The relationship of Cag-A in patients with HP positive alopecia areata and vitiligo

Year 2015, Volume: 4 Issue: 4, 366 - 370, 01.11.2015

Gamze Erfan Mustafa Oran Rafet Mete Hayati Güneş Mehmet Emin Yanık Hulya Albayrak Mustafa Kaan Taşolar Murat Aydın Birol Topçu Mustafa Kulaç

https://doi.org/10.5505/abantmedj.2015.77598

Abstract

INTRODUCTION: Even though some dermatological diseases have been related to Helicobacter pylori HP , in alopecia areata there are conflicting data. The reason of this conflict might be Cag-A cytotoxin-associated gene A which is one of the factors responsible from virulance of HP. According to the search of medical literature in vitiligo there is only one study which reports possible role of HP and Cag-A.METHODS: HP stool antigen and Cag-A seroprevalence in serum with ELISA investigated in 60 healthy subjects, 60 AA and 52 vitiligo patients without history, symptom, diagnosis and treatment of dyspepsia, autoimmun disorders and other infections. The severity of diseases were assessed by severity of alopecia tool/SALT and rule of nine and relationship between HP, Cag-A positivity and severity of diseases were investigated.RESULTS: Fourthy-three %71.7 of AA, 26 %50 of vitiligo patients were HP + . Also Cag-A positivity was in 26 %60,4 of AA, 17 %65,3 of vitiligo patients. In comparison of healthy subjects and AA patients HP and Cag-A positivity were significantly higher in AA patients p

Keywords

Alopecia areata, autoimmunity, Cag-A protein, helicobacter pylori, virulance, vitiligo

Helicobacter Pylori pozitif Alopesi areata ve Vitiligo hastalarında Cag-A ilişkisi

Abstract

GİRİŞ ve AMAÇ: Helicobacter Pylori HP ile bazı dermatolojik hastalıklar arasında ilişki kurulurken, alopesi areata AA ve HP arasında çelişkili veriler mevcuttur. Bu çelişkili sonuçların nedeni, HP’nin virulansından sorumlu faktörlerden biri olan Cag-A sitotoksin ilişkili gen ürünü A olabilir. Vitiligoda ise HP’nin muhtemel rolü hakkında tıbbı literatürde çok az sayıda çalışma bulunmaktadır. Literatürde tespit edilebildiği kadarıyla Cag-A + suşlarının rolünün saptandığı sadece bir çalışma bulunmaktadır. YÖNTEM ve GEREÇLER: Altmış AA ve 52 vitiligo tanısı almış, dispepsi, eşlik eden otoimmün hastalıklar ve diğer enfeksiyonlar açısından hikâye, belirti, tanı ve tedavileri olmayan hastalar ve 60 sağlıklı bireyde HP stool antijeni ve serumlarında Cag-A seroprevelansı ELİSA kullanılarak incelendi. Hastalık şiddetleri AA grubunda alopesi şiddet ölçeği SALT skoru ve vitiligo grubunda ise “dokuzlar kuralı” ile ölçüldü ve HP, Cag-A pozitifliği ile ilişkisi karşılaştırıldı.BULGULAR: AA grubunda 43 %71,7 , vitiligo grubunda 26 %50 hastada HP + ’liği saptandı. Bu hastalardan AA hastalarında Cag-A + ’liği 26 %60,4 , vitiligo hastalarında 17 %65,3 kişide saptandı. AA hastaları ile kontrol grubu karşılaştırıldığında, HP + ’liği ve Cag-A + ’liği AA hastalarında belirgin olarak yüksek sayıda saptanırken p

Keywords

Alopesi areata, Cag-A, helicobacter pylori, otoimmunite, virulans, vitiligo

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