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Changes in Hematological Parameters Associated with Vaginal Hyperplasia and Vaginal Tumors in Bitches

Yıl 2021, Cilt: 14 Sayı: 1, 62 - 66, 30.06.2021

Zeynep Günay Uçmak Özge Erdoğan Bamaç

https://doi.org/10.47027/duvetfd.892302

Öz

The aim of the study is to evaluate the changes in clinical, hematological and histopathological parameters of the bitches with vaginal hyperplasia (VH), vaginal tumors (VT) and healthy reproductive tract (H), respectively. The study groups formed as; group VH (n=9), group VT (n=10) and group H (n=13). All bitches were examined clinically (vaginal cytology, vaginoscopy), hematologically and histopatologically. The bitches in group H were in anestrus and the bitches in group VH and group VT were in oestrus. Reduced levels of RBC, HGB, HCT and increase in WBC were detected in group VT. The averages of HGB level in group VH was tended to be lower than group H (P=0.05) while the averages of HCT level in group VH was significantly lower than to group H. The averages of RBC, HGB, HCT and WBC were not significantly associated with the degree of vaginal fold prolapse (VFP) (P>0.05) while the averages of PLT and PCT in bitches with type 2 VH were tended to be higher than type 3 VH (P=0.07). The histopathological examination of the vaginal masses in group VH revealed thickening of squamous epithelium and significantly loose and edematous connective tissue in the lamina propria. Histological diagnosis of the tumors in group VT were fibroma (n=4), leiomyoma (n=3), peripheral nerve sheath tumor (n=1), transmissible venereal tumor (TVT) (n=1) and leiomyosarcoma (n=1). In conclusion, hematological changes in bitches with vaginal mass were evaluated and mild anemia and leukocytosis were determined in bitches with VH and VT. To our knowledge, this is the first study that demonstrates the detection of mild anemia in bitches with VH and the differences in PLT and PCT related to the degree of VFP.

Anahtar Kelimeler

Bitches hematology vaginal mass

Kaynakça

  • 1-Manothaiudom K, Johnston SD. (1991). Clinical Approach to Vaginal/ Vestibular Masses in the Bitch. Vet Clin North Am Small Anim Pract. 21(3): 509-521.
  • 2-Sontaş BH, Ekici H, Romagnoli S. (2010). Canine Vaginal Fold Prolapse: A Comprehensive Literature Review. EJCAP. 20(2): 127-135.
  • 3-Nak D, Nak Y, Yılmazbaş G. (2008). First Report of Vaginal Prolapse in an Ovariohysterectomised Bitch - A Case Report. Bull Vet Inst Pulawy. 52: 397-398.
  • 4-Alan M, Çetin Y, Sendag S, Eski F. (2007). True Vaginal Prolapse in a Bitch. Anim Reprod Sci. 100: 411–414.
  • 5-Canoğlu E. (2013). Köpeklerde Vaginal Hiperplazi: Tanı ve Tedavi Seçenekleri. Erciyes Univ Vet Fak Derg. 10(3): 177-183.
  • 6-Babu A, Becha BB, Jayakumar C, Simon S, Raj IV, Kurien MO. (2020). Occurrence of Vaginal Hyperplasia Among Intact Dogs. J. Vet. Anim. Sci. 51(2): 142-145.
  • 7-Gouletsou PG, Galatos AD, Apostolidis K, Sideri AI. (2009). Vaginal Fold Prolapse During the Last Third of Pregnancy, Followed by Normal Parturition, in a Bitch. Anim Reprod Sci. 112: 371–376.
  • 8-Kurt S, Salar S, Baştan A. (2019). Effect of Vaginal Fold Prolapse Occurrence in a Pregnant Bitch on Parturition Process. Vet Hekim Der Derg. 90(1): 50-54.
  • 9-Şafak T, Yılmaz Ö, Ercan K, Yüksel BF, Öcal H. (2021). A Case of Vaginal Hyperplasia Occurred the Last Trimester of Pregnancy in a Kangal Bitch. Ankara Univ Vet Fak Derg. DOI: 10.33988/auvfd.764656
  • 10- Schutte AP. (1967). Vaginal Prolapse in the Bitch. J South Afr Vet Med Assoc. 38: 197-203.
  • 11- Soderberg SF. (1986). Vaginal Disorders. Vet Clin North Am Small Anim Pract. 16: 543-559.
  • 12- Post K, Haaften BV, Okkens AC. (1991). Vaginal Hyperplasia in the Bitch: Literature Review and Commentary. Can Vet J. 32(1): 35-37.
  • 13-Troger CP. (1970). Vaginal Prolapse in the Bitch. Mod Vet Prac. 51: 38-41.
  • 14-McEntee MC. (2002). Reproductive Oncology. Clin Tech Small Anim Pract. 17(3): 133–149.
  • 15-Kydd DM, Burnie AG. (1986). Vaginal Neoplasia in the Bitch: a Review of Forty Clinical Cases. J. Small Anim Pract. 27: 255-263.
  • 16-Thacher C, Bradley RL. (1983). Vulvar and Vaginal Tumors in the Dog: A Retrospective Study. J Am Vet Med Assoc. 183(6): 690-692.
  • 17-Yuefei Y, Xiaobo W, Yanhong W. (2012). Vaginal Masses in Bitches: Surgical Management and Clinicopathological Report of 5 Cases. J Anim Vet Adv. 11(3): 335-338.
  • 18-Nak D, Mısırlıoğlu D, Nak Y, Alasonyalılar A. (2009). Vaginal Prolapse and Pyometra Associated with a Leiomyoma in an Anatolian Shepherd. Aus Vet Practit. 39(1): 27-30.
  • 19-Sabuncu A, Enginler SÖ, Karaçam E, Günay Z, Demirlek T, Erdoğan Ö, Tek Ç, Gürel A. (2014). Excision of a Vaginal Benign Peripheral Nerve Sheath Tumor (Schwannoma, Neurofibroma) From Abdominal Cavity in an Intact Bitch. Inter J Vet Sci. 3(1): 43-45.
  • 20- Johnston SD. (1989). Vaginal prolapse. In: Current Veterinary Therapy. Kirk RW (ed). 10th ed. pp.1302-1305. Saunders, Philadelphia, USA.
  • 21- Greenberg D, Yates D. (2002). What is Your Diagnosis? J Small Animal Pract. 43(9): 381-406.
  • 22- Klein MK. (2001). Tumours of the Female Reproductive System. In: Small Animal Oncology. Withrow SJ, MacEwen EG (eds). pp: 445-454. Saunders, Philadelphia, USA.
  • 23-Köse AM, Özsoy ŞY, Doğruer G. (2017). Bir Köpekte Vajinal Leyomiyosarkom. Atatürk Üniversitesi Vet Bil Derg. 12(1): 80-83.
  • 24-Sontaş BH, Altun ED, Güvenc K, Arun SS, Ekici H. (2010). Vaginal Neurofibroma in a Hysterectomized Poodle Dog. Reprod Dom Anim. 45: 1130–1133.
  • 25- Feldman EC, Nelson RW. (2004). Vaginal Hyperplasia/Vaginal Prolapse. In: Canine and Feline Endocrinology and Reproduction. Feldman EC, Nelson RW (eds), 3rd ed. pp.906-909. Saunders, Missouri, USA.
  • 26-Baştan I. (2013). Köpeklerde Paraneoplastik Sendrom. Dicle Üniv Vet Fak Derg. 1(4): 19-24.
  • 27-Aydın D, Olgun Erdikmen D, Ülgen S, Demirutku A, Durmuş D. (2011). Kedi ve Köpeklerde Paraneoplastik Sendromlar. Erciyes Üniv Vet Fak Derg. 8(2) 127-137.
  • 28- Bergman JP. (2007). Paraneoplastic Syndromes. In: Withrow & MacEwen’s Small Animal Clinical Oncology. Withrow SJ, Vail DM. (eds.) 4th ed. pp.77-95. Saunders, Missouri, USA.
  • 29- Jurasz P, Alonso-Escolano D, Radomski MW. (2004). Platelet-Cancer Interactions: Mechanisms and Pharmacology of Tumour Cell-Induced Platelet Aggregation. Br J Pharmacol. 143(7): 819-826.
  • 30- Li N. (2016). Platelets in Cancer Metastasis: To Help the "Villain" to Do Evil. Int J Cancer. 138(9): 2078-2087.
  • 31- Jiang S, Liu J, Chen X, Zheng X, Ruan J, Ye A, Zhang S, Zhang L, Kuang Z, Liu R. (2019). Platelet–Lymphocyte Ratio As a Potential Prognostic Factor in Gynecologic Cancers: A Meta-Analysis. Arch Gynecol Obstet. 300: 829–839.
  • 32-Sharma D, Sing G. (2017). Thrombocytosis in Gynecological Cancers. Can Res Ther. 13:193-197.
  • 33- Günay Uçmak Z, Güvenç K. (2019). Malign Meme Tümörlü Dişi Köpeklerde Klinik ve Bazı Hematolojik Parametreler Arasındaki İlişkinin Değerlendirilmesi. Turkiye Klinikleri J Vet Sci. 10(2): 45-52.
  • 34-Carlin GL, Bodner K, Kimberger O, Haslinger P, Schneeberger C, Horvat R, Kölbl H, Umek W, Bodner-Adler B. (2020). The Role of Transforming Growth Factor-ß (TGF-ß1) in Postmenopausal Women with Pelvic Organ Prolapse: An Immunohistochemical Study. Eur J Obstet Gynecol Reprod Biol. 7: 100111.
  • 35- Anitua E, Sanchez M, Orive G, Andia I. (2007). The Potential Impact of The Preparation Rich in Growth Factors (PRGF) in Different Medical Fields. Biomaterials. 28: 4551–4560.
  • 36-Johnston SD, Kustritz MVR, Olson PNS. (2001). Canine and Feline Theriogenology. Saunders Company, London, United Kingdom.
  • 37-Küplülü S, Vural MR, Kilicoglu C, Izgur H, Colak A. (1992). The Treatment of Vaginal Hyperplasia Cases with Medroxyprogesterone Acetate in The Bitch. Ankara Üniv Vet Fak Derg. 39(1-2): 316-324.
  • 38-Rollon E, Millan Y, De Las Mulas JM. (2008). Effects of Aglepristone, A Progesterone Receptor Antagonist in a Dog with a Vaginal Fibroma. J Small Anim Pract. 49: 41-43.

Dişi Köpeklerde Vajinal Hiperplazi ve Vajinal Tümörler ile İlişkili Hematolojik Parametrelerde Değişiklikler

Yıl 2021, Cilt: 14 Sayı: 1, 62 - 66, 30.06.2021

Zeynep Günay Uçmak Özge Erdoğan Bamaç

https://doi.org/10.47027/duvetfd.892302

Öz

Çalışmanın amacı, vajinal hiperplazili (VH), vajinal tümörlü (VT) ve sağlıklı genital kanala sahip (H) köpeklerde klinik, hematolojik ve histopatolojik değişimlerin incelenmesidir. Çalışma grupları; grup VH (n=9), grup VT (n=10), grup H’dan (n=13) oluştu. Tüm dişi köpekler klinik (vajinal sitoloji, vajinoskopi), hematolojik ve histopatolojik olarak değerlendirildi. Grup H'deki dişiler anöstrustaydı, grup VH ve grup VT'deki dişiler ise östrustaydı. Grup VT'de azalmış RBC, HGB, HCT seviyeleri ve WBC'de artış tespit edildi. Grup VH'deki HGB düzeyi ortalamaları grup H'den daha düşük olma eğilimindeyken (P=0,05), grup VH'deki HCT düzeyi ortalamaları grup H’ye göre önemli ölçüde azdı. Ortalama RBC, HGB, HCT ve WBC değerleri, vajinal kıvrım sarkması derecesi ile önemli ölçüde ilişkili değilken (P>0,05), tip 2 VH'li dişi köpeklerde PLT ve PCT ortalamaları, tip 3 VH'den daha yüksek olma eğilimindeydi (P=0,07). Grup VH'deki dişilerde histopatolojik incelemede skuamöz epitelde kalınlaşma ve lamina propriada belirgin ödem saptandı. Grup VT’de yer alan tümörlerin histolojik teşhisi; fibrom (n=4), leiomiyom (n=3), periferik sinir kılıfı tümörü (n=1), bulaşıcı venereal tümör (n=1) ve leiomiyosarkomdu (n=1). Sonuç olarak, vajinal kitlesi olan dişilerde hematolojik değişiklikler değerlendirildi ve VH ve VT'li köpeklerde hafif anemi ve lökositoz belirlendi. Bildiğimiz kadarıyla bu, VH'li dişi köpeklerde hafif anemiyi ve vajinal kıvrım sarkmasının derecesi ile ilgili PLT ve PCT değerlerindeki farklılıkları saptayan ilk çalışmadır.

Anahtar Kelimeler

Hematoloji köpek vajinal kitle

Kaynakça

  • 1-Manothaiudom K, Johnston SD. (1991). Clinical Approach to Vaginal/ Vestibular Masses in the Bitch. Vet Clin North Am Small Anim Pract. 21(3): 509-521.
  • 2-Sontaş BH, Ekici H, Romagnoli S. (2010). Canine Vaginal Fold Prolapse: A Comprehensive Literature Review. EJCAP. 20(2): 127-135.
  • 3-Nak D, Nak Y, Yılmazbaş G. (2008). First Report of Vaginal Prolapse in an Ovariohysterectomised Bitch - A Case Report. Bull Vet Inst Pulawy. 52: 397-398.
  • 4-Alan M, Çetin Y, Sendag S, Eski F. (2007). True Vaginal Prolapse in a Bitch. Anim Reprod Sci. 100: 411–414.
  • 5-Canoğlu E. (2013). Köpeklerde Vaginal Hiperplazi: Tanı ve Tedavi Seçenekleri. Erciyes Univ Vet Fak Derg. 10(3): 177-183.
  • 6-Babu A, Becha BB, Jayakumar C, Simon S, Raj IV, Kurien MO. (2020). Occurrence of Vaginal Hyperplasia Among Intact Dogs. J. Vet. Anim. Sci. 51(2): 142-145.
  • 7-Gouletsou PG, Galatos AD, Apostolidis K, Sideri AI. (2009). Vaginal Fold Prolapse During the Last Third of Pregnancy, Followed by Normal Parturition, in a Bitch. Anim Reprod Sci. 112: 371–376.
  • 8-Kurt S, Salar S, Baştan A. (2019). Effect of Vaginal Fold Prolapse Occurrence in a Pregnant Bitch on Parturition Process. Vet Hekim Der Derg. 90(1): 50-54.
  • 9-Şafak T, Yılmaz Ö, Ercan K, Yüksel BF, Öcal H. (2021). A Case of Vaginal Hyperplasia Occurred the Last Trimester of Pregnancy in a Kangal Bitch. Ankara Univ Vet Fak Derg. DOI: 10.33988/auvfd.764656
  • 10- Schutte AP. (1967). Vaginal Prolapse in the Bitch. J South Afr Vet Med Assoc. 38: 197-203.
  • 11- Soderberg SF. (1986). Vaginal Disorders. Vet Clin North Am Small Anim Pract. 16: 543-559.
  • 12- Post K, Haaften BV, Okkens AC. (1991). Vaginal Hyperplasia in the Bitch: Literature Review and Commentary. Can Vet J. 32(1): 35-37.
  • 13-Troger CP. (1970). Vaginal Prolapse in the Bitch. Mod Vet Prac. 51: 38-41.
  • 14-McEntee MC. (2002). Reproductive Oncology. Clin Tech Small Anim Pract. 17(3): 133–149.
  • 15-Kydd DM, Burnie AG. (1986). Vaginal Neoplasia in the Bitch: a Review of Forty Clinical Cases. J. Small Anim Pract. 27: 255-263.
  • 16-Thacher C, Bradley RL. (1983). Vulvar and Vaginal Tumors in the Dog: A Retrospective Study. J Am Vet Med Assoc. 183(6): 690-692.
  • 17-Yuefei Y, Xiaobo W, Yanhong W. (2012). Vaginal Masses in Bitches: Surgical Management and Clinicopathological Report of 5 Cases. J Anim Vet Adv. 11(3): 335-338.
  • 18-Nak D, Mısırlıoğlu D, Nak Y, Alasonyalılar A. (2009). Vaginal Prolapse and Pyometra Associated with a Leiomyoma in an Anatolian Shepherd. Aus Vet Practit. 39(1): 27-30.
  • 19-Sabuncu A, Enginler SÖ, Karaçam E, Günay Z, Demirlek T, Erdoğan Ö, Tek Ç, Gürel A. (2014). Excision of a Vaginal Benign Peripheral Nerve Sheath Tumor (Schwannoma, Neurofibroma) From Abdominal Cavity in an Intact Bitch. Inter J Vet Sci. 3(1): 43-45.
  • 20- Johnston SD. (1989). Vaginal prolapse. In: Current Veterinary Therapy. Kirk RW (ed). 10th ed. pp.1302-1305. Saunders, Philadelphia, USA.
  • 21- Greenberg D, Yates D. (2002). What is Your Diagnosis? J Small Animal Pract. 43(9): 381-406.
  • 22- Klein MK. (2001). Tumours of the Female Reproductive System. In: Small Animal Oncology. Withrow SJ, MacEwen EG (eds). pp: 445-454. Saunders, Philadelphia, USA.
  • 23-Köse AM, Özsoy ŞY, Doğruer G. (2017). Bir Köpekte Vajinal Leyomiyosarkom. Atatürk Üniversitesi Vet Bil Derg. 12(1): 80-83.
  • 24-Sontaş BH, Altun ED, Güvenc K, Arun SS, Ekici H. (2010). Vaginal Neurofibroma in a Hysterectomized Poodle Dog. Reprod Dom Anim. 45: 1130–1133.
  • 25- Feldman EC, Nelson RW. (2004). Vaginal Hyperplasia/Vaginal Prolapse. In: Canine and Feline Endocrinology and Reproduction. Feldman EC, Nelson RW (eds), 3rd ed. pp.906-909. Saunders, Missouri, USA.
  • 26-Baştan I. (2013). Köpeklerde Paraneoplastik Sendrom. Dicle Üniv Vet Fak Derg. 1(4): 19-24.
  • 27-Aydın D, Olgun Erdikmen D, Ülgen S, Demirutku A, Durmuş D. (2011). Kedi ve Köpeklerde Paraneoplastik Sendromlar. Erciyes Üniv Vet Fak Derg. 8(2) 127-137.
  • 28- Bergman JP. (2007). Paraneoplastic Syndromes. In: Withrow & MacEwen’s Small Animal Clinical Oncology. Withrow SJ, Vail DM. (eds.) 4th ed. pp.77-95. Saunders, Missouri, USA.
  • 29- Jurasz P, Alonso-Escolano D, Radomski MW. (2004). Platelet-Cancer Interactions: Mechanisms and Pharmacology of Tumour Cell-Induced Platelet Aggregation. Br J Pharmacol. 143(7): 819-826.
  • 30- Li N. (2016). Platelets in Cancer Metastasis: To Help the "Villain" to Do Evil. Int J Cancer. 138(9): 2078-2087.
  • 31- Jiang S, Liu J, Chen X, Zheng X, Ruan J, Ye A, Zhang S, Zhang L, Kuang Z, Liu R. (2019). Platelet–Lymphocyte Ratio As a Potential Prognostic Factor in Gynecologic Cancers: A Meta-Analysis. Arch Gynecol Obstet. 300: 829–839.
  • 32-Sharma D, Sing G. (2017). Thrombocytosis in Gynecological Cancers. Can Res Ther. 13:193-197.
  • 33- Günay Uçmak Z, Güvenç K. (2019). Malign Meme Tümörlü Dişi Köpeklerde Klinik ve Bazı Hematolojik Parametreler Arasındaki İlişkinin Değerlendirilmesi. Turkiye Klinikleri J Vet Sci. 10(2): 45-52.
  • 34-Carlin GL, Bodner K, Kimberger O, Haslinger P, Schneeberger C, Horvat R, Kölbl H, Umek W, Bodner-Adler B. (2020). The Role of Transforming Growth Factor-ß (TGF-ß1) in Postmenopausal Women with Pelvic Organ Prolapse: An Immunohistochemical Study. Eur J Obstet Gynecol Reprod Biol. 7: 100111.
  • 35- Anitua E, Sanchez M, Orive G, Andia I. (2007). The Potential Impact of The Preparation Rich in Growth Factors (PRGF) in Different Medical Fields. Biomaterials. 28: 4551–4560.
  • 36-Johnston SD, Kustritz MVR, Olson PNS. (2001). Canine and Feline Theriogenology. Saunders Company, London, United Kingdom.
  • 37-Küplülü S, Vural MR, Kilicoglu C, Izgur H, Colak A. (1992). The Treatment of Vaginal Hyperplasia Cases with Medroxyprogesterone Acetate in The Bitch. Ankara Üniv Vet Fak Derg. 39(1-2): 316-324.
  • 38-Rollon E, Millan Y, De Las Mulas JM. (2008). Effects of Aglepristone, A Progesterone Receptor Antagonist in a Dog with a Vaginal Fibroma. J Small Anim Pract. 49: 41-43.
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm Araştıma
Yazarlar

Zeynep Günay Uçmak Bu kişi benim 0000-0003-2530-1291

Özge Erdoğan Bamaç 0000-0002-0352-4841

Yayımlanma Tarihi 30 Haziran 2021
Kabul Tarihi 9 Mayıs 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 14 Sayı: 1

Kaynak Göster

APA Günay Uçmak, Z., & Erdoğan Bamaç, Ö. (2021). Changes in Hematological Parameters Associated with Vaginal Hyperplasia and Vaginal Tumors in Bitches. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 14(1), 62-66. https://doi.org/10.47027/duvetfd.892302
AMA Günay Uçmak Z, Erdoğan Bamaç Ö. Changes in Hematological Parameters Associated with Vaginal Hyperplasia and Vaginal Tumors in Bitches. Dicle Üniv Vet Fak Derg. Haziran 2021;14(1):62-66. doi:10.47027/duvetfd.892302
Chicago Günay Uçmak, Zeynep, ve Özge Erdoğan Bamaç. “Changes in Hematological Parameters Associated With Vaginal Hyperplasia and Vaginal Tumors in Bitches”. Dicle Üniversitesi Veteriner Fakültesi Dergisi 14, sy. 1 (Haziran 2021): 62-66. https://doi.org/10.47027/duvetfd.892302.
EndNote Günay Uçmak Z, Erdoğan Bamaç Ö (01 Haziran 2021) Changes in Hematological Parameters Associated with Vaginal Hyperplasia and Vaginal Tumors in Bitches. Dicle Üniversitesi Veteriner Fakültesi Dergisi 14 1 62–66.
IEEE Z. Günay Uçmak ve Ö. Erdoğan Bamaç, “Changes in Hematological Parameters Associated with Vaginal Hyperplasia and Vaginal Tumors in Bitches”, Dicle Üniv Vet Fak Derg, c. 14, sy. 1, ss. 62–66, 2021, doi: 10.47027/duvetfd.892302.
ISNAD Günay Uçmak, Zeynep - Erdoğan Bamaç, Özge. “Changes in Hematological Parameters Associated With Vaginal Hyperplasia and Vaginal Tumors in Bitches”. Dicle Üniversitesi Veteriner Fakültesi Dergisi 14/1 (Haziran 2021), 62-66. https://doi.org/10.47027/duvetfd.892302.
JAMA Günay Uçmak Z, Erdoğan Bamaç Ö. Changes in Hematological Parameters Associated with Vaginal Hyperplasia and Vaginal Tumors in Bitches. Dicle Üniv Vet Fak Derg. 2021;14:62–66.
MLA Günay Uçmak, Zeynep ve Özge Erdoğan Bamaç. “Changes in Hematological Parameters Associated With Vaginal Hyperplasia and Vaginal Tumors in Bitches”. Dicle Üniversitesi Veteriner Fakültesi Dergisi, c. 14, sy. 1, 2021, ss. 62-66, doi:10.47027/duvetfd.892302.
Vancouver Günay Uçmak Z, Erdoğan Bamaç Ö. Changes in Hematological Parameters Associated with Vaginal Hyperplasia and Vaginal Tumors in Bitches. Dicle Üniv Vet Fak Derg. 2021;14(1):62-6.
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