The Benefits of Sacubitril-Valsartan in Low Ejection Fraction Heart Failure

Year 2022, , 337 - 336, 30.12.2022

Lütfü Aşkın , Okan Tanrıverdi

https://doi.org/10.47493/abantmedj.1182158

Cited By: 3

Abstract

Heart failure (HF) is the cause of impaired exercise capacity due to insufficient peripheral blood flow. The development of natriuretic peptide (NP) through inhibition of the neprilysin enzyme is the therapeutic target in HF. Sacubitril/valsartan reduces mortality and hospitalization and rehospitalization rates for HF compared with enalapril. In HF patients, sacubitril or valsartan may provide significant benefit.

Keywords

Heart Failure, Natriuretic Peptide, Sacubitril/Valsartan

Düşük Ejeksiyon Fraksiyonu ile Kalp Yetmezliğinde Sakubitril-Valsartanın Faydaları

Abstract

Kalp yetmezliği (KY), perifere yetersiz kan akışı nedeniyle egzersiz kapasitesinin bozulmasının nedenidir. Neprilisin enziminin inhibisyonu yoluyla natriüretik peptit (NP) geliştirmesi, KY' deki terapötik hedeftir. Sakubitril/valsartan, enalapril ile karşılaştırıldığında KY için mortalite ve hastaneye yatış ve yeniden hastaneye yatış oranlarını azaltır. Sakubitril/valsartan KY hastalarında önemli fayda sağlayabilir.

Keywords

Kalp Yetmezliği, Natriüretik Peptit, Sakubitril/Valsartan, Heart Failure, Natriuretic Peptide, Sacubitril/Valsartan

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