Ultrasonographic Evaluation of Common Carotid and Femoral Artery IMT and Compliance After Atorvastatin Treatment in Premenopausal Dyslipidemic Female Patients

Abstract

INTRODUCTION: In this study we aimed to evaluate the effect of atorvastatin treatment on common carotid artery CCA and femoral artery FA intima media thickness IMT and arterial compliance by using ultrasonography US in premenopausal females with dyslipidemia. METHODS: The current study consisted of 40 premenopausal women with a diagnosis of dyslipidemia. The participants received 80 mg/day atorvastatin for 60 days, baseline and posttreatment measurements were performed on the first day of menstruation to avoid the possible effect of the menstrual cycle. Ultrasonographic measurements were non-invasively taken using a high resolution US system. Arterial compliance was evaluated using several indicators, such as cross-sectional compliance CSC , cross-sectional distensibility CSD , diastolic wall stress DWS , and elastic modulus EM . Data obtained at baseline and in the second post-treatment month were compared via a Wilcoxon test, p values of

Keywords

• Arterial compliance, Atorvastatin, dyslipidemia, intima-media thickness, stiffness

Premenopozal Dislipidemik Kadın Hastalarda Atorvastatin Tedavisi Sonrası Ana Karotid ve Femoral Arter IMK ve Kompliyansının Ultrasonografik Olarak Değerlendirilmesi

Abstract

GİRİŞ ve AMAÇ: Bu çalışmada dislipidemik premenopozal kadın hasta grubunda ultrasonografi US ile atorvastatin tedavisinin ana karotid arter ve femoral arter intima media kalınlığı IMK ile arteriyel kompliyans üzerine etkisini değerlendirmeyi amaçladık.YÖNTEM ve GEREÇLER: Bu çalışmada dislipidemi tanısı bulunan 40 premenopozal kadın yer aldı. Katılımcılar 60 gün boyunca 80 mg / gün atorvastatin aldı; bazal ve tedavi sonrası ölçümleri adet döngüsünün olası etkisini önlemek için adetin ilk günü yapıldı. Ölçümler non-invazif olarak yüksek çözünürlüklü bir ultrasonografi cihazı ile yapıldı. Arteriyel kompliyans kesitsel kompliyans, kesitsel esneklik, diyastolik duvar basıncı ve elastik modül gibi çeşitli göstergeler kullanılarak değerlendirildi. Başlangıçta ve iki aylık tedavi sonrası elde edilen veriler Wilcoxon testi ile karşılaştırıldı, p

Keywords

• Arteriyel kompliyans, Atorvastatin, dislipidemi, intima-media kalınlığı, sertlik

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