Year 2018, Volume 21, Issue 3, Pages 187 - 192 2018-12-02

Tip 2 Diabetes Mellitusu Olan Kalp Yetmezlikli Hastalarda HbA1c Seviyesi ile Beck Depresyon Skalası Arasındaki İlişki
The Relationship Between HbA1c Level and Beck Depression Scale in Patients with Heart Failure with Type 2 Diabetes Mellitus

Mahmut Yesin [1] , Metin Çağdaş [2] , Macit Kalcik [3] , İbrahim Rencüzoğulları [4] , Yavuz Karabağ [5] , Ozan Mustafa Gürsoy [6] , Yüksel Kıvrak [7] , Süleyman Karakoyun [8]

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Giriş: Birçok çalışma kalp yetmezliği ile depresyon gelişimi arasındaki ilişkiyi göstermiştir. Bazı çalışmalar tip 2 diabetes mellitus (DM) olanlarda yaşam kalitesinin bozulduğunu göstermiştir. Diyabetik kalp yetmezlikli hastalarda HbA1c düzeyleri ile depresyon arasındaki ilişkiyi değerlendirmeyi amaçladık. 

Hastalar ve Yöntem: Temmuz 2015 ve Haziran 2016 tarihleri arasında, 179 Tip 2 DM’li kalp yetmezliği olan (LV-EF < %35) hastalar çalışmaya dahil edildi. Tip 2 DM’li hastalardan HbA1c için kan örnekleri alındı. Depresyonun şiddeti Beck Depresyon Envanteri (BDE) kullanılarak değerlendirildi. Depresyonu olan hastalar aşağıdaki gibi sınıflandırıldı: minimal skor 0-13 (grup I), hafif skor 14-19 (grup II), orta skor 20-28 (grup III) ve şiddetli skor 29-63 (grup IV).

Bulgular: Çalışma popülasyonunun medyan yaşı 64 (57-75) idi (kadın: 98, erkek: 81). Hipertansiyon ve cinsiyet sıklığı açısından gruplar arasında anlamlı fark yoktu. BDE skorlama sistemine göre sınıflandırılan hastaların sayısı, I ila IV. gruplarda sırasıyla 42, 45, 46 ve 46 idi. Kalp yetmezliği olan hastalarda BDE ve HbA1c düzeyleri arasında anlamlı pozitif korelasyon vardı (r= 0.488, p< 0.001). Gruplar arasında yapılan analizlere göre HbA1c değerleri grup 4 te grup I, II ve III’e göre anlamlı olarak yüksek bulundu (6.0 ± 1.47, 6.4 ± 0.6, 7.03 ± 0.7, 7.6 ± 1.23, sırasıyla, p< 0.001).

Sonuç: Tip 2 DM’li kronik kalp yetmezlikli hastalarda BDE ve HbA1c düzeyleri arasında anlamlı ilişki saptadık. Bu nedenle, kan glukoz seviyesinin daha sıkı kontrolü, diyabetik kalp yetmezlikli hastalarda yaşam kalitesini artırabilir ve depresif belirtileri azaltabilir.
Introduction: Multiple studies have shown the relationship between heart failure (HF) and development of depression. Several studies have demonstrated worse perception of quality of life among patients with type 2 diabetes mellitus (T2DM). We aimed to assess the association between glycated hemoglobin (HbA1c) levels and depression severity in patients with diabetic HF.

Patients and Methods: Between July 2015 and June 2016, 179 patients with HF (left ventricular ejection fraction < 35%) and T2DM were included in the study. Blood samples for HbA1c were obtained from patients with T2DM. The severity of depression was assessed using the Beck Depression Inventory (BDI). Patients with depression were classified as follows: minimal with score 0-13 (group I), mild with score 14-19 (group II), moderate with score 20-28 (group III), and severe with score 29-63 (group IV).

Results: The median age of the study population was 64 (57-75) years (98 females and 81 males). There was no significant difference between the groups regarding the frequency of hypertension and gender. There was a significant positive correlation between BDI and HbA1c levels in patients with HF (r= 0.488, p< 0.001). According to the analysis performed between the groups, HbA1c values were found to be significantly higher in group IV than in groups I, II, and III (6.0 ± 1.47, 6.4 ± 0.6, 7.03 ± 0.7, and 7.6 ± 1.23, respectively; p< 0.001), which indicate the association between severity of depression and HbA1c level.

Conclusion: We detected a significant association between BDI and HbA1c level in patients with chronic HF with T2DM. Therefore, more strict control of blood glucose level may improve quality of life and decrease depressive symptoms in patients with diabetic HF.
  • 1. Chin MH, Goldman L. Gender differences in 1-year survival and quality of life among patients admitted with congestive heart failure. Med Care 1998;36:1033-46.
  • 2. Yeh GY, Wood MJ, Lorell BH, Stevenson LW, Eisenberg DM, Wayne PM, et al. Effects of tai chi mind-body movement therapy on functional status and exercise capacity in patients with chronic heart failure: a randomized controlled trial. Am J Med 2004;117:541-8.
  • 3. Hawthorne MH, Hixon ME. Functional status, mood disturbance and quality of life in patients with heart failure. Prog Cardiovasc Nurs 1994;9:22-32.
  • 4. Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med 2000;160:3278-85.
  • 5. Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure a metaanalytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol 2006;48:1527-37.
  • 6. Khamseh ME, Baradaran HR, Rajabali H. Depression and diabetes in Iranian patients: a comparative study. Int J Psychiatry Med 2007;37:81-6.
  • 7. Larijani B, Khoram Shahi Baiat M, Khalili Gorgani M, Bandarian F, Akhondzadeh S, Sadjadi SA. Association between depression and diabetes. German J Psychiatry 2004;7:62-5.
  • 8. Junger J, Schellberg D, Muller-Tasch T, Raupp G, Zugck C, Haunstetter A, et al. Depression increasingly predicts mortality in the course of congestive heart failure. Eur J Heart Fail 2005;7:261-7.
  • 9. Dogdu O, Yarlioglues M, Kaya MG, Ardic I, Akpek M, Senarslan O, et al. Relationship between psychosocial status, diabetes mellitus,and left ventricular systolic function in patients with stable multivessel coronary artery disease. Cardiol J 2012;19:249-55.
  • 10. American Diabetes Association: Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2010;33:S629.
  • 11. Lustman PJ, Clouse RE, Griffith LS, Carney RM, Freedland KE. Screening for depression in diabetes using the Beck Depression Inventory. Psychosom Med 1997;59:24-31.
  • 12. Tousoulis D, Antonopoulos AS, Antoniades C, Saldari C, Stefanadi E, Siasos G, et al. Role of depression in heart failuredchoosing the right antidepressive treatment. Int J Cardiol 2010;140:12e8.
  • 13. Kroenke K, Spitzer RL, Williams JBW. The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care 2003;41:1284-92.
  • 14. Freedland K, Rich M, Skala J, Carney R, Davila-Roman V, Jaffe A. Prevalence of depression in hospitalised patients with congestive heart failure. Psychosom Med 2003;65:119e28.
  • 15. Carels RA. The association between disease severity, functional status, depression and daily quality of life in congestive heart failure patients. Qual Life Res 2004;13:63-72.
  • 16. Faller H, Störk S, Schuler M, Schowalter M, Steinbüchel T, Ertl G, et al. Depression and disease severity as predictors of health-related quality of life in patients with chronic heart failure--a structural equation modeling approach. J Card Fail 2009;15:286-292.e2.
  • 17. Gottlieb SS, Khatta M, Friedmann E, Einbinder L, Katzen S, Baker B, et al. The influence of age, gender, and race on the prevalence of depression in heart failure patients. J Am Coll Cardiol 2004;43:1542-9.
  • 18. Lustman PJ, Anderson RJ, Freedland KE, De Groot M, Carney RM, Clouse RE. Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care 2000;23:934-42.
  • 19. O’Connor PJ, Crain AL, Rush WA, Hanson AM, Fischer LR, Kluznik JC. Does diabetes double the risk of depression? Ann Fam Med 2009;7:328-35.
  • 20. Papelbaum M, Moreira RO, Coutinho W, Kupfer R, Zagury L, Freitas S, et al. Depression, glycemic control and type 2 diabetes. Diabetol Metab Syndr 2011;3:26.
  • 21. Siddiqui S. Depression in type 2 diabetes mellitus--a brief review. Diabetes Metab Syndr 2014;8:62-5.
  • 22. Ferreira MC, Piaia C, Cadore AC, Antoniolli MA, Gamborgi GP, Oliveira PP. Clinical variables associated with depression in patients with type 2 diabetes. Rev Assoc Med Bras (1992) 2015;61:336-40.
Primary Language en
Subjects Medicine
Journal Section Original Investigations
Authors

Author: Mahmut Yesin (Primary Author)
Institution: Kars State Hospital, Clinic of Cardiology, Kars, Turkey

Author: Metin Çağdaş
Institution: University of Kafkas, Faculty of Medicine, Department of Cardiology, Kars, Turkey

Author: Macit Kalcik
Institution: University of Hitit, Faculty of Medicine, Department of Cardiology, Çorum, Turkey

Author: İbrahim Rencüzoğulları
Institution: University of Kafkas, Faculty of Medicine, Department of Cardiology, Kars, Turkey

Author: Yavuz Karabağ
Institution: University of Kafkas, Faculty of Medicine, Department of Cardiology, Kars, Turkey

Author: Ozan Mustafa Gürsoy
Institution: Gaziemir State Hospital, Clinic of Cardiology, İzmir, Turkey

Author: Yüksel Kıvrak
Institution: University of Kafkas, Faculty of Medicine, Department of Psychiatry, Kars, Turkey

Author: Süleyman Karakoyun
Institution: University of Kafkas, Faculty of Medicine, Department of Cardiology, Kars, Turkey

Bibtex @research article { khj494751, journal = {Koşuyolu Heart Journal}, issn = {2149-2972}, eissn = {2149-2980}, address = {Kartal Koşuyolu Yüksek İhtisas EAH}, year = {2018}, volume = {21}, pages = {187 - 192}, doi = {}, title = {The Relationship Between HbA1c Level and Beck Depression Scale in Patients with Heart Failure with Type 2 Diabetes Mellitus}, key = {cite}, author = {Yesin, Mahmut and Çağdaş, Metin and Kalcik, Macit and Rencüzoğulları, İbrahim and Karabağ, Yavuz and Gürsoy, Ozan Mustafa and Kıvrak, Yüksel and Karakoyun, Süleyman} }
APA Yesin, M , Çağdaş, M , Kalcik, M , Rencüzoğulları, İ , Karabağ, Y , Gürsoy, O , Kıvrak, Y , Karakoyun, S . (2018). The Relationship Between HbA1c Level and Beck Depression Scale in Patients with Heart Failure with Type 2 Diabetes Mellitus. Koşuyolu Heart Journal, 21 (3), 187-192. Retrieved from http://dergipark.org.tr/khj/issue/40963/494751
MLA Yesin, M , Çağdaş, M , Kalcik, M , Rencüzoğulları, İ , Karabağ, Y , Gürsoy, O , Kıvrak, Y , Karakoyun, S . "The Relationship Between HbA1c Level and Beck Depression Scale in Patients with Heart Failure with Type 2 Diabetes Mellitus". Koşuyolu Heart Journal 21 (2018): 187-192 <http://dergipark.org.tr/khj/issue/40963/494751>
Chicago Yesin, M , Çağdaş, M , Kalcik, M , Rencüzoğulları, İ , Karabağ, Y , Gürsoy, O , Kıvrak, Y , Karakoyun, S . "The Relationship Between HbA1c Level and Beck Depression Scale in Patients with Heart Failure with Type 2 Diabetes Mellitus". Koşuyolu Heart Journal 21 (2018): 187-192
RIS TY - JOUR T1 - The Relationship Between HbA1c Level and Beck Depression Scale in Patients with Heart Failure with Type 2 Diabetes Mellitus AU - Mahmut Yesin , Metin Çağdaş , Macit Kalcik , İbrahim Rencüzoğulları , Yavuz Karabağ , Ozan Mustafa Gürsoy , Yüksel Kıvrak , Süleyman Karakoyun Y1 - 2018 PY - 2018 N1 - DO - T2 - Koşuyolu Heart Journal JF - Journal JO - JOR SP - 187 EP - 192 VL - 21 IS - 3 SN - 2149-2972-2149-2980 M3 - UR - Y2 - 2019 ER -
EndNote %0 Koşuyolu Heart Journal The Relationship Between HbA1c Level and Beck Depression Scale in Patients with Heart Failure with Type 2 Diabetes Mellitus %A Mahmut Yesin , Metin Çağdaş , Macit Kalcik , İbrahim Rencüzoğulları , Yavuz Karabağ , Ozan Mustafa Gürsoy , Yüksel Kıvrak , Süleyman Karakoyun %T The Relationship Between HbA1c Level and Beck Depression Scale in Patients with Heart Failure with Type 2 Diabetes Mellitus %D 2018 %J Koşuyolu Heart Journal %P 2149-2972-2149-2980 %V 21 %N 3 %R %U
ISNAD Yesin, Mahmut , Çağdaş, Metin , Kalcik, Macit , Rencüzoğulları, İbrahim , Karabağ, Yavuz , Gürsoy, Ozan Mustafa , Kıvrak, Yüksel , Karakoyun, Süleyman . "The Relationship Between HbA1c Level and Beck Depression Scale in Patients with Heart Failure with Type 2 Diabetes Mellitus". Koşuyolu Heart Journal 21 / 3 (December 2018): 187-192.