Araştırma Makalesi
BibTex RIS Kaynak Göster

Yıl 2019, Cilt: 3 Sayı: 2, 146 - 150, 31.12.2019

Hakan Soyut

https://doi.org/10.32571/ijct.651334

Öz

Kaynakça

  • 1. Bandettini di Poggio, M.; Anfosso, S.; Audenino, D.; Primavera, A. J. Clin. Neurosci. 2011, 18, 313-318.
  • 2. Giamarellos-Bourboulis, E.J.; Antonopoulou, A.; Raftogiannis, M.. Koutoukas P, Tsaganos, T., Tziortzioti, V., Panagou, C., Adamis, T., Giamarellou, H. BMC Infect. Dis. 2006, 21, 31.
  • 3. Cheathama, S. C.; Shea, K. M.; Healy, D. P.; Humphrey, M. L.; Fleming, M. R.; Wack, M. F.; Smith, D. W.; Sowinski, K. M.; Kays, M. B. Int. J. Antimicrob. AG. 2011, 37 (1), 46-50.
  • 5. Singh, A. K.; Quraishi, M. A. Corros. Sci. 2010, 52, 152-160.
  • 6. Khersonsky, O.; Tawfik, D. S. Biochemistry 2005, 44, 6371-6382.
  • 7. Türkeş, C.; Söyüt, H.; Beydemir, Ş. Pharmacol. Rep. 2014, 66, 74-78.
  • 8. Türkeş, C.; Söyüt, H.; Beydemir, Ş. J. Enzyme Inhib. Med. Ch. 2015, 30, 622–628.
  • 9. Türkeş, C.; Söyüt, H.; Beydemir, Ş. Environ. Toxicol. Phar. 2016, 42, 252-257.
  • 10. Gaidukov, L.; Tawfik, D. S. Biochemistry 2005, 44, 11843-11854.
  • 11. Renault, F.; Chabriere, E.; Andrieu, J.P.; Dublet, B.; Massona, P.; Rochua, D. J. Chromatogyr. B, 2006, 836, 15-21.
  • 12. Aviram, M.; Rosenblat, M. Free Radical Bio. Med. 2004, 37, 1304–1316.
  • 13. Rozenberg, O.; Shih, S. D.; Aviram, M. Atherosclerosis 2005, 181, 9–18.
  • 14. Ekinci, D.; Beydemir, S. J. Enzyme Inhib. Med. Ch. 2009, 24, 1034-1039.
  • 15. Ekinci, D.; Beydemir, S. Eur. J. Pharmacol. 2009, 617, 84-89.

Inhibition effects of commonly used some antibacterial and antiviral drugs on purified human serum paraoxonase-1 (hPON1)

Yıl 2019, Cilt: 3 Sayı: 2, 146 - 150, 31.12.2019

Hakan Soyut

https://doi.org/10.32571/ijct.651334

Öz

hPON1 is an enzyme from the group of A-esterases which
is capable of hydrolyzing the active metabolite paraoxon of parathion, an
organic phosphorus insecticide. It is an important liver enzyme that plays a
protective role against the hydrolysis of HDL-induced organophosphate agents
and nerve gases, oxidation of LDL, formation of lipid peroxides and bacterial
endotoxins. The fact that oxidation of LDL constitutes the initial stage of the
atherosclerosis process reveals the importance of the antioxidant properties of
the enzyme. In this study, human serum PON1 was purified using three simple
biochemical purification techniques. Furthermore, the in vitro effects of some
antibacterial and antiviral drugs on human serum PON1 enzyme activity were
examined. IC50 values were determined.

Anahtar Kelimeler

Paraoxonase enzyme inhibition antibacterial drug antiviral drug

Kaynakça

  • 1. Bandettini di Poggio, M.; Anfosso, S.; Audenino, D.; Primavera, A. J. Clin. Neurosci. 2011, 18, 313-318.
  • 2. Giamarellos-Bourboulis, E.J.; Antonopoulou, A.; Raftogiannis, M.. Koutoukas P, Tsaganos, T., Tziortzioti, V., Panagou, C., Adamis, T., Giamarellou, H. BMC Infect. Dis. 2006, 21, 31.
  • 3. Cheathama, S. C.; Shea, K. M.; Healy, D. P.; Humphrey, M. L.; Fleming, M. R.; Wack, M. F.; Smith, D. W.; Sowinski, K. M.; Kays, M. B. Int. J. Antimicrob. AG. 2011, 37 (1), 46-50.
  • 5. Singh, A. K.; Quraishi, M. A. Corros. Sci. 2010, 52, 152-160.
  • 6. Khersonsky, O.; Tawfik, D. S. Biochemistry 2005, 44, 6371-6382.
  • 7. Türkeş, C.; Söyüt, H.; Beydemir, Ş. Pharmacol. Rep. 2014, 66, 74-78.
  • 8. Türkeş, C.; Söyüt, H.; Beydemir, Ş. J. Enzyme Inhib. Med. Ch. 2015, 30, 622–628.
  • 9. Türkeş, C.; Söyüt, H.; Beydemir, Ş. Environ. Toxicol. Phar. 2016, 42, 252-257.
  • 10. Gaidukov, L.; Tawfik, D. S. Biochemistry 2005, 44, 11843-11854.
  • 11. Renault, F.; Chabriere, E.; Andrieu, J.P.; Dublet, B.; Massona, P.; Rochua, D. J. Chromatogyr. B, 2006, 836, 15-21.
  • 12. Aviram, M.; Rosenblat, M. Free Radical Bio. Med. 2004, 37, 1304–1316.
  • 13. Rozenberg, O.; Shih, S. D.; Aviram, M. Atherosclerosis 2005, 181, 9–18.
  • 14. Ekinci, D.; Beydemir, S. J. Enzyme Inhib. Med. Ch. 2009, 24, 1034-1039.
  • 15. Ekinci, D.; Beydemir, S. Eur. J. Pharmacol. 2009, 617, 84-89.
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Kimya Mühendisliği
Bölüm Makale
Yazarlar

Hakan Soyut 0000-0002-0361-7458

Yayımlanma Tarihi 31 Aralık 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 3 Sayı: 2

Kaynak Göster

APA Soyut, H. (2019). Inhibition effects of commonly used some antibacterial and antiviral drugs on purified human serum paraoxonase-1 (hPON1). International Journal of Chemistry and Technology, 3(2), 146-150. https://doi.org/10.32571/ijct.651334
AMA Soyut H. Inhibition effects of commonly used some antibacterial and antiviral drugs on purified human serum paraoxonase-1 (hPON1). Int. J. Chem. Technol. Aralık 2019;3(2):146-150. doi:10.32571/ijct.651334
Chicago Soyut, Hakan. “Inhibition Effects of Commonly Used Some Antibacterial and Antiviral Drugs on Purified Human Serum Paraoxonase-1 (hPON1)”. International Journal of Chemistry and Technology 3, sy. 2 (Aralık 2019): 146-50. https://doi.org/10.32571/ijct.651334.
EndNote Soyut H (01 Aralık 2019) Inhibition effects of commonly used some antibacterial and antiviral drugs on purified human serum paraoxonase-1 (hPON1). International Journal of Chemistry and Technology 3 2 146–150.
IEEE H. Soyut, “Inhibition effects of commonly used some antibacterial and antiviral drugs on purified human serum paraoxonase-1 (hPON1)”, Int. J. Chem. Technol., c. 3, sy. 2, ss. 146–150, 2019, doi: 10.32571/ijct.651334.
ISNAD Soyut, Hakan. “Inhibition Effects of Commonly Used Some Antibacterial and Antiviral Drugs on Purified Human Serum Paraoxonase-1 (hPON1)”. International Journal of Chemistry and Technology 3/2 (Aralık 2019), 146-150. https://doi.org/10.32571/ijct.651334.
JAMA Soyut H. Inhibition effects of commonly used some antibacterial and antiviral drugs on purified human serum paraoxonase-1 (hPON1). Int. J. Chem. Technol. 2019;3:146–150.
MLA Soyut, Hakan. “Inhibition Effects of Commonly Used Some Antibacterial and Antiviral Drugs on Purified Human Serum Paraoxonase-1 (hPON1)”. International Journal of Chemistry and Technology, c. 3, sy. 2, 2019, ss. 146-50, doi:10.32571/ijct.651334.
Vancouver Soyut H. Inhibition effects of commonly used some antibacterial and antiviral drugs on purified human serum paraoxonase-1 (hPON1). Int. J. Chem. Technol. 2019;3(2):146-50.
 Kapak Resmi İndir

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