Öz
Amaç: Bu çalışma ile inflamasyon belirteçleri ile antropometrik ölçüm değerleri ve kan lipit değerleri arasındaki ilişkinin tespit edilmesi amaçlanmıştır.
Gereç ve Yöntem: Bu çalışma 2019 yılında 274 yetişkin sağlıklı kişi üstünde yapılmış bir çalışmadır. Kişilerin kan lipit değerleri, tam kan sayımı inflamasyon belirteçleri nötrofil lenfosit oranı (NLO), platelet lenfosit oranı (PLO) ve lenfosit monosit oranı (LMO) ile antropometrik ölçümleri arasındaki ilişki incelenmiştir.
Bulgular: Çalışmaya katılan 274 kişinin yaş ortalaması 34’dür. BKİ’ne göre NLO, PLO ve LMO oranları arasında anlamlı fark bulunamamıştır. PLO ile iskelet kası, bazal metabolik hız, vücut sıvı miktarı ve yağsız kütle arasında anlamlı çok zayıf negatif korelasyon, HDL ile BMİ, vücut yağ miktarı, iç yağlanma miktarı arasında zayıf negatif yönde korelasyon bulunmuştur. İskelet kası ve vücut yağ miktarındaki artış total kolesterol seviyesinde azalışa neden olurken, iç yağlanma miktarındaki artış total kolesterol seviyesinde artışa neden olmaktadır. NLO ile LDL arasında pozitif yönde zayıf, NLO ile total kolesterol arasında pozitif yönde çok zayıf, LMO ile LDL arasında pozitif yönde çok zayıf korelasyon bulunmuştur.
Sonuç: Antropometrik değerler ile inflamasyon belirteçleri arasında çok zayıf, kan lipit ile zayıf-orta düzey, inflamasyon belirteçleri ile kolesterol düzeyi arasında zayıf ilişki olduğu görülmüştür.
Anahtar Kelimeler
inflamasyon mediyatörleri vücut kitle indeksi kolesterol nötrofiller
Kaynakça
- Referans 1- Bastard JP, Maachi M, Van Nhieu JT, Jardel C, Bruckert E, Grimaldi A et al. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metab. 2002;87:2084-89. Referans 2- Pitsavos C, Tampourlou M, Panagiotakos DB, Skoumas Y, Chrysohoou C, Nomikos T et al. Association between low-grade systemic inflammation and type 2 diabetes mellitus among men and women from the ATTICA study. RDS. 2007;4:98. Referans 3- Nakanishi N, Sato M, Shirai K, Suzuki K, Tatara K. White blood cell count as a risk factor for hypertension; a study of Japanese male office workers. J Hypertens. 2002;20:851-57. Referans 4- Bell DS, O’Keefe JH, White cell count, mortality, and metabolic syndrome in the Baltimore longitudinal study of aging. J Am Coll Cardiol 2007;50:1810-1811. Referans 5- Marsland AL, McCaffery JM, Muldoon MF, Manuck SB. Systemic inflammation and the metabolic syndrome among middle-aged community volunteers. Metabolism. 2010;59:1801–08. Referans 6- Brooks GC, Blaha MJ, Blumenthal RS. Relation of C-Reactive Protein to Abdominal Adiposity. Am J Cardiol. 2010;106:56–61. Referans 7- Yasue H, Hirai N, Mizuno Y, Harada E, Itoh T, Yoshimura M et al. Low-Grade Inflammation, Thrombogenicity, and Atherogenic Lipid Profile in Cigarette Smokers. Circ. J. 2006;70:8–13. Referans 8- Pirkola J, Vääräsmäki M, Ala-Korpela M, Bloigu A, Canoy D, Hartikainen AL et al. Low-Grade, Systemic Inflammation in Adolescents: Association With Early-Life Factors, Gender, and Lifestyle. Am J Epidemiol. 2009;171:72–82. Referans 9- Bovill EG, Bild DE, Heiss G, Kuller LH, Lee MH, Rock R et al. White Blood Cell Counts in Persons Aged 65 Years or More from the Cardiovascular Health Study: Correlations with Baseline Clinical and Demographic Characteristics. Am J Epidemiol. 1996;143:1107-15. Referans 10- Freedman DS, Joesoef MR, Barboriak JJ, Stallone DD, Byers T. Correlates of leukocyte counts in men. Ann Epidemiol.1996;6:74–82. Referans 11- Facchını F, Hollenbeck Cb, Chen Yn, Chen Y-Dı, Reaven Gm. Demonstration of a relationship between white blood cell count, insulin resistance, and several risk factors for coronary heart disease in women. J Intern Med. 1992;232:267–72. Referans 12- Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J. 2007;154:995–02. Referans 13- Faam B, Zarkesh M, Daneshpour MS, Azizi F, Hedayati M. The association between inflammatory markers and obesity-related factors in Tehranian adults: Tehran lipid and glucose study. Iran J Basic Med Sci. 2014;17:577. Referans 14- Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil–lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol. 2013;88:218-30. Referans 15- Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K et al. A central role for JNK in obesity and insulin resistance. Nature. 2002;420:333. Referans 16- Atmaca HU, Akbaş F, Ökten İN, Nuhoğlu E, İnal BB. Can Neutrophil-to-Lymphocyte Ratio Serve as an Inflammatory Marker in Obesity? İstanbul Med J 2014;15:216-20 Referans 17- Koca TT. Does obesity cause chronic inflammation? The association between complete blood parameters with body mass index and fasting glucose. Pak J Med Sci. 2017;33:65-69 Referans 18- Karakaya S, Altay M, Kaplan Efe F, Karadağ İ, Ünsal O, Bulur O et al. The neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity. Turk J Med Sci. 2019;49:245-48. Referans 19- Çakıroğlu Y, Vural F, Vural B. The inflammatory markers in polycystic ovary syndrome: association with obesity and IVF outcomes. J Endocrinol Invest 2016;39:899-07. Referans 20- Yılmaz MA, Duran C, Başaran M. The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome. J Endocrinol Invest. 2016;39:45-53. Referans 21- Aydın M, Yılmaz A, Donma MM, Tulubas F, Demirkol M, Erdogan M et al. Neutrophil/lymphocyte ratio in obese adolescents. North Clin Istanb. 2015;2:87–91 Referans 22- Furuncuoğlu Y, Tulgar S, Doğan AN, Çakar S, Tulgar YK, Cakiroglu B. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: a retrospective study. Eur Rev Med Pharmacol Sci. 2016;20:1300-06. Referans 23- Nalbant A, Konuk S. Association of obesity with vitamin D, C-reactive protein, blood group and hemogram parameters Ortadoğu Tıp Dergisi. 2018;10:20-25. Referans 24- Suárez-Cuenca JA, Ruíz-Hernández AS, Mendoza-Castañeda AA, Domínguez-Pérez GA, Hernández-Patricio A, Vera-Gómez E,et al. Neutrophil‐to‐lymphocyte ratio and its relation with pro‐inflammatory mediators, visceral adiposity and carotid intima‐media thickness in population with obesity. Eur J Clin Invest. 2019;49:5. Referans 25- Faam B, Zarkesh M, Daneshpour MS, Azizi F, Hedayati M. The association between inflammatory markers and obesity-related factors in Tehranian adults: Tehran lipid and glucose study. Iran J Basic Med Sci. 2014;17:577. Referans 26- Yu JY, Choi WJ, Lee HS, Lee JW. Relationship between inflammatory markers and visceral obesity in obese and overweight Korean adults: An observational study. Medicine. 2019;98:147 Referans 27- Syauqy A, Hsu CY, Rau HH, Chao JC. Association of dietary patterns, anthropometric measurements, and metabolic parameters with C-reactive protein and neutrophil-to-lymphocyte ratio in middle-aged and older adults with metabolic syndrome in Taiwan: a cross-sectional study. Nutr J. 2018;17:106. Referans 28- Al-Sufyani AA, Mahassni SH. Obesity and immune cells in Saudi females. Innate Immun. 2011;17:439-50. Referans 29- Bahadır A, Baltacı D, Türker Y, Türker Y, Iliev D, Öztürk S et al. Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome? Anatol J Cardiol. 2015;15:816.
Öz
Purpose: The aim of this stuıdy was to determine the relation between inflammation markers, anthropometric measurements, and blood lipid values.
Materials and Methods: The present study was conducted with 274 adult healthy subjects in 2019. The relationship between anthropometric measurements and blood lipid values of individuals, full blood count inflammation markers, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and lymphocyte monocyte ratio (LMR) were examined..
Results: The average age of the 274 subjects, who participated in the study, was 34 years. No significant differences were detected between the NLR, PLR and LMR ratios according to the BMI scores. A very weak and negative correlation was detected between PLR and skeletal muscle, basal metabolic rate, body fluid amount and lean mass; and a weak and negative correlation was detected between HDL and BMI, body fat amount, and internal fat amount. A weak and positive correlation was detected between NLR and LDL.
Conclusion: There was a very weak correlation between anthropometric values and inflammation markers, a weak-moderate correlation between blood lipid levels, and a weak correlation between inflammation markers and cholesterol levels.
Kaynakça
- Referans 1- Bastard JP, Maachi M, Van Nhieu JT, Jardel C, Bruckert E, Grimaldi A et al. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metab. 2002;87:2084-89. Referans 2- Pitsavos C, Tampourlou M, Panagiotakos DB, Skoumas Y, Chrysohoou C, Nomikos T et al. Association between low-grade systemic inflammation and type 2 diabetes mellitus among men and women from the ATTICA study. RDS. 2007;4:98. Referans 3- Nakanishi N, Sato M, Shirai K, Suzuki K, Tatara K. White blood cell count as a risk factor for hypertension; a study of Japanese male office workers. J Hypertens. 2002;20:851-57. Referans 4- Bell DS, O’Keefe JH, White cell count, mortality, and metabolic syndrome in the Baltimore longitudinal study of aging. J Am Coll Cardiol 2007;50:1810-1811. Referans 5- Marsland AL, McCaffery JM, Muldoon MF, Manuck SB. Systemic inflammation and the metabolic syndrome among middle-aged community volunteers. Metabolism. 2010;59:1801–08. Referans 6- Brooks GC, Blaha MJ, Blumenthal RS. Relation of C-Reactive Protein to Abdominal Adiposity. Am J Cardiol. 2010;106:56–61. Referans 7- Yasue H, Hirai N, Mizuno Y, Harada E, Itoh T, Yoshimura M et al. Low-Grade Inflammation, Thrombogenicity, and Atherogenic Lipid Profile in Cigarette Smokers. Circ. J. 2006;70:8–13. Referans 8- Pirkola J, Vääräsmäki M, Ala-Korpela M, Bloigu A, Canoy D, Hartikainen AL et al. Low-Grade, Systemic Inflammation in Adolescents: Association With Early-Life Factors, Gender, and Lifestyle. Am J Epidemiol. 2009;171:72–82. Referans 9- Bovill EG, Bild DE, Heiss G, Kuller LH, Lee MH, Rock R et al. White Blood Cell Counts in Persons Aged 65 Years or More from the Cardiovascular Health Study: Correlations with Baseline Clinical and Demographic Characteristics. Am J Epidemiol. 1996;143:1107-15. Referans 10- Freedman DS, Joesoef MR, Barboriak JJ, Stallone DD, Byers T. Correlates of leukocyte counts in men. Ann Epidemiol.1996;6:74–82. Referans 11- Facchını F, Hollenbeck Cb, Chen Yn, Chen Y-Dı, Reaven Gm. Demonstration of a relationship between white blood cell count, insulin resistance, and several risk factors for coronary heart disease in women. J Intern Med. 1992;232:267–72. Referans 12- Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J. 2007;154:995–02. Referans 13- Faam B, Zarkesh M, Daneshpour MS, Azizi F, Hedayati M. The association between inflammatory markers and obesity-related factors in Tehranian adults: Tehran lipid and glucose study. Iran J Basic Med Sci. 2014;17:577. Referans 14- Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil–lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol. 2013;88:218-30. Referans 15- Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K et al. A central role for JNK in obesity and insulin resistance. Nature. 2002;420:333. Referans 16- Atmaca HU, Akbaş F, Ökten İN, Nuhoğlu E, İnal BB. Can Neutrophil-to-Lymphocyte Ratio Serve as an Inflammatory Marker in Obesity? İstanbul Med J 2014;15:216-20 Referans 17- Koca TT. Does obesity cause chronic inflammation? The association between complete blood parameters with body mass index and fasting glucose. Pak J Med Sci. 2017;33:65-69 Referans 18- Karakaya S, Altay M, Kaplan Efe F, Karadağ İ, Ünsal O, Bulur O et al. The neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity. Turk J Med Sci. 2019;49:245-48. Referans 19- Çakıroğlu Y, Vural F, Vural B. The inflammatory markers in polycystic ovary syndrome: association with obesity and IVF outcomes. J Endocrinol Invest 2016;39:899-07. Referans 20- Yılmaz MA, Duran C, Başaran M. The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome. J Endocrinol Invest. 2016;39:45-53. Referans 21- Aydın M, Yılmaz A, Donma MM, Tulubas F, Demirkol M, Erdogan M et al. Neutrophil/lymphocyte ratio in obese adolescents. North Clin Istanb. 2015;2:87–91 Referans 22- Furuncuoğlu Y, Tulgar S, Doğan AN, Çakar S, Tulgar YK, Cakiroglu B. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: a retrospective study. Eur Rev Med Pharmacol Sci. 2016;20:1300-06. Referans 23- Nalbant A, Konuk S. Association of obesity with vitamin D, C-reactive protein, blood group and hemogram parameters Ortadoğu Tıp Dergisi. 2018;10:20-25. Referans 24- Suárez-Cuenca JA, Ruíz-Hernández AS, Mendoza-Castañeda AA, Domínguez-Pérez GA, Hernández-Patricio A, Vera-Gómez E,et al. Neutrophil‐to‐lymphocyte ratio and its relation with pro‐inflammatory mediators, visceral adiposity and carotid intima‐media thickness in population with obesity. Eur J Clin Invest. 2019;49:5. Referans 25- Faam B, Zarkesh M, Daneshpour MS, Azizi F, Hedayati M. The association between inflammatory markers and obesity-related factors in Tehranian adults: Tehran lipid and glucose study. Iran J Basic Med Sci. 2014;17:577. Referans 26- Yu JY, Choi WJ, Lee HS, Lee JW. Relationship between inflammatory markers and visceral obesity in obese and overweight Korean adults: An observational study. Medicine. 2019;98:147 Referans 27- Syauqy A, Hsu CY, Rau HH, Chao JC. Association of dietary patterns, anthropometric measurements, and metabolic parameters with C-reactive protein and neutrophil-to-lymphocyte ratio in middle-aged and older adults with metabolic syndrome in Taiwan: a cross-sectional study. Nutr J. 2018;17:106. Referans 28- Al-Sufyani AA, Mahassni SH. Obesity and immune cells in Saudi females. Innate Immun. 2011;17:439-50. Referans 29- Bahadır A, Baltacı D, Türker Y, Türker Y, Iliev D, Öztürk S et al. Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome? Anatol J Cardiol. 2015;15:816.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Araştırma |
| Yazarlar | |
| Yayımlanma Tarihi | 27 Aralık 2020 |
| Kabul Tarihi | 19 Ağustos 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 45 Sayı: 4 |
Cited By
