Adequacy of nucleer matrix protein 22 to determine recurrences in patients with bladder cancer

Yıl 2012, Cilt: 1 Sayı: 1, 18 - 22, 01.01.2012

Emin Savaş Kılavuz Mehmet Tosun Ahmet Rıza Uras

https://doi.org/10.5505/abantmedj.2012.68077

Öz

Aim: To investigate the ability of nuclear matrix protein 22 NMP22 to determine recurrence in patients underwent transurethral resection of bladder tumor TURM Material and methods: NMP22 measured in urine of 148 patients applied TUR-M. According to cystoscopy and pathology results, the sensitivity, specifity, positive and negative predictive value of NMP22 test was determined in patients suspected bladder cancer recurrancy. Furthermore, the effects of urine erythrocyte and leukocyte levels on NMP22 test were investigated. Results: We calculated the sensitivity %36.8, specifity %88, positive predictive value %32 and negative predictive value %90. There was statically significant relation between urine leukocyte amount and NMP22 r=0,237, p

Anahtar Kelimeler

NMP22, bladder cancer, TUR-M, cystoscopy

Nükleer matriks protein 22'nin mesane kanserli hastalarda rekürrensleri belirleyebilme yeterliliği

Öz

Amaç: Transüteral mesane tümörü rezeksiyonu TUR-M uygulanan hastalarda Nükleer Matriks Protein 22 NMP22 ’nin rekürrens belirleyebilme yeteneğinin araştırılması. Gereç ve Yöntem: TUR-M tedavisi uygulanmış 148 hastanın idrarında NMP22 ölçümü yapıldı. Sistoskopi sonuçlarına göre ve mesane kanseri rekürrensi şüphelenilip patolojiye gönderilen vakaların sonuçlarına göre NMP22 testinin duyarlılığı, özgüllüğü, pozitif ve negatif kestirim değeri belirlendi. Ayrıca idrardaki eritrosit ve lökosit düzeylerinin NMP22 testine etkisi araştırıldı. Bulgular: Duyarlılığı %36,8, özgüllüğü %88, negatif kestirim değeri %90, pozitif kestirim değeri %32 olarak hesapladık. İdrarda lökosit miktarı ile NMP22 değerleri arasında istatistikî bakımdan ilişki tespit ettik r=0,237, p

Anahtar Kelimeler

NMP22, mesane kanseri, TUR-M, sistoskopi

Kaynakça

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