Lipid panel with Non-HDL cholesterol and total cholesterol/HDL cholesterol ratio

Yıl 2015, Cilt: 4 Sayı: 1, 28 - 32, 01.01.2015

Hatice Yüksel İbrahim Kaplan Tahsin Celepkolu Gülten Toprak Nurefşan Aydeniz Emel Etik Leyla Çolpan

https://doi.org/10.5505/abantmedj.2015.80764

Öz

OBJECTIVE: In our study, the importance of the computational tests such as non-HDL cholesterol and Total cholesterol to HDL ratio for evaluating blood lipid levels were investigated.METHODS: The measured and calculated lipid parameters of 683 patients whose test inputs were done from Family Medicine Clinic were evaluated. The number of the patients were determined who had high Non-HDL cholesterol and total cholesterol / HDL cholesterol however the the routine lipid parameters were in the acceptable range.RESULTS: According to our results, 45 6.6% patients had high non-HDL cholesterol values and 127 %18,6 patients had high TC / HDL-cholesterol levels. Also, there were 11 1.6% patients with high non-HDL-cholesterol levels, and 39 %5,7 patients with high TC / HDL cholesterol ratio, while all routine lipid parameters were in acceptable limits. CONCLUSION: The addition of Non-HDL cholesterol and TC / HDL-cholesterol ratio to routine laboratory results would be beneficial because it can create an alert to clinicians in terms of lipid disorders.

Anahtar Kelimeler

Non-HDL cholesterol, total cholesterol / HDL cholesterol ratio, lipid parameters

Lipid panelinde Non-HDL kolesterol ve Total kolesterol / HDL kolesterol oranı

Öz

AMAÇ: Çalışmamızda, kan lipid düzeylerinin değerlendirilmesinde, hesaplamalı test olan Non-HDL kolesterol ve Total kolesterol/HDL kolesterol değerlendirilmesinin önemi incelenmiştir.YÖNTEMLER: Aile hekimliği polikliniğinden yapılan laboratuvar istemlerinden 683 hastanın hem ölçülen hem de hesaplanan lipid parametreleri değerlendirildi. Rutinde çalışılan lipid parametrelerine göre kabul edilebilir aralıkta olup da Non-HDL kolesterol ve Total kolesterol/HDL değerine göre hedef değerlerin üstünde kalan hasta sayıları belirlendi. BULGULAR: Çalışmamızın sonuçlarına göre, 45 %6,6 hasta yüksek Non-HDL kolesterol değerlerine ve 127 %18,6 hasta yüksek TK/HDL-K oranına sahiptir. Tüm rutin lipid parametreleri kabul edilebilir sınırlarda iken, Non-HDL kolesterol değerleri yüksek olan 11 %1,6 hasta ve ve TK/HDL kolesterol oranı yüksek olan 39 %5,7 hasta saptandı. saptandı.SONUÇ: Non-HDL kolesterol değerinin ve TK/HDL-K oranının rutin lipit sonuçlarına eklenmesi, klinisyenlere lipit bozukluğu açısından uyarı oluşturabileceğinden faydalı olacaktır.

Anahtar Kelimeler

Non-HDL kolesterol, TK/HDL kolesterol oranı, lipid parametreleri

Kaynakça

• 1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al. Heart Disease and Stroke Statistics—2013 Update A Report From the American Heart Association. Circulation 2013;127: e6–e245.
• 2. Öztürk S, Öztürk S. Approach of Dislipidemia; As a cardiovascular risk factor. Abant Med J 2012; 1: 89-93
• 3. The Emerging Risk Factors Collaboration*. LIpidrelated markers and cardiovascular disease prediction. JAMA 2012; 307: 2499–506.
• 4. ATP III Guidelines At-A-Glance Quick Desk Reference. National Cholesterol Education Program NIH Publication No. 01-3305 May 2001.
• 5. Hastalıklardan Korunma Kılavuzu (Versiyon 2012). Archives of the Turkish Society of Cardiology 2012; volume : 40.
• 6. Tanrıverdi H, Celepkolu T, Aslanhan H. Diabetes mellitus and primary healthcare. Journal of Clinical and Experimental Investigations 2013; 4: 562-567.
• 7. Superko HR, King S. Lipid Management to Reduce Cardiovascular Risk: A New Strategy Is Required. Circulation 2008;117: 560–8.
• 8. Lu W, Resnick HE, Jablonski KA, Jones KL, Jain AK, Howard WJ, et al. Non-HDL cholesterol as a predictor of cardiovascular disease in type 2 diabetes: the strong heart study. Diabetes Care 2003; 26: 16–23.
• 9. Anderson TJ, Grégoire J, Hegele RA, Couture P, Mancini GBJ, McPherson R, et al. 2012 Update of the Canadian Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult. Can J Cardiol 2013 ; 29: 151–67.
• 10. Gotto AM. Triglyceride The Forgotten Risk Factor. Circulation 1998; 97: 1027–8.
• 11. Akpinar O, Bozkurt A, Acarturk E, Seydaoglu G. A new index (CHOLINDEX) in detecting coronary artery disease risk. Anatol J Cardiol 2013; 13: 315-9.
• 12. Manninen V, Tenkanen L, Koskinen P, Huttunen JK, Mänttäri M, Heinonen OP, et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation 1992; 85: 37–45.
• 13. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499–502.
• 14. Ram N, Ahmed B, Hashmi F, Jabbar A. Importance of measuring non-HDL cholesterol in type 2 diabetes patients. J Pak Med Assoc 2014; 64: 124–8.
• 15. Arsenault BJ, Rana JS, Stroes ESG, Després J-P, Shah PK, Kastelein JJP, et al. Beyond LowDensity Lipoprotein Cholesterol: Respective Contributions of Non–High-Density Lipoprotein Cholesterol Levels, Triglycerides, and the Total Cholesterol/High-Density Lipoprotein Cholesterol Ratio to Coronary Heart Disease Risk in Apparently Healthy Men and Women. J Am Coll Cardiol 2009; 55: 35–41.