. 2014, Phenolic profile evolution of different ready-to-eat baby-leaf vegetables during storage. J Chromatogr A.1327:118–31.
  • [17] AIRES, A., CARVALHO, R., ROSA, EAS, SAAVEDRA, M.J. 2013, Phytochemical characterization and antioxidant properties of baby-leaf watercress produced under organic production system. CyTA- J Food., 11, 343–51.
  • [18] MARTÍNEZ-SÁNCHEZ, A., GIL-IZQUIERDO, A., GIL, M.I., FERRERES F., 2008, A comparative study of flavonoid compounds, vitamin C, and antioxidant properties of baby leaf Brassicaceae species. J Agric Food Chem., 56, 2330–2340.
  • [19] DI NOIA, J., 2014, Defining powerhouse fruits and vegetables: a nutrient density approach. Preventing chronic disease, 11, 1-5.
  • [20] HEBATOLLAH, S., MOSTAFAZADEH, M., SADEGHI, H., MNADERİAN, MEHRZAD JAFARİ BARMAK, MOHAMMAD SHARİF TALEBİANPOOR & FOUAD MEHRABAN (2014) In vivo anti-inflammatory properties of aerial parts of Nasturtium officinale, Pharmaceutical Biology, 52(2), 169-174.
  • [21] SHAHANI, S., BEHZADFAR, F., JAHANI, D., GHASEMI, M., SHAKI, F., 2017, Antioxidant and anti-inflammatory effects of Nasturtium officinale involved in attenuation of gentamicin-induced nephrotoxicity, Toxicology Mechanisms and Methods, 27(2), 107-114.
  • [22] GILL, C.I., HALDAR, S., BOYD, L.A., BENNETT, R., WHITEFORD, J., BUTLER, M., PEARSON, J.R., BRADBURY, I., ROWLAND, I.R., 2007. Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults. Am J Clin Nutr. 85, 504–510.
  • [23] LAI K.C., HSU, S.C., KUO, C.L., IP, S.W., YANG, J.S., HSU, Y.M., HUANG H.Y., WU S.H., CHUNG, J.G., 2010, Phenethyl Isothiocyanate Inhibited Tumor Migration and Invasion via Suppressing Multiple Signal Transduction Pathways in Human Colon Cancer HT29 Cells, Journal of Agricultural and Food Chemistry, 58 (20), 11148-11155.
  • [24] PEREIRA LUCÍLIA, P., SILVA P., DUARTE, M., RODRIGUES, L., DUARTE C. M. M, ALBUQUERQUE, C., TERESA SERRA, A., 2017, Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study, Nutrients, 9(4), 368.
  • [25] ROSE, P., HUANG, Q., ONG, C.N., WHITEMAN, M., 2005, Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol. 209 (2), 105-113.
  • [26] SYED ALWI, S. S., CAVELL, B. E., TELANG, U., MORRIS, M. E., PARRY, B. M., PACKHAM, G., 2010, In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study. The British journal of nutrition, 104 (9), 1288-96.
  • [27] CAVELL, B.E., SYED ALWI S.S., DONLEVY, A., PACKHAM, G., 2011, Anti-angiogenic effects of dietary isothiocyanates: mechanisms of action and implications for human health, Biochem Pharmacol. 81 (3), 327-36.
  • [28] PAN, J H., ABERNATHY, B., KIM, Y. J., LEE J. H., KIM, J. H., SHIN, E. C., KIM J. K., 2018, Cruciferous vegetables and colorectal cancer prevention through microRNA regulation: A review, Critical Reviews in Food Science and Nutrition, 58 (12), 2026-2038.
  • [29] FOGARTY, M.C., HUGHES, C.M., BURKE, G., BROWN, J.C., DAVISON, G.W., 2013, Acute and chronic watercress supplementation attenuates exercise-induced peripheral mononuclear cell DNA damage and lipid peroxidation, Br J Nutr. 109 (2), 293-301.
  • [30] ROSE, P., FAULKNER, K., WILLIAMSON, G., MITHEN, R., 2000, 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes, Carcinogenesis, 21 (11), 1983–1988.
  • [31] YAZDANPARAST, R., BAHRAMIKIA, S., ARDESTANI, A., 2008, Nasturtium officinale reduces oxidative stress and enhances antioxidant capacity in hypercholesterolaemic rats, Chem Biol Interact., 172 (3):176-84
  • [32] HECHT, S.S., CHUNG, F.L, RICHIE, JR J.P., AKERKAR, S. A., BORUKHOVA, A, SKOWRONSKI, L., CARMELLA, S. G., 1995, Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers, Cancer Epidemiol Biomarkers Prev., 4 (8), 877-884.
  • [33] HOSSEINI S. A., MOHAMMADI, J., DELAVIZ H., SHARIATI, M., Effect of Juglansregia and Nasturtum officinalis on biochemical parameters following toxicity of kidney by CCl4 in Wistar rats, Electron J Gen Med., 15(3), 1-7.
  • [34] GINTING, H., DALIMUNTHE, A., REWENY, J., 2017, Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in Mice, Indonesian J. of Cancer Chemoprevention, 7, 9-16.
Yıl 2019, Cilt: 3 Sayı: 2, 159 - 164, 30.04.2019
https://doi.org/10.26900/jsp.3.016

Öz

Kaynakça

  • [1] GIORDANO, S., PETRELLI, A., 2008, From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage, Current Medicinal Chemistry, 15, 422. [2] BARKER, D.J., 2009, Pacific Northwest Aquatic Invasive Species Profile: Nasturtium officinale (Watercress). https://depts.washington.edu/oldenlab/wordpress/wpcontent/uploads/2013/03/Nasturtium-officinale_Barker.pdf
  • [3] DOLATKHAHI, M., DOLATKHAHI, A., & NEJAD, J.B., 2014, Ethnobotanical study of medicinal plants used in Arjan- Parishan protected area in Fars Province of Iran. Avicenna journal of phytomedicine, 4(6), 402-12. [4] ANDRADE, J. M., LUCERO MOSQUERA, H., & ARMIJOS, C., 2017. Ethnobotany of Indigenous Saraguros: Medicinal Plants Used by Community Healers "Hampiyachakkuna" in the San Lucas Parish, Southern Ecuador. BioMed research international, 9343724.
  • [5] ABBASI, A.M., KHAN, M.A., SHAH, M.H., SHAH, M.M., PERVEZ, A., AHMAD, M., 2013, Ethnobotanical appraisal and cultural values of medicinally important wild edible vegetables of Lesser Himalayas-Pakistan, J. Ethnobiol. Ethnomed., 9(1), 66.
  • [6] S. AL-QURA`N.,2006. Ethnobotany of Folk Medicinal Potentiality of Aquatic Plants in Jordan. Research Journal of Botany, 1, 75-84.
  • [7] FLAVIA, L. P., JOSE, M. F., JOAO, P. V. L., 2012. Ethnopharmacological survey: a selection strategy to identify medicinal plants for a local phytotherapy program. Brazilian Journal of Pharmaceutical Sciences, 48, (2).299-313.
  • [8] FAWZI MAHOMOODALLY, M., PRIYAMKA SREEKEESOON D., 2017, A Quantitative Ethnopharmacological Documentation of Natural Pharmacological Agents Used by Pediatric Patients in Mauritius, BioMed Research International, 1-14.
  • [9] AIRES, A., CARVALHO, R., ROSA, E.A.S., SAAVEDRA M. J., 2013, Phytochemical characterization and antioxidant properties of baby-leaf watercress produced under organic production system, CyTA, Journal of Food, 11:4, 343-351.
  • [10] ZEB, A., 2015, Phenolic profile and antioxidant potential of wild watercress (Nasturtium officinale L.). SpringerPlus, 4, 714.
  • [11] HARO, G., IKSEN, I., RUMANTİ, R.M., MARBUN, N., SARİ, R.P., GULTON, R.P.J., 2018, Evoluation of Antioxidant activity and Minerals Value From Watercress (Nasturtium officinale R.Br.), 11 (1), 232-237.
  • [12] PAHWA, R., JIALAL, I., 2018, Chronic Inflammation. StatPearls Publishing LLC, Treasure Island (FL).
  • [13] BALISTRERI, C.R., CARUSO, C., CANDORE, G., 2010, The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediat Inflamm, 802078.
  • [14] LIBRA, M., NICOLETTI, F., 2017, Diet, inflammation and cancer: a journey from prevention to treatment. In: Accardi G, Caruso C, editors. Updates in pathobiology: causality and chance in ageing, age-related diseases and longevity. Palermo, University Press, 145–162.
  • [15] ACCARDI, G., CARUSO, C., 2018, Immune-inflammatory responses in the elderly: an update. Immun Ageing, 15, 1-11.
  • [16] SANTOS J, OLIVEIRA MBPP, IBÁÑEZ E, HERRERO M. 2014, Phenolic profile evolution of different ready-to-eat baby-leaf vegetables during storage. J Chromatogr A.1327:118–31.
  • [17] AIRES, A., CARVALHO, R., ROSA, EAS, SAAVEDRA, M.J. 2013, Phytochemical characterization and antioxidant properties of baby-leaf watercress produced under organic production system. CyTA- J Food., 11, 343–51.
  • [18] MARTÍNEZ-SÁNCHEZ, A., GIL-IZQUIERDO, A., GIL, M.I., FERRERES F., 2008, A comparative study of flavonoid compounds, vitamin C, and antioxidant properties of baby leaf Brassicaceae species. J Agric Food Chem., 56, 2330–2340.
  • [19] DI NOIA, J., 2014, Defining powerhouse fruits and vegetables: a nutrient density approach. Preventing chronic disease, 11, 1-5.
  • [20] HEBATOLLAH, S., MOSTAFAZADEH, M., SADEGHI, H., MNADERİAN, MEHRZAD JAFARİ BARMAK, MOHAMMAD SHARİF TALEBİANPOOR & FOUAD MEHRABAN (2014) In vivo anti-inflammatory properties of aerial parts of Nasturtium officinale, Pharmaceutical Biology, 52(2), 169-174.
  • [21] SHAHANI, S., BEHZADFAR, F., JAHANI, D., GHASEMI, M., SHAKI, F., 2017, Antioxidant and anti-inflammatory effects of Nasturtium officinale involved in attenuation of gentamicin-induced nephrotoxicity, Toxicology Mechanisms and Methods, 27(2), 107-114.
  • [22] GILL, C.I., HALDAR, S., BOYD, L.A., BENNETT, R., WHITEFORD, J., BUTLER, M., PEARSON, J.R., BRADBURY, I., ROWLAND, I.R., 2007. Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults. Am J Clin Nutr. 85, 504–510.
  • [23] LAI K.C., HSU, S.C., KUO, C.L., IP, S.W., YANG, J.S., HSU, Y.M., HUANG H.Y., WU S.H., CHUNG, J.G., 2010, Phenethyl Isothiocyanate Inhibited Tumor Migration and Invasion via Suppressing Multiple Signal Transduction Pathways in Human Colon Cancer HT29 Cells, Journal of Agricultural and Food Chemistry, 58 (20), 11148-11155.
  • [24] PEREIRA LUCÍLIA, P., SILVA P., DUARTE, M., RODRIGUES, L., DUARTE C. M. M, ALBUQUERQUE, C., TERESA SERRA, A., 2017, Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study, Nutrients, 9(4), 368.
  • [25] ROSE, P., HUANG, Q., ONG, C.N., WHITEMAN, M., 2005, Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol. 209 (2), 105-113.
  • [26] SYED ALWI, S. S., CAVELL, B. E., TELANG, U., MORRIS, M. E., PARRY, B. M., PACKHAM, G., 2010, In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study. The British journal of nutrition, 104 (9), 1288-96.
  • [27] CAVELL, B.E., SYED ALWI S.S., DONLEVY, A., PACKHAM, G., 2011, Anti-angiogenic effects of dietary isothiocyanates: mechanisms of action and implications for human health, Biochem Pharmacol. 81 (3), 327-36.
  • [28] PAN, J H., ABERNATHY, B., KIM, Y. J., LEE J. H., KIM, J. H., SHIN, E. C., KIM J. K., 2018, Cruciferous vegetables and colorectal cancer prevention through microRNA regulation: A review, Critical Reviews in Food Science and Nutrition, 58 (12), 2026-2038.
  • [29] FOGARTY, M.C., HUGHES, C.M., BURKE, G., BROWN, J.C., DAVISON, G.W., 2013, Acute and chronic watercress supplementation attenuates exercise-induced peripheral mononuclear cell DNA damage and lipid peroxidation, Br J Nutr. 109 (2), 293-301.
  • [30] ROSE, P., FAULKNER, K., WILLIAMSON, G., MITHEN, R., 2000, 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes, Carcinogenesis, 21 (11), 1983–1988.
  • [31] YAZDANPARAST, R., BAHRAMIKIA, S., ARDESTANI, A., 2008, Nasturtium officinale reduces oxidative stress and enhances antioxidant capacity in hypercholesterolaemic rats, Chem Biol Interact., 172 (3):176-84
  • [32] HECHT, S.S., CHUNG, F.L, RICHIE, JR J.P., AKERKAR, S. A., BORUKHOVA, A, SKOWRONSKI, L., CARMELLA, S. G., 1995, Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers, Cancer Epidemiol Biomarkers Prev., 4 (8), 877-884.
  • [33] HOSSEINI S. A., MOHAMMADI, J., DELAVIZ H., SHARIATI, M., Effect of Juglansregia and Nasturtum officinalis on biochemical parameters following toxicity of kidney by CCl4 in Wistar rats, Electron J Gen Med., 15(3), 1-7.
  • [34] GINTING, H., DALIMUNTHE, A., REWENY, J., 2017, Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in Mice, Indonesian J. of Cancer Chemoprevention, 7, 9-16.
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Health Sciences
Yazarlar

Erkan Yalçınkaya Bu kişi benim 0000-0003-3458-6073

Serdar Özgüç Bu kişi benim 0000-0001-9904-9098

Yusuf Orçun Törer Bu kişi benim 0000-0003-3434-2132

Ulvi Zeybek Bu kişi benim 0000-0003-1053-8771

Yayımlanma Tarihi 30 Nisan 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 3 Sayı: 2

Kaynak Göster

APA Yalçınkaya, E., Özgüç, S., Törer, Y. O., Zeybek, U. (2019). THE IMPORTANCE OF THE MEDICINAL PLANT NASTURTIUM OFFICINALE L. IN THE ANTICANCER ACTIVITY RESEARCH. Journal of Scientific Perspectives, 3(2), 159-164. https://doi.org/10.26900/jsp.3.016