Association between red cell distribution width RDW and hs-CRP in patients with Cardiac Syndrome X

Abstract

OBJECTIVE: Cardiac Syndrome X CSX is defined as typical chest pain, objective signs of ischemia and normal coronary arteries. The association between CSX and inflammation is well known. Red cell distribution width RDW , an index of erythrocyte size, is recently found to be associated with inflammation. We investigated the association between RDW and high sensitive C reactive protein hs-CRP in patients with CSX.METHODS: Total 104 patients were included in the study. Those with evidence of ischemia total of 70 underwent coronary angiography. Patients with a normal coronary angiogram were grouped as the CSX group n=35 and those with significant coronary disease were grouped as the coronary artery disease CAD group n=35 . A total of 34 patients were taken as the control group. RDW and hs-CRP levels were measuredRESULTS: RDW was increased in the CSX group when compared to the Control group 13.9 ± 1.2 vs 12.9 ±0.7, p < 0.001 . However, there was no difference between the CSX and CAD groups 13.9 ± 1.2 vs. 14,1 ± 1,1, p: 0. 63 . Both groups had higher hs-CRP levels than the Control group. RDW is correlated with hs-CRP r=0.24, p: 0.014 .CONCLUSION: RDW, a novel inflammatory marker, is elevated in CSX and may be promising biomarker in reflecting the inflammatory status in CSX patients.

Keywords

• Cardiac syndrome X,RDW,hs-CRP,inflammation

Kardiyak Sendrom X'de Eritrosit dağılım genişliği RDW ile hs-CRP seviyelerinin incelenmesi

Abstract

AMAÇ: Kardiyak Sendrom X KSX , angina pektoris ve objektif iskemi bulgularına rağmen normal koroner arterlerin saptandığı bir tablodur. KSX’ in patogenezinde inflamasyonun rol oynadığı bulunmuştur. Eritrosit dağılım genişliği RDW , dolaşımdaki eritrositlerin büyüklüğünü gösteren bir indeks olmasının yanında, son çalışmalarda inflamasyonu gösteren bir parametre olarak değerlendirilmeye başlanmıştır. Biz bu çalışmada KSX olan hastalarda inflamasyon ile RDW arasındaki ilişkiyi araştırdıkYÖNTEMLER: Bu çalışmaya iskemik bulguların saptandığı koroner anjiyografisi normal olan 35 KSX hastası KSX grubu , ciddi koroner arter hastalığı bulunan 35 hasta KAH grubu ve 34 kontrol hastası alındı. Her üç gruptan RDW ve hs-CRP çalışıldıBULGULAR: KSX grubunda RDW değerleri kontrol grubuna göre artmış bulundu 13.9 ± 1.2 vs 12.9 ±0.7, p < 0.001 . Ancak KSX grubu ile KAH grubu arasında fark bulunmadı 13.9 ± 1.2 vs. 14,1 ± 1,1, p: 0. 63 . Aynı şekilde KSX ile KAH grubu arasında hs-CRP değerleri arasında fark yoktu 1.03 ± 0.5 vs. 1.05 ± 0.5, p: 0.92 . Kontrol grubunda hs-CRP düzeyi KSX ve KAH grubuna göre anlamlı bir şekilde düşük bulundu. RDW ile hs-CRP arasında pozitif korelasyon olduğu bulundu r=0.24, p: 0.014 . SONUÇ: RDW, klinikte uzun süredir bilinen ancak inflamatuvar marker olarak yeni kullanılan bir parametre olup KSX olan hastalarda yükselmektedir.

Keywords

• Kardiyak sendrom X,RDW,hs-CRP,inflamasyon

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